BRPI0611489A2 - derivados de ergolina e seu uso como ligantes de receptores de quimiocinas - Google Patents
derivados de ergolina e seu uso como ligantes de receptores de quimiocinas Download PDFInfo
- Publication number
- BRPI0611489A2 BRPI0611489A2 BRPI0611489-0A BRPI0611489A BRPI0611489A2 BR PI0611489 A2 BRPI0611489 A2 BR PI0611489A2 BR PI0611489 A BRPI0611489 A BR PI0611489A BR PI0611489 A2 BRPI0611489 A2 BR PI0611489A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- optionally substituted
- compound
- heteroaryl
- alkyl
- Prior art date
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- 102000009410 Chemokine receptor Human genes 0.000 title claims abstract description 6
- 108050000299 Chemokine receptor Proteins 0.000 title claims abstract description 6
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract description 4
- 239000011230 binding agent Substances 0.000 title 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 12
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- 125000005842 heteroatom Chemical group 0.000 claims abstract description 9
- 208000035475 disorder Diseases 0.000 claims abstract description 7
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 2
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- 238000000746 purification Methods 0.000 description 6
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 6
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- Transplantation (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0511060.6A GB0511060D0 (en) | 2005-05-31 | 2005-05-31 | Organic compounds |
| GB0511060.6 | 2005-05-31 | ||
| PCT/EP2006/005106 WO2006128658A1 (en) | 2005-05-31 | 2006-05-29 | Ergoline derivatives and their use as chemokine receptor ligands |
Publications (1)
| Publication Number | Publication Date |
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| BRPI0611489A2 true BRPI0611489A2 (pt) | 2010-11-23 |
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Family Applications (1)
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| BRPI0611489-0A BRPI0611489A2 (pt) | 2005-05-31 | 2006-05-29 | derivados de ergolina e seu uso como ligantes de receptores de quimiocinas |
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| US (1) | US7666877B2 (https=) |
| EP (1) | EP1893611A1 (https=) |
| JP (1) | JP5121703B2 (https=) |
| KR (1) | KR20080013971A (https=) |
| CN (1) | CN101184754B (https=) |
| AU (1) | AU2006254395B2 (https=) |
| BR (1) | BRPI0611489A2 (https=) |
| CA (1) | CA2608702C (https=) |
| GB (1) | GB0511060D0 (https=) |
| MX (1) | MX2007015084A (https=) |
| RU (1) | RU2416613C2 (https=) |
| WO (1) | WO2006128658A1 (https=) |
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| IN2012DN04858A (https=) * | 2009-12-23 | 2015-09-25 | Map Pharmaceuticals Inc | |
| US9095591B2 (en) | 2010-06-28 | 2015-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Pharmaceutical composition for use in the treatment of glaucoma |
| KR20140042868A (ko) | 2011-06-23 | 2014-04-07 | 맵 파마슈티컬스, 인코포레이티드 | 신규한 플루오로에르골린 유사체 |
| SG10201509139QA (en) | 2011-12-19 | 2015-12-30 | Map Pharmaceuticals Inc | Novel iso-ergoline derivatives |
| CA2859175A1 (en) | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
| RU2014153672A (ru) * | 2012-06-22 | 2016-08-10 | Мап Фармасьютикалс, Инк. | Новые каберголиновые производные |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| MX2017009405A (es) | 2015-01-20 | 2018-01-18 | Xoc Pharmaceuticals Inc | Compuestos de tipo ergolina y usos de estos. |
| EP3247357A4 (en) | 2015-01-20 | 2018-07-11 | Xoc Pharmaceuticals, Inc | Isoergoline compounds and uses thereof |
| WO2018223065A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| EP4329759A4 (en) | 2021-04-30 | 2025-07-16 | Mind Medicine Inc | CRYSTALLINE FORMS OF LSD SALTS |
| US12611399B2 (en) | 2021-05-04 | 2026-04-28 | Definium Therapeutics US, Inc. | Movement disorders |
| JP7846211B2 (ja) | 2021-08-19 | 2026-04-14 | デフィニウム セラピューティクス ユーエス， インコーポレイテッド | 治療適用のためのｄ－リゼルグ酸ジエチルアミドの即時放出製剤 |
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| WO2000042071A2 (en) | 1999-01-12 | 2000-07-20 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| EP2070921A1 (en) | 2000-11-07 | 2009-06-17 | Novartis Ag | Indolylmaleimide derivatives as protein kinase c inhibitors |
| TW200918046A (en) | 2002-04-03 | 2009-05-01 | Novartis Ag | Indolylmaleimide derivatives |
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2005
- 2005-05-31 GB GBGB0511060.6A patent/GB0511060D0/en not_active Ceased
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2006
- 2006-05-29 MX MX2007015084A patent/MX2007015084A/es active IP Right Grant
- 2006-05-29 KR KR1020077027902A patent/KR20080013971A/ko not_active Withdrawn
- 2006-05-29 CA CA2608702A patent/CA2608702C/en not_active Expired - Fee Related
- 2006-05-29 US US11/914,570 patent/US7666877B2/en not_active Expired - Fee Related
- 2006-05-29 JP JP2008513997A patent/JP5121703B2/ja not_active Expired - Fee Related
- 2006-05-29 AU AU2006254395A patent/AU2006254395B2/en not_active Ceased
- 2006-05-29 EP EP06753946A patent/EP1893611A1/en not_active Withdrawn
- 2006-05-29 BR BRPI0611489-0A patent/BRPI0611489A2/pt not_active IP Right Cessation
- 2006-05-29 CN CN2006800186451A patent/CN101184754B/zh not_active Expired - Fee Related
- 2006-05-29 RU RU2007147597/04A patent/RU2416613C2/ru not_active IP Right Cessation
- 2006-05-29 WO PCT/EP2006/005106 patent/WO2006128658A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1893611A1 (en) | 2008-03-05 |
| JP5121703B2 (ja) | 2013-01-16 |
| CN101184754B (zh) | 2010-12-22 |
| AU2006254395A1 (en) | 2006-12-07 |
| WO2006128658A1 (en) | 2006-12-07 |
| US20090018127A1 (en) | 2009-01-15 |
| US7666877B2 (en) | 2010-02-23 |
| CN101184754A (zh) | 2008-05-21 |
| RU2007147597A (ru) | 2009-07-20 |
| AU2006254395B2 (en) | 2010-09-09 |
| CA2608702C (en) | 2013-10-15 |
| RU2416613C2 (ru) | 2011-04-20 |
| GB0511060D0 (en) | 2005-07-06 |
| CA2608702A1 (en) | 2006-12-07 |
| JP2008545725A (ja) | 2008-12-18 |
| KR20080013971A (ko) | 2008-02-13 |
| MX2007015084A (es) | 2008-01-17 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2310 DE 14-04-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |