KR20070098315A - Whithening and moisturizing cosmetics composition comprising of kyeong-ok-go - Google Patents

Whithening and moisturizing cosmetics composition comprising of kyeong-ok-go Download PDF

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KR20070098315A
KR20070098315A KR1020060029825A KR20060029825A KR20070098315A KR 20070098315 A KR20070098315 A KR 20070098315A KR 1020060029825 A KR1020060029825 A KR 1020060029825A KR 20060029825 A KR20060029825 A KR 20060029825A KR 20070098315 A KR20070098315 A KR 20070098315A
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jadeite
whitening
skin
moisturizing
herb medicine
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최승오
박혁구
고인수
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농업회사법인 하나바이오텍(주)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
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  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

A composition comprising a herb medicine(Gyeongokgo) or a solubilized a herb medicine(Gyeongokgo) is provided to show skin whitening effect without skin side effects, thereby being effective as whitening and moisturizing cosmetics. A composition for whitening and moisturizing comprises a herb medicine(Gyeongokgo) for promoting blood circulation consisting of Rehmanniae Radix Crudus, Panax ginseng, Poria cocos Wolf and honey or the herb medicine prepared by crushing the herb medicine and hydrolyzing it with water and a hydrophilic solvent and a conventional cosmetic composition.

Description

경옥고를 함유하는 미백 및 보습 화장료 조성물{Whithening and moisturizing cosmetics composition comprising of Kyeong-Ok-Go}Whiting and moisturizing cosmetics composition comprising of Kyeong-Ok-Go}

본 발명은 미백 및 보습 화장료 조성물에 관한 것으로, 더욱 상세하게는 종래의 화장료 조성물에 생지황, 인삼, 백복령, 꿀로 조성되어진 경옥고 혹은 이를 미세 분쇄하여 물 및 친수성 용매로 가용화시킨 경옥고를 함유하는 것으로 미백 및 보습효과를 나타내기 위한 화장료 조성물에 관한 것이다.The present invention relates to a whitening and moisturizing cosmetic composition, and more particularly, to a conventional cosmetic composition containing jadeite, ginseng, ginseng, baekbokyeong, honey, or jadeite finely pulverized and solubilized with water and a hydrophilic solvent. It relates to a cosmetic composition for showing a moisturizing effect.

사람은 자외선을 받으면 피부를 보호하기 위한 작용에 의해서 피부가 검게 된다. 즉, 자외선에 의해서, 멜라닌을 만들어내는 멜라노사이트 세포 내의 효소가 활성화되어 흑색의 멜라닌 색소가 생성되어 피부가 검어지게 된다. 여기서 멜라닌 색소의 과다 생성이 기미, 주근깨의 원인을 제공한다. 이와같이 외관상의 문제를 해결하기 위해서는 미백 화장품이 요구되게 된다. When a person receives ultraviolet rays, the skin becomes black due to the action of protecting the skin. In other words, the ultraviolet rays, the enzyme in the melanocytes that produce melanin is activated to produce a black melanin pigment, blackening the skin. Here, the excessive production of melanin pigments provide the cause of spots and freckles. As such, whitening cosmetics are required to solve the cosmetic problem.

지금까지의 멜라닌 색소 생성 저해제로는 레티노이드, 알부틴, 하이드로퀴논, 코지산 등 매우 다양하나, 그 안정성과 경제성 그리고 부작용 등의 문제로 사용에 있어서는 어려움이 있었다. Until now, melanin pigment production inhibitors, such as retinoids, arbutin, hydroquinone, kojic acid are very diverse, but there are difficulties in use due to problems such as stability and economics and side effects.

동의보감에서의 경옥고의 인체에 대한 효능은 모발을 검게 하고 치아를 나게 하며, 젊음을 유지시켜 주며, 정신이 좋아지고 오장이 충실해진다라고 기록되어 있다. 동의보감에서의 경옥고의 처방내용은 생지황 6.4kg, 인삼 960g, 백복령 1,920g에 꿀 4Kg을 고루 섞어서 4주 동안 끓여서 만드는 것이다.It has been documented that the effect of Kyung Okgo on human body in black tea is blackening hair, teething, maintaining youthfulness, improving mentality, and improving five senses. The prescription of Kyungokgo in Dongbogam is to make 4kg of honey mixed with 6.4kg of raw sulfur, 960g of ginseng, and 1,920g of Baekbokryeong and boil for 4 weeks.

경옥고 속의 성분 중, 피부에 좋은 영향을 줄 수 있는 성분으로는 꿀의 다양한 영양공급과 보습, 베타글루칸에 의해 피부의 면역 증강에 도움을 주는 백복령, 피부의 항산화 및 미백에 도움을 주는 사포닌이 다량 함유되어 있는 인삼 등을 들 수가 있다.Among the components of the jadeite, which can have a good effect on the skin, there are various nutrients and moisturizing of honey, Baekbokryeong which helps to boost the skin's immunity by beta glucan, and saponin which helps the skin's antioxidant and whitening. And ginseng contained.

이에 본 발명은 기존의 미백물질의 안정성 및 경제성, 부작용의 문제점을 극복하기 위하여 한방의 집대성인 동의보감에 기록된 경옥고가 우수한 피부 미백 및 보습효과가 뛰어나다는 연구결과를 얻었고, 구체적으로는 멜라닌 생성억제 효과 및 피부 보호막 형성에 따른 보습효과를 갖는다는 연구결과를 얻게되어 본 발명을 완성하게 되었다. In order to overcome the problems of stability, economical efficiency and side effects of the existing whitening materials, the present invention has obtained research findings that jadeite is excellent in skin whitening and moisturizing effects recorded in Dongbobom, which is a collective herbal medicine, and specifically inhibits melanin production. The result of the research and the moisturizing effect according to the formation of the skin protective film was obtained to complete the present invention.

떠라서, 본 발명의 목적은 피부자극이 없는 천연물로서 미백과 보습 효능이 뛰어난 수용성 경옥고를 함유하는 미백 및 보습 화장료 조성물을 제공하고자 한다. 특히, 여기서 사용하는 경옥고는 고형분이 약 50% 함유하는 매우 점도 높은 액상으로 피부 침투가 좋지 않기 때문에 경옥고 중량%에 물 20배 희석 후, 80도에서 일정시간 추출함으로써 피부 침투를 더욱 용이하게 하는 것도 그 하나의 특징으로 하는 기술을 제공하게 되었다.Therefore, an object of the present invention is to provide a whitening and moisturizing cosmetic composition containing water-soluble jadeite having excellent whitening and moisturizing efficacy as a natural product without skin irritation. In particular, the jadeite used here is a very viscous liquid containing about 50% of solids, so skin penetration is not good, and after diluting water by 20 times with jadeite weight by 20 times, extracting at 80 ° C for a certain period of time makes skin penetration easier. One feature is to provide a technology.

본 발명은 미백 및 보습 화장료 조성물에 관한 것으로, 더욱 상세하게는 종래의 화장료 조성물에 생지황, 인삼, 백복령, 꿀로 조성되어진 경옥고 혹은 이를 미세 분쇄하여 물 및 친수성 용매로 가용화시킨 경옥고를 함유하는 것으로 미백 및 보습효과를 나타내기 위한 화장료 조성물에 관한 것이다.The present invention relates to a whitening and moisturizing cosmetic composition, and more particularly, to a conventional cosmetic composition containing jadeite, ginseng, ginseng, baekbokyeong, honey, or jadeite finely pulverized and solubilized with water and a hydrophilic solvent. It relates to a cosmetic composition for showing a moisturizing effect.

본 발명은 동의보감의 제조법으로 제조돤 경옥고 추출물과 (1) 경옥고를 영하 20-40도의 조건 하에서 동결건조 혹은 60-80도의 조건 하에서 열품 건조한 후, 건조된 경옥고를 미분쇄한 후, (2) 상기 (1)에서 수득한 경옥고 미세분말을 중량기준 물의 양을 10-20배 혼합하여 80도의 온도에서 12시간-24시간 추출한 후, (3) 상기 제조된 추출물을 원심분리 하여, 불용화물을 모두 제거한 후, (4)얻어진 경옥고 액상을 영하 20-40도의 조건 하에서 동결건조하여 얻은 가용성 경옥고를 그 원료로 사용하는 화장료를 말하는 것이다. The present invention is prepared by the method of producing a synonymous bodhisattva extract and (1) after lyophilization or lyophilization under the conditions of minus 20-40 degrees and lyophilized under the conditions of minus 20-40 degrees, after pulverizing dried jadeite, The jadeite fine powder obtained in (1) was mixed with 10-20 times the amount of water by weight, and extracted for 12 hours to 24 hours at a temperature of 80 degrees. (3) The prepared extract was centrifuged to remove all insolubles. Then, (4) refers to a cosmetic using the soluble jadeite obtained by freeze-drying the obtained jadeite liquid phase under the condition of minus 20-40 degrees.

본 발명에서 사용하는 경옥고는 동의보감 상의 제조법에 의한 경옥고와 가용화 한 경옥고 추출물을 사용하여 상기의 목적을 달성하기 위한 것을 특징으로 한다.The jadeite used in the present invention is characterized by using the jadeite and the solubilized jadeite extract by the preparation method of synonymity and to achieve the above object.

이하 본 발명을 보다 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.

경옥고는 생지황(48%),인삼(7%), 백복령(15%), 꿀(30%)로 구성되어 있다. Gyeongokgo is composed of fresh green sulfur (48%), ginseng (7%), baekbokyeong (15%) and honey (30%).

생지황은 몸의 열을 내리는 한약재로 널리 사용되고 있어, 피부를 시원하게 하는 기능이 있다.Saengjihwang is widely used as a herbal medicine to lower the heat of the body, it has a function to cool the skin.

인삼은 항산화 및 피부 면역에 도움을 주는 사포닌이 다량 함유되어 있고, 피부 보습에도 좋은 영향을 준다. 특히, 인삼은 꿀과 함께 열을 가함으로써 다양한 종류의 사포닌이 생성되고, 함량도 높아지게 된다.Ginseng contains a large amount of saponin, which helps with antioxidants and skin immunity. In particular, ginseng is a variety of saponins produced by applying heat with honey, the content is also increased.

백복령은 피부 면역력을 높이는 베타글루칸이 다량 함유되어 있어 피부의 트러블 개선에 효과적이다.Baekbokryeong contains a large amount of beta glucan, which enhances skin immunity, and is effective in improving skin troubles.

꿀은 많은 천연 미네랄을 가지고 있으며, 다른 천연물들과 함께 가열을 하게 되면 수많은 항산화 물질들을 새롭게 생성하도록 도움을 주는 매우 좋은 천연물이다. 특히, 피부에 피막을 형성하여 피부의 수분증발을 막아주는 효과가 매우 크다.Honey has a lot of natural minerals, and when heated with other natural products, it is a very good natural product that helps to produce a lot of antioxidants. In particular, by forming a film on the skin is very effective in preventing moisture of the skin.

아래의 실시예, 제조예, 시험예를 통해서 본 발명의 내용을 구체적으로 설명을 하나, 본 발명의 내용이 여기에 한정되지 않음을 밝혀둔다.Although the content of the present invention will be described in detail through the following examples, preparation examples, and test examples, it should be understood that the content of the present invention is not limited thereto.

실시예1.Example 1

경옥고 100g을 80도의 온도에서 열풍 건조한 후, 100멧쉬로 분쇄하여 50g의 분말을 수득하였다. 수득한 경옥고 추출분발을 100cc의 물에 녹여 80도에서 12시간 가열을 한 후, 원심분리하여 불용 성분을 제거한 후, 영하 40도에서 동결건조 하여 10g의 가용성 경옥고 추출분말을 수득하였다. 100 g of jadeite was hot-air dried at a temperature of 80 degrees, and then pulverized with 100 mesh to obtain 50 g of powder. The obtained jadeite extract powder was dissolved in 100cc of water, heated at 80 ° C for 12 hours, centrifuged to remove insoluble components, and lyophilized at -40 ° C to obtain 10g of soluble jadeite extract powder.

실시예2.Example 2.

경옥고 100g을 80도의 온도에서 열품 건조한 후, 325멧쉬로 분쇄하여 50g의 분말을 수득하였다. 수득한 경옥고 추출분발을 200cc의 물에 녹여 80도에서 24시간 가열을 한 후, 원심분리하여 불용 성분을 제거한 후, 영하 40도에서 동결건조 하여 13g의 가용성 경옥고 추출분말을 수득하였다. 100 g of jadeite was hot dried at a temperature of 80 degrees and then pulverized with 325 mesh to obtain 50 g of powder. The obtained jadeite extract powder was dissolved in 200cc of water, heated at 80 ° C for 24 hours, centrifuged to remove insoluble components, and lyophilized at -40 ° C to obtain 13g of soluble jadeite extract powder.

제조예.Preparation example.

본 발명의 조성물은 화장품 제조분야에서 일반적으로 사용되는 보조제를 사 용하여 통상적으로 이용되는 방법에 따라 영양크림, 엣센스, 마스크팩, 화장비누를 제조하였다. 본발명의 가용성 경옥고 추출물을 함유하는 화장료의 제조예를 1-4를 통해 나타냈다.The composition of the present invention prepared nutrition cream, essence, mask pack, cosmetic soap in accordance with the method commonly used using auxiliaries commonly used in the cosmetic manufacturing field. The preparation example of the cosmetic containing the soluble jadeite extract of this invention was shown through 1-4.

1.영양크림1. Nutrition Cream

원료Raw material 실시예1(중량%)Example 1 (% by weight) 실시예2(중량%)Example 2 (% by weight) 가용성 경옥고 추출물Soluble jadeite extract 1.01.0 1.01.0 글리세린glycerin 10.010.0 10.010.0 부틸렌글리콜Butylene glycol 5.05.0 5.05.0 스쿠알렌Squalene 5.05.0 5.05.0 정재수Jaesoo Jung 79.079.0 79.079.0

2.엣센스2.Essence

원료Raw material 실시예1(중량%)Example 1 (% by weight) 실시예2(중량%)Example 2 (% by weight) 가용성 경옥고 추출물Soluble jadeite extract 2.02.0 2.02.0 글리세린glycerin 5.05.0 5.05.0 부틸렌글리콜Butylene glycol 2.02.0 2.02.0 스쿠알란Squalane 3.03.0 3.03.0 정제수Purified water 88.088.0 88.088.0

3.마스크팩3.mask pack

원료Raw material 실시예1(중량%)Example 1 (% by weight) 실시예2(중량%)Example 2 (% by weight) 가용성 경옥고 추출물Soluble jadeite extract 0.50.5 0.50.5 글리세린glycerin 1.51.5 1.51.5 부틸렌글리콜Butylene glycol 1.01.0 1.01.0 스쿠알란Squalane 2.02.0 2.02.0 정제수Purified water 95.095.0 95.095.0

4.화장비누4.Shoe equipment

원료Raw material 실시예1(중량%)Example 1 (% by weight) 실시예2(중량%)Example 2 (% by weight) 가용성 경옥고 추출물Soluble jadeite extract 1.51.5 1.51.5 글리세린glycerin 1.01.0 1.01.0 토코페롤Tocopherol 0.50.5 0.50.5 스쿠알란Squalane 2.02.0 2.02.0 솝베이스Shock base 95.095.0 95.095.0

실험예1.Experimental Example 1.

멜라노마 세포를 이용한 멜라닌 생성 저해 실험Melanin production inhibition experiment using melanoma cells

B16F19 마우스 멜라노마 세포를 규정된 조건에서 배양하였다. 평가방법은 다 음과 같다.멜라노마세포를 1.5*10³ cells/ml의 농도로 10% FBS를 포함하는 DMEM에 현탁시킨 후, 현탁세포 5ml를 tissue culture flask에 넣고, 시료를 첨가한 후, 5% CO2조건 하에서 37도로 배양하였다. 5일간 배양 후, phosphate buffered saline으로 씻고 trypsinization하였다. 세포를 corning Tube에 모은 후 PBS용액으로 씻고, 1*1,000,000 cells/mL 세포수당 1N NaOH용액 1ml을 넣어 세포를 녹인 다음, Microplate reader로 490nm에서 흡광도를 측정하여 멜라닌 생성 저해율을 평가하였다.B16F19 mouse melanoma cells were cultured under defined conditions. The evaluation method was as follows. After the melanoma cells were suspended in DMEM containing 10% FBS at a concentration of 1.5 * 10³ cells / ml, 5 ml of the suspended cells were placed in a tissue culture flask, and 5 samples were added. Incubated at 37 ° C under% CO2 After incubation for 5 days, washed with phosphate buffered saline and trypsinization. The cells were collected in a corning tube, washed with PBS solution, 1 ml of 1N NaOH solution per 1 * 1,000,000 cells / mL cell was dissolved, and the absorbance was measured at 490 nm with a microplate reader to evaluate the melanin production inhibition rate.

시험물질Test substance 실시예1Example 1 실시예2Example 2 실험농도(㎍/ml)Experimental concentration (㎍ / ml) 저해효과(%)Inhibitory Effect (%) 실험농도(㎍/ml)Experimental concentration (㎍ / ml) 저해효과(%)Inhibitory Effect (%) 영양크림Nutrition Cream 100100 57.157.1 100100 64.364.3 엣센스Essence 100100 53.653.6 100100 65.665.6 마스크팩Mask Pack 100100 63.263.2 100100 74.774.7 화장비누Toilet soap 100100 52.152.1 100100 59.559.5

실험예2. 멜라닌 생성 억제효과 - 미백효과Experimental Example 2. Melanin production inhibitory effect-whitening effect

번 발명에 따른 화장료 조성물의 멜라닌 생성억제 효과를 입증하기 위하여 성인 남여 20명의 양 팔에 알루미늄 호일을 씌우고 10Cm 거리에서 자외선을 조사한다. 육안으로 색소 침착도를 판정하여 2달간 사용 전, 후 피부가 희어진 정도를 육안으로 관찰하였다.In order to demonstrate the melanin production inhibitory effect of the cosmetic composition according to the present invention, both arms of 20 adults and males are covered with aluminum foil and irradiated with ultraviolet rays at a distance of 10 cm. The degree of pigmentation was visually determined, and the degree of skin whitening before and after use for 2 months was visually observed.

실험물질Experimental substance 현저한 효과A noticeable effect 유효함Valid 효과 없음rr과kNo effect 엣업Etup 실시예1Example 1 1414 44 22 실시예2Example 2 1717 33 00 마스크팩Mask Pack 실시예1Example 1 1212 66 22 실시예2Example 2 1515 44 1One 화장비누Toilet soap 실시예1Example 1 1515 44 1One 실시예2Example 2 1717 33 00

이상에서 상세히 설명한 바와 같이 본 발명의 미백 화장료는 경옥고 및 가용 화한 경옥고로부터 미백효과가 명확히 확인되었으며, 천연물인 것을 감안하면 피부 부작용도 없는 것으로 나타났다. 이를 이용해 화장품을 만들면 미백 및 보습 화장료의 이용에 매우 큰 효과가 있다.As described in detail above, the whitening cosmetics of the present invention were clearly identified as a whitening effect from jadeite and solubilized jadeite, and it was found that there are no skin side effects in consideration of natural products. Making cosmetics using this has a very large effect on the use of whitening and moisturizing cosmetics.

Claims (2)

종래의 일반 화장품 조성물에 경옥고 추출물을 함유한 미백화장료 조성물Whitening cosmetic composition containing jadeite extract in the conventional general cosmetic composition 청구항 1에 있어서, 경옥고를 물, 친수 유기 용제 및 그 혼합물 둥 어느 하나의 용제를 섞어 추출한 가용성 경옥고를 0.01-10.0 중량%를 포함하는 경옥고 추출물을 함유한 화장품 조성물The cosmetic composition of claim 1, wherein the jadeite extract comprises 0.01-10.0% by weight of the soluble jadeite extracted by mixing water, a hydrophilic organic solvent, and a mixture of any one of them.
KR1020060029825A 2006-03-31 2006-03-31 Whithening and moisturizing cosmetics composition comprising of kyeong-ok-go KR20070098315A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009005093A1 (en) * 2007-07-02 2009-01-08 Kobayashi Pharmaceutical Co., Ltd. Skin metabolism enhancer
KR101351604B1 (en) * 2012-09-07 2014-01-15 윤하정 Manufacturing method of cosmetic composition having improved kyung-ok-go
CN103585348A (en) * 2013-11-15 2014-02-19 大连杰信生物科技有限公司 Fine jade paste preparation method and medical application thereof
KR20160119969A (en) 2015-04-07 2016-10-17 대전대학교 산학협력단 Method for preparing of Gyoungokgo and Gyoungokgo prepared therefrom
US11653099B2 (en) 2020-09-17 2023-05-16 Research & Business Foundation Sungkyunkwan University Apparatus and method with imaging reconstruction

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009005093A1 (en) * 2007-07-02 2009-01-08 Kobayashi Pharmaceutical Co., Ltd. Skin metabolism enhancer
KR101351604B1 (en) * 2012-09-07 2014-01-15 윤하정 Manufacturing method of cosmetic composition having improved kyung-ok-go
CN103585348A (en) * 2013-11-15 2014-02-19 大连杰信生物科技有限公司 Fine jade paste preparation method and medical application thereof
KR20160119969A (en) 2015-04-07 2016-10-17 대전대학교 산학협력단 Method for preparing of Gyoungokgo and Gyoungokgo prepared therefrom
US11653099B2 (en) 2020-09-17 2023-05-16 Research & Business Foundation Sungkyunkwan University Apparatus and method with imaging reconstruction

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