KR20080013971A - 에르골린 유도체 및 케모카인 수용체 리간드로서 그의 용도 - Google Patents
에르골린 유도체 및 케모카인 수용체 리간드로서 그의 용도 Download PDFInfo
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- KR20080013971A KR20080013971A KR1020077027902A KR20077027902A KR20080013971A KR 20080013971 A KR20080013971 A KR 20080013971A KR 1020077027902 A KR1020077027902 A KR 1020077027902A KR 20077027902 A KR20077027902 A KR 20077027902A KR 20080013971 A KR20080013971 A KR 20080013971A
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- 239000003446 ligand Substances 0.000 title claims abstract description 16
- 102000009410 Chemokine receptor Human genes 0.000 title claims abstract description 8
- 108050000299 Chemokine receptor Proteins 0.000 title claims abstract description 8
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- -1 heteroaryl N-oxides Chemical class 0.000 claims abstract description 27
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
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- 125000006552 (C3-C8) cycloalkyl group Chemical class 0.000 claims abstract description 4
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- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
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- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
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- 239000008346 aqueous phase Substances 0.000 description 4
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- 239000003018 immunosuppressive agent Substances 0.000 description 4
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
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- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Urology & Nephrology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0511060.6A GB0511060D0 (en) | 2005-05-31 | 2005-05-31 | Organic compounds |
| GB0511060.6 | 2005-05-31 |
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| Publication Number | Publication Date |
|---|---|
| KR20080013971A true KR20080013971A (ko) | 2008-02-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020077027902A Withdrawn KR20080013971A (ko) | 2005-05-31 | 2006-05-29 | 에르골린 유도체 및 케모카인 수용체 리간드로서 그의 용도 |
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| US (1) | US7666877B2 (enExample) |
| EP (1) | EP1893611A1 (enExample) |
| JP (1) | JP5121703B2 (enExample) |
| KR (1) | KR20080013971A (enExample) |
| CN (1) | CN101184754B (enExample) |
| AU (1) | AU2006254395B2 (enExample) |
| BR (1) | BRPI0611489A2 (enExample) |
| CA (1) | CA2608702C (enExample) |
| GB (1) | GB0511060D0 (enExample) |
| MX (1) | MX2007015084A (enExample) |
| RU (1) | RU2416613C2 (enExample) |
| WO (1) | WO2006128658A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SG181896A1 (en) * | 2009-12-23 | 2012-07-30 | Map Pharmaceuticals Inc | Novel ergoline analogs |
| JP5874124B2 (ja) | 2010-06-28 | 2016-03-02 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 緑内障の処置に使用するための薬学的組成物 |
| CA2838991A1 (en) | 2011-06-23 | 2012-12-27 | Map Pharmaceuticals, Inc. | Novel fluoroergoline analogs |
| CA2859173A1 (en) | 2011-12-19 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel iso-ergoline derivatives |
| WO2013095708A1 (en) | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
| AU2012382929A1 (en) * | 2012-06-22 | 2015-02-05 | Map Pharmaceuticals, Inc. | Novel cabergoline derivatives |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| CN113149982A (zh) | 2015-01-20 | 2021-07-23 | Xoc制药股份有限公司 | 麦角灵化合物及其用途 |
| AU2016209490B2 (en) | 2015-01-20 | 2020-09-03 | Xoc Pharmaceuticals, Inc. | Isoergoline compounds and uses thereof |
| EP3630758A1 (en) | 2017-06-01 | 2020-04-08 | Xoc Pharmaceuticals, Inc | Ergoline derivatives for use in medicine |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| WO2020212951A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
| WO2022232093A1 (en) | 2021-04-30 | 2022-11-03 | Mind Medicine, Inc. | Lsd salt crystal forms |
| AU2022331317B2 (en) | 2021-08-19 | 2025-09-11 | Definium Therapeutics US, Inc. | IMMEDIATE RELEASE FORMULATIONS OF d-LYSERGIC ACID DIETHYLAMIDE FOR THERAPEUTIC APPLICATIONS |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000042071A2 (en) * | 1999-01-12 | 2000-07-20 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| RU2329263C2 (ru) | 2000-11-07 | 2008-07-20 | Новартис Аг | Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с |
| AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
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2005
- 2005-05-31 GB GBGB0511060.6A patent/GB0511060D0/en not_active Ceased
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2006
- 2006-05-29 US US11/914,570 patent/US7666877B2/en not_active Expired - Fee Related
- 2006-05-29 JP JP2008513997A patent/JP5121703B2/ja not_active Expired - Fee Related
- 2006-05-29 CA CA2608702A patent/CA2608702C/en not_active Expired - Fee Related
- 2006-05-29 KR KR1020077027902A patent/KR20080013971A/ko not_active Withdrawn
- 2006-05-29 RU RU2007147597/04A patent/RU2416613C2/ru not_active IP Right Cessation
- 2006-05-29 EP EP06753946A patent/EP1893611A1/en not_active Withdrawn
- 2006-05-29 CN CN2006800186451A patent/CN101184754B/zh not_active Expired - Fee Related
- 2006-05-29 BR BRPI0611489-0A patent/BRPI0611489A2/pt not_active IP Right Cessation
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- 2006-05-29 WO PCT/EP2006/005106 patent/WO2006128658A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007147597A (ru) | 2009-07-20 |
| CA2608702A1 (en) | 2006-12-07 |
| EP1893611A1 (en) | 2008-03-05 |
| MX2007015084A (es) | 2008-01-17 |
| BRPI0611489A2 (pt) | 2010-11-23 |
| JP5121703B2 (ja) | 2013-01-16 |
| RU2416613C2 (ru) | 2011-04-20 |
| WO2006128658A1 (en) | 2006-12-07 |
| CA2608702C (en) | 2013-10-15 |
| GB0511060D0 (en) | 2005-07-06 |
| JP2008545725A (ja) | 2008-12-18 |
| CN101184754B (zh) | 2010-12-22 |
| US20090018127A1 (en) | 2009-01-15 |
| AU2006254395B2 (en) | 2010-09-09 |
| US7666877B2 (en) | 2010-02-23 |
| CN101184754A (zh) | 2008-05-21 |
| AU2006254395A1 (en) | 2006-12-07 |
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| PC1203 | Withdrawal of no request for examination | ||
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