KR20080013971A - 에르골린 유도체 및 케모카인 수용체 리간드로서 그의 용도 - Google Patents
에르골린 유도체 및 케모카인 수용체 리간드로서 그의 용도 Download PDFInfo
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- KR20080013971A KR20080013971A KR1020077027902A KR20077027902A KR20080013971A KR 20080013971 A KR20080013971 A KR 20080013971A KR 1020077027902 A KR1020077027902 A KR 1020077027902A KR 20077027902 A KR20077027902 A KR 20077027902A KR 20080013971 A KR20080013971 A KR 20080013971A
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- 239000003446 ligand Substances 0.000 title claims abstract description 16
- 102000009410 Chemokine receptor Human genes 0.000 title claims abstract description 8
- 108050000299 Chemokine receptor Proteins 0.000 title claims abstract description 8
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- -1 heteroaryl N-oxides Chemical class 0.000 claims abstract description 27
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
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- 125000006552 (C3-C8) cycloalkyl group Chemical class 0.000 claims abstract description 4
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- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
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- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
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- 239000008346 aqueous phase Substances 0.000 description 4
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- 239000003018 immunosuppressive agent Substances 0.000 description 4
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
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- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
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- Biomedical Technology (AREA)
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- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
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- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0511060.6A GB0511060D0 (en) | 2005-05-31 | 2005-05-31 | Organic compounds |
| GB0511060.6 | 2005-05-31 |
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| Publication Number | Publication Date |
|---|---|
| KR20080013971A true KR20080013971A (ko) | 2008-02-13 |
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| EP (1) | EP1893611A1 (https=) |
| JP (1) | JP5121703B2 (https=) |
| KR (1) | KR20080013971A (https=) |
| CN (1) | CN101184754B (https=) |
| AU (1) | AU2006254395B2 (https=) |
| BR (1) | BRPI0611489A2 (https=) |
| CA (1) | CA2608702C (https=) |
| GB (1) | GB0511060D0 (https=) |
| MX (1) | MX2007015084A (https=) |
| RU (1) | RU2416613C2 (https=) |
| WO (1) | WO2006128658A1 (https=) |
Families Citing this family (16)
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| IN2012DN04858A (https=) * | 2009-12-23 | 2015-09-25 | Map Pharmaceuticals Inc | |
| US9095591B2 (en) | 2010-06-28 | 2015-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Pharmaceutical composition for use in the treatment of glaucoma |
| KR20140042868A (ko) | 2011-06-23 | 2014-04-07 | 맵 파마슈티컬스, 인코포레이티드 | 신규한 플루오로에르골린 유사체 |
| SG10201509139QA (en) | 2011-12-19 | 2015-12-30 | Map Pharmaceuticals Inc | Novel iso-ergoline derivatives |
| CA2859175A1 (en) | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
| RU2014153672A (ru) * | 2012-06-22 | 2016-08-10 | Мап Фармасьютикалс, Инк. | Новые каберголиновые производные |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| MX2017009405A (es) | 2015-01-20 | 2018-01-18 | Xoc Pharmaceuticals Inc | Compuestos de tipo ergolina y usos de estos. |
| EP3247357A4 (en) | 2015-01-20 | 2018-07-11 | Xoc Pharmaceuticals, Inc | Isoergoline compounds and uses thereof |
| WO2018223065A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| EP4329759A4 (en) | 2021-04-30 | 2025-07-16 | Mind Medicine Inc | CRYSTALLINE FORMS OF LSD SALTS |
| US12611399B2 (en) | 2021-05-04 | 2026-04-28 | Definium Therapeutics US, Inc. | Movement disorders |
| JP7846211B2 (ja) | 2021-08-19 | 2026-04-14 | デフィニウム セラピューティクス ユーエス， インコーポレイテッド | 治療適用のためのｄ－リゼルグ酸ジエチルアミドの即時放出製剤 |
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| WO2000042071A2 (en) | 1999-01-12 | 2000-07-20 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| EP2070921A1 (en) | 2000-11-07 | 2009-06-17 | Novartis Ag | Indolylmaleimide derivatives as protein kinase c inhibitors |
| TW200918046A (en) | 2002-04-03 | 2009-05-01 | Novartis Ag | Indolylmaleimide derivatives |
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2005
- 2005-05-31 GB GBGB0511060.6A patent/GB0511060D0/en not_active Ceased
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2006
- 2006-05-29 MX MX2007015084A patent/MX2007015084A/es active IP Right Grant
- 2006-05-29 KR KR1020077027902A patent/KR20080013971A/ko not_active Withdrawn
- 2006-05-29 CA CA2608702A patent/CA2608702C/en not_active Expired - Fee Related
- 2006-05-29 US US11/914,570 patent/US7666877B2/en not_active Expired - Fee Related
- 2006-05-29 JP JP2008513997A patent/JP5121703B2/ja not_active Expired - Fee Related
- 2006-05-29 AU AU2006254395A patent/AU2006254395B2/en not_active Ceased
- 2006-05-29 EP EP06753946A patent/EP1893611A1/en not_active Withdrawn
- 2006-05-29 BR BRPI0611489-0A patent/BRPI0611489A2/pt not_active IP Right Cessation
- 2006-05-29 CN CN2006800186451A patent/CN101184754B/zh not_active Expired - Fee Related
- 2006-05-29 RU RU2007147597/04A patent/RU2416613C2/ru not_active IP Right Cessation
- 2006-05-29 WO PCT/EP2006/005106 patent/WO2006128658A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1893611A1 (en) | 2008-03-05 |
| JP5121703B2 (ja) | 2013-01-16 |
| CN101184754B (zh) | 2010-12-22 |
| BRPI0611489A2 (pt) | 2010-11-23 |
| AU2006254395A1 (en) | 2006-12-07 |
| WO2006128658A1 (en) | 2006-12-07 |
| US20090018127A1 (en) | 2009-01-15 |
| US7666877B2 (en) | 2010-02-23 |
| CN101184754A (zh) | 2008-05-21 |
| RU2007147597A (ru) | 2009-07-20 |
| AU2006254395B2 (en) | 2010-09-09 |
| CA2608702C (en) | 2013-10-15 |
| RU2416613C2 (ru) | 2011-04-20 |
| GB0511060D0 (en) | 2005-07-06 |
| CA2608702A1 (en) | 2006-12-07 |
| JP2008545725A (ja) | 2008-12-18 |
| MX2007015084A (es) | 2008-01-17 |
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