KR20080008378A - 크로만 및 크로멘 유도체 및 이의 용도 - Google Patents
크로만 및 크로멘 유도체 및 이의 용도 Download PDFInfo
- Publication number
- KR20080008378A KR20080008378A KR1020077027247A KR20077027247A KR20080008378A KR 20080008378 A KR20080008378 A KR 20080008378A KR 1020077027247 A KR1020077027247 A KR 1020077027247A KR 20077027247 A KR20077027247 A KR 20077027247A KR 20080008378 A KR20080008378 A KR 20080008378A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- methyl
- compound
- mmol
- chromen
- Prior art date
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- 0 C*C(C)(C=C)Oc1c(CC=C)cc(C)cc1[Al] Chemical compound C*C(C)(C=C)Oc1c(CC=C)cc(C)cc1[Al] 0.000 description 2
- UBGCITIGQHGMHV-OAHLLOKOSA-N CC(C)Oc1cc(F)ccc1-c1cccc2c1O[C@@H](CN)CC2 Chemical compound CC(C)Oc1cc(F)ccc1-c1cccc2c1O[C@@H](CN)CC2 UBGCITIGQHGMHV-OAHLLOKOSA-N 0.000 description 1
- JXMLNDVCUABJPW-UHFFFAOYSA-N CCc1cccc(C)c1-c1c2OCCCc2ccc1 Chemical compound CCc1cccc(C)c1-c1c2OCCCc2ccc1 JXMLNDVCUABJPW-UHFFFAOYSA-N 0.000 description 1
- POWDDLYJHKKDAY-UHFFFAOYSA-N COc(cc(cc1)F)c1-c1cccc2c1OCCC2 Chemical compound COc(cc(cc1)F)c1-c1cccc2c1OCCC2 POWDDLYJHKKDAY-UHFFFAOYSA-N 0.000 description 1
- YNAGCCKYAGVFAR-CYBMUJFWSA-N COc(cc1)cc(Cl)c1-c1cc(F)cc2c1O[C@@H](CN)CC2 Chemical compound COc(cc1)cc(Cl)c1-c1cc(F)cc2c1O[C@@H](CN)CC2 YNAGCCKYAGVFAR-CYBMUJFWSA-N 0.000 description 1
- NYQFZDLCSXLHKU-UHFFFAOYSA-N Cc(cc(cc1)OC)c1-c1c2OCCCc2cc(F)c1 Chemical compound Cc(cc(cc1)OC)c1-c1c2OCCCc2cc(F)c1 NYQFZDLCSXLHKU-UHFFFAOYSA-N 0.000 description 1
- UCHYVRJUUWPOQR-UHFFFAOYSA-N Cc(cc1C(F)(F)F)ccc1-c1cc(F)cc2c1OCCC2 Chemical compound Cc(cc1C(F)(F)F)ccc1-c1cc(F)cc2c1OCCC2 UCHYVRJUUWPOQR-UHFFFAOYSA-N 0.000 description 1
- GDLNAGWXZRQZPC-UHFFFAOYSA-N FC(c(cccc1)c1-c1cccc2c1OCCC2)(F)F Chemical compound FC(c(cccc1)c1-c1cccc2c1OCCC2)(F)F GDLNAGWXZRQZPC-UHFFFAOYSA-N 0.000 description 1
- NLNMXMNZJZXFAG-UHFFFAOYSA-N N#Cc(cc(cc1)F)c1-c1c2OCCCc2ccc1 Chemical compound N#Cc(cc(cc1)F)c1-c1c2OCCCc2ccc1 NLNMXMNZJZXFAG-UHFFFAOYSA-N 0.000 description 1
- PXFVSUMXEOMMOS-LLVKDONJSA-N NC[C@@H](CC1)Oc(c(-c(c(Cl)ccc2)c2F)c2)c1cc2F Chemical compound NC[C@@H](CC1)Oc(c(-c(c(Cl)ccc2)c2F)c2)c1cc2F PXFVSUMXEOMMOS-LLVKDONJSA-N 0.000 description 1
- FZNBEDOOVRSKMV-GFCCVEGCSA-N NC[C@@H](CC1)Oc(c(-c(cccc2)c2OC(F)(F)F)c2)c1cc2F Chemical compound NC[C@@H](CC1)Oc(c(-c(cccc2)c2OC(F)(F)F)c2)c1cc2F FZNBEDOOVRSKMV-GFCCVEGCSA-N 0.000 description 1
- JNLSYXZVFCMCKO-GFCCVEGCSA-N NC[C@@H](CC1)Oc2c1cccc2-c1cc(C(F)(F)F)ccc1C(F)(F)F Chemical compound NC[C@@H](CC1)Oc2c1cccc2-c1cc(C(F)(F)F)ccc1C(F)(F)F JNLSYXZVFCMCKO-GFCCVEGCSA-N 0.000 description 1
- ZXNDXFTZHZTQNU-GFCCVEGCSA-N NC[C@@H](CC1)Oc2c1cccc2-c1ccccc1Cl Chemical compound NC[C@@H](CC1)Oc2c1cccc2-c1ccccc1Cl ZXNDXFTZHZTQNU-GFCCVEGCSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67382005P | 2005-04-22 | 2005-04-22 | |
| US60/673,820 | 2005-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080008378A true KR20080008378A (ko) | 2008-01-23 |
Family
ID=36888961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077027247A KR20080008378A (ko) | 2005-04-22 | 2006-04-21 | 크로만 및 크로멘 유도체 및 이의 용도 |
Country Status (19)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014204064A1 (ko) * | 2013-06-21 | 2014-12-24 | 제주대학교 산학협력단 | 신규 플라보노이드 및 그 용도 |
| EP3923919A4 (en) * | 2019-02-17 | 2022-12-07 | Neurawell Therapeutics | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION AND OTHER DISORDERS |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
| GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
| PE20061298A1 (es) * | 2005-04-22 | 2006-12-24 | Wyeth Corp | Compuestos derivados de dihidrobenzofurano como agonistas del receptor de serotonina 5-ht2c |
| JP2008538575A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ベンゾジオキサンおよびベンゾジオキソラン誘導体ならびにそれらの使用 |
| AU2006239900A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Therapeutic combinations for the treatment or prevention of psychotic disorders |
| CA2605554A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists |
| AR056320A1 (es) * | 2005-04-22 | 2007-10-03 | Wyeth Corp | Derivados de cromano y cromeno, procesos de obtencion, composiciones farmaceuticas y usos de los mismos |
| CN101203216A (zh) * | 2005-04-22 | 2008-06-18 | 惠氏公司 | 二氢苯并呋喃衍生物及其用途 |
| WO2006116149A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | New therapeutic combianations for the treatment or prevention of depression |
| MX2007013065A (es) * | 2005-04-22 | 2008-01-14 | Wyeth Corp | Derivados de dihidrobenzofurano y usos de los mismos. |
| GT200600160A (es) * | 2005-04-22 | 2007-03-14 | Tratamiento del dolor | |
| EP1874292A2 (en) * | 2005-04-24 | 2008-01-09 | Wyeth | Methods for modulating bladder function |
| PE20080172A1 (es) * | 2006-03-24 | 2008-04-21 | Wyeth Corp | Compuestos dihidrobenzofuranil alcanamida como moduladores del receptor 5-ht2c |
| TW200815388A (en) * | 2006-04-18 | 2008-04-01 | Wyeth Corp | Chromane and chromene derivatives and uses thereof |
| EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| CL2007003043A1 (es) * | 2006-10-24 | 2008-05-30 | Wyeth Corp | Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros. |
| WO2008052088A1 (en) * | 2006-10-25 | 2008-05-02 | Wyeth | Chromane derivatives, synthesis thereof, and intermediates thereto |
| EP2197532A1 (en) | 2007-08-06 | 2010-06-23 | Serenity Pharmaceuticals Corporation | Methods and devices for desmopressin drug delivery |
| WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
| US8914112B2 (en) | 2008-01-23 | 2014-12-16 | Boston Scienctific Neuromodulation Corporation | Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction |
| US8676322B2 (en) | 2008-01-30 | 2014-03-18 | Boston Scientific Neuromodulation Corporation | Methods and systems of treating pancreatitis pain |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| NO2296686T3 (US20060258714A1-20061116-C00091.png) | 2008-05-21 | 2014-07-12 | ||
| EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
| CN101921252B (zh) * | 2010-07-02 | 2012-05-09 | 中国科学院上海有机化学研究所 | 1-氧杂苯并杂环类化合物、合成方法和用途 |
| MX344516B (es) | 2010-12-21 | 2016-12-19 | Colgate Palmolive Co | Bifenoles halogenados como agentes antibacterianos. |
| CN104854068A (zh) * | 2012-12-18 | 2015-08-19 | 帝斯曼知识产权资产管理有限公司 | 由(r)-6,10-14-三甲基十五碳-5-烯-2-酮制备的(6r,10r)-6,10,14-三甲基十五烷-2-酮 |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
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- 2006-04-21 EP EP06758490A patent/EP1874756A1/en not_active Withdrawn
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- 2006-04-21 BR BRPI0610027-9A patent/BRPI0610027A2/pt not_active Application Discontinuation
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- 2006-04-21 TW TW095114313A patent/TW200716595A/zh unknown
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014204064A1 (ko) * | 2013-06-21 | 2014-12-24 | 제주대학교 산학협력단 | 신규 플라보노이드 및 그 용도 |
| EP3923919A4 (en) * | 2019-02-17 | 2022-12-07 | Neurawell Therapeutics | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION AND OTHER DISORDERS |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080182891A1 (en) | 2008-07-31 |
| RU2007139541A (ru) | 2009-05-27 |
| BRPI0610027A2 (pt) | 2010-05-18 |
| US20060258714A1 (en) | 2006-11-16 |
| CO6321153A2 (es) | 2011-09-20 |
| EP1874756A1 (en) | 2008-01-09 |
| AR056320A1 (es) | 2007-10-03 |
| GT200600166A (es) | 2007-03-14 |
| ZA200709052B (en) | 2009-08-26 |
| JP2008538576A (ja) | 2008-10-30 |
| PE20061297A1 (es) | 2006-12-24 |
| US7365095B2 (en) | 2008-04-29 |
| NO20075641L (no) | 2007-11-20 |
| MX2007013163A (es) | 2008-01-21 |
| TW200716595A (en) | 2007-05-01 |
| WO2006116165A1 (en) | 2006-11-02 |
| IL186837A0 (en) | 2008-02-09 |
| CA2605587A1 (en) | 2006-11-02 |
| CN101203505A (zh) | 2008-06-18 |
| AU2006239937A1 (en) | 2006-11-02 |
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