CN101184754B - 麦角灵衍生物和其作为趋化因子受体配体的用途 - Google Patents

麦角灵衍生物和其作为趋化因子受体配体的用途 Download PDF

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Publication number
CN101184754B
CN101184754B CN2006800186451A CN200680018645A CN101184754B CN 101184754 B CN101184754 B CN 101184754B CN 2006800186451 A CN2006800186451 A CN 2006800186451A CN 200680018645 A CN200680018645 A CN 200680018645A CN 101184754 B CN101184754 B CN 101184754B
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compound
optionally substituted
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substituted
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CN101184754A (zh
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R·巴特里
F·格利克曼
J·科瓦里克
I·刘易斯
M·施特赖夫
G·托马
H-G·策尔韦斯
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
CN2006800186451A 2005-05-31 2006-05-29 麦角灵衍生物和其作为趋化因子受体配体的用途 Expired - Fee Related CN101184754B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0511060.6A GB0511060D0 (en) 2005-05-31 2005-05-31 Organic compounds
GB0511060.6 2005-05-31
PCT/EP2006/005106 WO2006128658A1 (en) 2005-05-31 2006-05-29 Ergoline derivatives and their use as chemokine receptor ligands

Publications (2)

Publication Number Publication Date
CN101184754A CN101184754A (zh) 2008-05-21
CN101184754B true CN101184754B (zh) 2010-12-22

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CN2006800186451A Expired - Fee Related CN101184754B (zh) 2005-05-31 2006-05-29 麦角灵衍生物和其作为趋化因子受体配体的用途

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Country Link
US (1) US7666877B2 (enExample)
EP (1) EP1893611A1 (enExample)
JP (1) JP5121703B2 (enExample)
KR (1) KR20080013971A (enExample)
CN (1) CN101184754B (enExample)
AU (1) AU2006254395B2 (enExample)
BR (1) BRPI0611489A2 (enExample)
CA (1) CA2608702C (enExample)
GB (1) GB0511060D0 (enExample)
MX (1) MX2007015084A (enExample)
RU (1) RU2416613C2 (enExample)
WO (1) WO2006128658A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG181896A1 (en) * 2009-12-23 2012-07-30 Map Pharmaceuticals Inc Novel ergoline analogs
JP5874124B2 (ja) 2010-06-28 2016-03-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 緑内障の処置に使用するための薬学的組成物
CA2838991A1 (en) 2011-06-23 2012-12-27 Map Pharmaceuticals, Inc. Novel fluoroergoline analogs
CA2859173A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
WO2013095708A1 (en) 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
AU2012382929A1 (en) * 2012-06-22 2015-02-05 Map Pharmaceuticals, Inc. Novel cabergoline derivatives
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
CN113149982A (zh) 2015-01-20 2021-07-23 Xoc制药股份有限公司 麦角灵化合物及其用途
AU2016209490B2 (en) 2015-01-20 2020-09-03 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
EP3630758A1 (en) 2017-06-01 2020-04-08 Xoc Pharmaceuticals, Inc Ergoline derivatives for use in medicine
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2020212951A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
WO2022232093A1 (en) 2021-04-30 2022-11-03 Mind Medicine, Inc. Lsd salt crystal forms
AU2022331317B2 (en) 2021-08-19 2025-09-11 Definium Therapeutics US, Inc. IMMEDIATE RELEASE FORMULATIONS OF d-LYSERGIC ACID DIETHYLAMIDE FOR THERAPEUTIC APPLICATIONS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042071A2 (en) * 1999-01-12 2000-07-20 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2329263C2 (ru) 2000-11-07 2008-07-20 Новартис Аг Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с
AR039209A1 (es) 2002-04-03 2005-02-09 Novartis Ag Derivados de indolilmaleimida

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042071A2 (en) * 1999-01-12 2000-07-20 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
YUji NAKAHARA AND TETSUKICHI NIWAGUCHI.studies on lysergic acid diethylamide and related compoundsI.synthesis of d-N6-demethyl-lysergic acid diethylamide.CHEM.PHARM.BULL19 11.1971,19(11),2337-2341.
YUji NAKAHARA AND TETSUKICHI NIWAGUCHI.studies on lysergic acid diethylamide and related compoundsI.synthesis of d-N6-demethyl-lysergic acid diethylamide.CHEM.PHARM.BULL19 11.1971,19(11),2337-2341. *

Also Published As

Publication number Publication date
RU2007147597A (ru) 2009-07-20
CA2608702A1 (en) 2006-12-07
EP1893611A1 (en) 2008-03-05
MX2007015084A (es) 2008-01-17
BRPI0611489A2 (pt) 2010-11-23
JP5121703B2 (ja) 2013-01-16
RU2416613C2 (ru) 2011-04-20
WO2006128658A1 (en) 2006-12-07
CA2608702C (en) 2013-10-15
KR20080013971A (ko) 2008-02-13
GB0511060D0 (en) 2005-07-06
JP2008545725A (ja) 2008-12-18
US20090018127A1 (en) 2009-01-15
AU2006254395B2 (en) 2010-09-09
US7666877B2 (en) 2010-02-23
CN101184754A (zh) 2008-05-21
AU2006254395A1 (en) 2006-12-07

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