KR100786733B1 - Composition for improving troublesome skin comprising herb extract - Google Patents

Composition for improving troublesome skin comprising herb extract Download PDF

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KR100786733B1
KR100786733B1 KR1020060048659A KR20060048659A KR100786733B1 KR 100786733 B1 KR100786733 B1 KR 100786733B1 KR 1020060048659 A KR1020060048659 A KR 1020060048659A KR 20060048659 A KR20060048659 A KR 20060048659A KR 100786733 B1 KR100786733 B1 KR 100786733B1
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김수산
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Engineering & Computer Science (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Cosmetics (AREA)
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Abstract

본 발명은 생약 추출물을 포함하는 문제성 피부 개선용 조성물에 관한 것으로 구체적으로 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자, 진피. 검정콩, 검은깨, 누에고치 및 하수오 추출물을 포함하는 문제성 피부 개선용 조성물에 관한 것이다. 본 발명의 조성물은 생약속에 피부재생, 탄력 및 보습에 관여하는 성분과 각종 비타민 미네랄 효소, 뮤신 및 항염과 면역성분 등이 천연상태로 포함되어 있어 심각한 여드름, 아토피 개선용 화장품으로 유용하게 사용될 수 있다. The present invention relates to a composition for problem skin improvement comprising a herbal extract specifically ginseng, cheongung, three hundred seconds, Angelica, eoseongcho, licorice, peppermint, mulberry leaves, green tea, wolfberry, dermis. It relates to a problem skin improvement composition comprising black soybeans, black sesame seeds, cocoon and sewage extract. The composition of the present invention contains the components involved in skin regeneration, elasticity and moisturizing, and various vitamins and mineral enzymes, mucins and anti-inflammatory and immune components in the herbal medicine can be useful as a cosmetic for improving acne and atopic dermatitis. .

생약 추출물, 피부재생, 보습, 아토피 Herbal extract, skin regeneration, moisturizing, atopy

Description

생약 추출물을 포함하는 문제성 피부 개선용 조성물{Composition for improving troublesome skin comprising herb extract}Composition for improving troublesome skin comprising herb extract}

본 발명은 생약 추출물을 포함하는 문제성 피부 개선용 조성물에 관한 것으로 구체적으로 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자, 진피. 검정콩, 검은깨, 누에고치 및 하수오 추출물을 포함하는 문제성 피부 개선용 조성물에 관한 것이다.The present invention relates to a composition for problem skin improvement comprising a herbal extract specifically ginseng, cheongung, three hundred seconds, Angelica, eoseongcho, licorice, peppermint, mulberry leaves, green tea, wolfberry, dermis. It relates to a problem skin improvement composition comprising black soybeans, black sesame seeds, cocoon and sewage extract.

우리 몸에 있어서, 피부는 외부 환경과 직접 접해 있으면서 다양한 유해 인자로부터 우리 몸을 보호하는 기능을 담당하고 있다. 그러나 피부는 연령의 증가 또는 자외선, 외부 오염 물질 및 스트레스에 의해 점점 손상되고 이러한 요인들로부터 피부를 보호하는 기능이 약화됨으로써, 세포 보호 및 증식 능력이 떨어짐에 따라 피부 노화 현상이 촉진된다. 이러한 노화 현상은 주로 히알루론산(hyaluronic acid)의 절단과 저분자화, 섬유아세포의 콜라겐(collagen) 생성 부진 등으로 인하여 피부 각질 층 및 진피 층의 수분 보유 능력이 감소하고, 엘라스틴 (elastine) 섬유 조직의 약화에 의해 피부 탄력이 감소함으로 나타난다.In our body, the skin is in direct contact with the external environment and is responsible for protecting our body from various harmful factors. However, the skin is gradually damaged by age or ultraviolet rays, external contaminants and stress, and weakens the ability to protect the skin from these factors, thereby promoting aging of the skin as the cell protection and proliferation ability is reduced. This aging phenomenon is mainly due to the cleavage and low molecular weight of hyaluronic acid, poor collagen production of fibroblasts, and the water retention ability of the stratum corneum and dermis layer, and the elastin fiber tissue Decreased skin elasticity due to weakening.

각질층의 수분 보유능력은 건강한 피부 상태를 결정짓는 매우 중요한 인자로서 건조하고 거친 피부는 대부분 각질층의 수분 부족의 결과로 나타난다. 따라서 종래에는 각질층의 수분 보유능력을 향상시키기 위하여 보습제를 사용하여 왔으며, 주로 수용성 고분자와 다가알콜류를 그 원료로 사용하였다. 그러나, 수용성 고분자는 피부에서 건조되고 나면 얇은 피막을 형성하여 피부에 부자유함을 주고, 다가알콜류는 주변환경에서 지속적으로 수분을 취하려는 경향이 있어 끈적임이 있고 건조한 날에는 피부에 존재하는 수분을 오히려 빼앗게 되는 문제점이 있었다.Moisture retention capacity of the stratum corneum is a very important factor in determining healthy skin condition. Dry and rough skin is mostly the result of lack of moisture in the stratum corneum. Therefore, in the past, humectants have been used to improve the water retention ability of the stratum corneum, and mainly water-soluble polymers and polyhydric alcohols are used as raw materials. However, water-soluble polymers form a thin film after drying on the skin, which gives the skin inconvenientness, and polyhydric alcohols tend to take moisture in the surrounding environment, which is sticky and rather dry on the dry days. There was a problem that was taken away.

따라서, 최근에는 동물, 식물, 미생물 등으로부터 얻은 생리 활성 물질을 화장료에 도입하여 피부 자체의 고유 방어 기능을 유지시킴으로서 보습력과 탄력을 증강시키는 피부 노화 방지용 화장료의 개발이 활발해지고 있다. 특히, 엘라스틴에 특이적으로 작용하는 엘라스타제 저해 작용을 갖는 물질이나 히알루론산을 분해하는 히알루로니다제 활성 억제 물질에 대한 연구가 계속되고 있다. 그러나, 이러한 화장료들은 대부분 그 효능이 미진하거나, 다량 또는 장기간 사용에 따른 부작용의 위험이 있으며, 고온, 일광에 대한 안정성이 떨어지는 등의 문제점을 가지고 있다. Therefore, in recent years, the development of cosmetics for preventing skin aging to enhance the moisturizing power and elasticity by introducing physiologically active substances obtained from animals, plants, microorganisms, etc. into cosmetics to maintain the inherent defense function of the skin itself. In particular, studies on substances having an elastase inhibitory activity specifically acting on elastin and inhibitors of hyaluronidase activity degrading hyaluronic acid continue. However, most of these cosmetics are insufficient in efficacy, there is a risk of side effects due to large or long-term use, and there are problems such as high temperature, poor stability to sunlight.

한편, 아토피 피부염은 태열(Atopic dermatitis)이라고도 하며 우리나라 국민의 약 20%가 아토피 피부염으로 고생하고 있는데 그 중에서 유아기(2세 미만)는 25%, 소아기(2∼10세)는 70%, 사춘기 및 성인(11세 이상)은 5% 가 발병하고 있는 실정이다. 아토피 피부염 발병시 환자는 주로 스테로이드의 연고로 치료받고 있으 나 , 스테로이드를 사용할 경우 피부감염증, 스테로이드 좌창, 스테로이드 피부염 등의 부작용을 가져오고 있음이 보고되어 있다.On the other hand, atopic dermatitis is also called atopic dermatitis, and about 20% of Koreans suffer from atopic dermatitis. Among them, 25% in infancy (under 2 years), 70% in childhood (2-10 years), puberty and 5% of adults (11 years of age or older) develop. Patients who are treated with atopic dermatitis are mainly treated with steroid ointment, but it has been reported that steroid use has side effects such as skin infection, steroid acne and steroid dermatitis.

이에 본 발명자들은 피부 개선용 생약 추출물에 대해 연구하던 중, 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자, 진피. 검정콩, 검은깨, 누에고치 및 하수오 추출물이 피부 보습 및 탄력 증강에 효과가 있음은 물론, 뮤신에 의한 각질제거 및 항염과 면역성분에 의한 여드름, 아토피에 효과가 있음을 확인하고 이를 도입한 문제성 피부 개선용 조성물을 개발함으로써 본 발명을 완성하였다.The inventors of the present invention while researching the herbal extracts for skin improvement, ginseng, cheongung, three hundred seconds, Angelica, eoseongcho, licorice, mint, mulberry leaves, green tea, gojija, dermis. Black soybean, black sesame, cocoon and sewage extracts are effective in moisturizing and enhancing elasticity of skin, as well as exfoliating by mucin, and effective in acne and atopy by anti-inflammatory and immune components. The present invention was completed by developing a composition for improvement.

본 발명의 목적은 여드름, 아토피 등 각종 문제성 피부 개선에 효과가 있는 10가지 이상의 생약추출물을 포함하는 화장료 조성물을 제공하는 것이다.An object of the present invention is to provide a cosmetic composition comprising more than 10 herbal extracts that are effective in improving various problematic skin such as acne, atopy.

본 발명은 문제성 피부 개선 효과가 있는 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자, 진피, 검정콩, 검은깨, 누에고치 및 하수오의 혼합 생약 추출물을 제공한다.The present invention provides a mixed herbal extract of ginseng, cheongung, three hundreds, Angelica, eoseongcho, licorice, peppermint, mulberry leaves, green tea, wolfberry, dermis, black beans, black sesame seeds, cocoon and sewage having a problem skin improvement effect.

또한, 본 발명은 상기 추출물을 유효성분으로 함유하는 화장료 조성물을 제공한다.The present invention also provides a cosmetic composition containing the extract as an active ingredient.

이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 본 발명은 문제성 피부 개선 효과가 있는 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자, 진피. 검정콩, 검은깨, 누에고치 및 하수오의 혼합 생약 추출물을 제공한다. The present invention is a ginseng, Cheongung, three hundred seconds, Angelica, Eungchocho, licorice, mint, mulberry leaves, green tea, wolfberry, dermis having a problem skin improvement effect. Provided are mixed herbal extracts of black beans, black sesame seeds, cocoons and sewage.

본 발명의 추출물은 건조 중량으로 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자 및 진피 각각 1 내지 6 중량부. 검은깨 1 내지 8 중량부, 누에고치 1 내지 10 중량부 및 하수오 1 내지 6 중량부를 포함하고 바람직하게는 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자 및 진피 각각 4 중량부, 검정콩 5 중량부, 검은깨 5 중량부, 누에고치 8 중량부 및 하수오 4 중량부를 포함한다.Extract of the present invention is dry weight of ginseng, Cheongung, three hundred seconds, Angelica, eoseongcho, licorice, mint, mulberry leaves, green tea, wolfberry and dermis 1 to 6 parts by weight, respectively. 1 to 8 parts by weight of black sesame seeds, 1 to 10 parts by weight of cocoon, and 1 to 6 parts by weight of sewage, preferably ginseng, cheongung, three hundred seconds, Angelica, eoseongcho, licorice, peppermint, mulberry leaf, green tea, wolfberry and dermis 4 By weight, black beans 5 parts by weight, black sesame seeds 5 parts by weight, cocoon 8 parts by weight and sewage 4 parts by weight.

본 발명자들은 물에 인삼, 구기자, 진피, 뽕잎. 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 녹차, 누에고치 및 하수오를 넣고 가마솥에 은근한 불로 중탕시켜 1차 용액을 제조하였다. 1차 용액을 다시 대류진공저온 추출법으로 증류하여 2차 용액을 수득하였다. 대류란 유체가 물질 자신이 운동에 의해 열을 전달하는 현상으로, 이로 인하여 약재와 함게 투입된 물이 고루 섞이게 되고 순환식 대류 방식으로 추출되는 생약은 용출과 대류를 통하여 일부 독성이 제거되고 생약의 고유성분만 추출되는 제조공정으로 시간이 오래 걸리고 까다로운 추출법이다. 상기 제조공정으로 추출된 용액은 1차 추출에서는 검고 진한 갈색빛을 띄나 대류진공저온으로 추출된 2차 용액은 맑고 투명한 성상을 나타내었다.The present inventors ginseng, wolfberry, dermis, mulberry leaves in water. Cheonggung, three hundred seconds, Angelica, Eungseongcho, licorice, peppermint, green tea, cocoon and sewage were put into a cauldron and heated in a warm fire to prepare a primary solution. The primary solution was again distilled by convective vacuum extraction to obtain a secondary solution. Convection is a phenomenon in which a fluid transfers heat by the movement of a substance itself, which causes water mixed with medicine to be evenly mixed, and herbal medicines extracted by a circulating convection method remove some toxicity through elution and convection, and the uniqueness of herbal medicines. It is a manufacturing process that only extracts minutes and takes a long time and is difficult to extract. The solution extracted by the manufacturing process showed a dark and dark brown color in the first extraction, but the secondary solution extracted with the convective vacuum low temperature showed clear and transparent properties.

상기 추출 용매로는 물 뿐 아니라, 알코올 또는 물과 알코올의 혼합물을 사용할 수 있다. As the extraction solvent, not only water, but also alcohol or a mixture of water and alcohol may be used.

또한, 본 발명은 상기 추출물을 유효성분으로 함유하는 화장료 조성물을 제공한다.The present invention also provides a cosmetic composition containing the extract as an active ingredient.

본 발명자들은 상기 혼합 추출물의 함량을 달리하여 화장료 조성물을 제조한 후, 조성물을 실험대상에 도포하였을 때의 수분 보유능, 피부 탄력 증강 효과 및 아토피성 피부염 치료효과를 알아보았다.The present inventors prepared a cosmetic composition by varying the content of the mixed extract, and then examined the water retention ability, skin elasticity enhancing effect and atopic dermatitis treatment effect when the composition was applied to the test subject.

그 결과, 조성물 내의 추출물 함량이 늘어날수록 피실험자의 피부 수분 함량(표 1 참조), 피부 탄력 개선도(표 2 참조) 및 아토피성 피부염 증상(표 3 참조)이 호전됨을 확인하였다. 따라서, 본 발명의 추출물을 포함하는 조성물은 문제성 피부 개선에 유용하게 사용될 수 있다.As a result, it was confirmed that the skin moisture content (see Table 1), skin elasticity improvement (see Table 2), and atopic dermatitis symptoms (see Table 3) of the subject improved as the extract content in the composition increased. Therefore, the composition containing the extract of the present invention can be usefully used to improve problem skin.

본 발명의 화장료 조성물에서 상기 혼합 생약 추출물은 화장료 조성물 총 중량에 대하여 1 내지 30 중량 % 함유될 수 있으며, 바람직하게는 20 중량 %가 함유될 수 있다. In the cosmetic composition of the present invention, the mixed herbal extract may be contained in an amount of 1 to 30% by weight, and preferably 20% by weight, based on the total weight of the cosmetic composition.

본 발명의 화장료 조성물은 그 제형에 있어서 특별히 한정되는 바가 없으며, 예를 들어 유연 화장수, 수렴 화장수, 영양 화장수, 영양 로션, 아이크림, 영양크림, 마사지 크림 클렌징 크림 클렌징폼, 클렌징워터, 엣센스, 팩 등 피부 외용제로 제조될 수 있다. 또한, 본 발명의 화장료 조성물은 화장료의 제형 또는 사용 목적에 따라 상기 혼합 생약 추출물 이외에 해당 기술 분야에서 통상적으로 사용되는 1 종 이상의 다른 성분을 포함할 수 있다.The cosmetic composition of the present invention is not particularly limited in the formulation, for example, flexible lotion, astringent lotion, nutrition lotion, nutrition lotion, eye cream, nutrition cream, massage cream cleansing cream cleansing foam, cleansing water, essence, pack It may be prepared as an external skin preparation. In addition, the cosmetic composition of the present invention may include one or more other components conventionally used in the art in addition to the mixed herbal extract according to the formulation or purpose of use of the cosmetic.

이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐 본 발명을 한정하지는 않는다.Hereinafter, the present invention will be described in detail by way of examples. However, the following Examples are only for illustrating the present invention and do not limit the present invention.

<실시예 1> 생약 추출물 및 화장료 조성물 제조Example 1 Preparation of herbal extract and cosmetic composition

1) 생약 추출물1) herbal extract

물 100kg에 인삼, 구기자, 진피, 뽕잎. 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 녹차의 재료를 각각 4kg 씩 넣고 검정콩,검정깨는 각각 5kg씩 넣고 누에고치는 8kg, 하수오(이상 경동시장)는 4kg를 넣고가마솥에 은근한 불로 24시간 중탕식으로 용액이 대략 50kg 내지 80kg이 되도록 1차 용액을 제조하였다. 1차 용액을 다시 대류진공저온 추출법으로 추출하여 용액이 40 내지 50kg이 남도록 증류한 생약을 2차로 추출하였다. 구체적으로 압력솥에 1차로 추출된 용액의 1/2을 넣고 압을 채운 후 솥의 기능관에 구리관을 연결하여 외부공기가 유입되지 않도록 밀가루 반죽으로 작은틈새까지도 막아주었다. 상기 구리관을 흐르는 수돗물에 연결하여 용액이 솥에서 가열되기 시작하면 온도를 낮추어 순환 냉각시켜 한방울 한방울 증류된 순도 높은 용액을 수득하였다. 상기 제조공정으로 추출된 용액은 1차 추출에서는 검고 진한 갈색빛을 띄나 대류진공저온으로 추출된 2차 용액은 맑고 투명한 성상을 띈다. Ginseng, wolfberry, dermis and mulberry leaves in 100 kg of water. 4kg each of Cheonggung, three hundreds, Angelica, Echo, Licorice, Mint and Green Tea, 5kg each of black beans and black sesame seeds. The primary solution was prepared such that the solution was approximately 50 kg to 80 kg. The primary solution was again extracted by convective vacuum extraction to extract the crude drug distilled so that the solution remained 40-50 kg. Specifically, 1/2 of the solution extracted primarily in a pressure cooker was filled with pressure, and then a copper gap was blocked with a flour dough to prevent external air from entering by connecting a copper pipe to a function pipe of the cooker. The copper tube was connected to the flowing tap water, and when the solution started to be heated in the pot, the temperature was lowered and circulated to cool to obtain a high-purity solution distilled drop by drop. The solution extracted by the manufacturing process has a dark brown color in the first extraction, but the secondary solution extracted with the convective vacuum low temperature has a clear and transparent appearance.

2) 화장료 조성물 제조2) Cosmetic composition preparation

실시예 1의 추출물 10 중량%를 넣고 통상의 방법으로 영양로션을 제조하였다.10 wt% of the extract of Example 1 was added to prepare a nutrition lotion in a conventional manner.

<실시예 2 내지 5> 화장료 조성물 제조<Examples 2 to 5> Preparation of the cosmetic composition

실시예 2 내지 5의 추출물을 각각 15, 20, 25, 30 중량% 씩 넣고 통상의 방법으로 영양로션을 제조하였다.15, 20, 25, 30 wt% of the extracts of Examples 2 to 5 were added, respectively, to prepare a nutrition lotion in a conventional manner.

<실험예 1> 수분 보유능 측정Experimental Example 1 Measurement of Water Retention Capacity

20세에서 50세의 연령대로 구성된 30명의 여성을 피실험자로 하였다. 22℃, 상대습도 47 % 의 항온 항습실에서 실시예 1 내지 5 및 비교예에서 제조한 각 조성물을 얼굴에 일정량(0.05g/20㎠)을 도포하고, 도포 전, 도포 1시간 후, 도포 2시간 후의 피부 수분 함량을 수분 함량 측정기 (Corneometer CM820 Courage-Khazaka, Koln, Germany)를 사용하여 측정하였다. Thirty women, ages 20 to 50, were included. A constant amount (0.05 g / 20 cm 2) was applied to the face of each of the compositions prepared in Examples 1 to 5 and Comparative Example at a constant temperature and humidity room of 22 ° C. and a relative humidity of 47%, before application, 1 hour after application, and then 2 hours of application. Post skin moisture content was measured using a moisture content meter (Corneometer CM820 Courage-Khazaka, Koln, Germany).

[표 1] TABLE 1

실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예Comparative example 도포 전Before application 5050 5050 5050 5050 5050 5050 도포 1시간 후1 hour after application 8282 8383 8585 9090 8989 7373 도포 2시간 후2 hours after application 6868 7070 7171 7373 7272 6363

(단위: μS/cm)(Unit: μS / cm)

표 1에 나타난 바와 같이, 본 발명의 조성물은 함량이 증가할수록, 피실험자의 피부 수분 함량도 증가되었다.As shown in Table 1, as the composition of the present invention increased in content, the skin moisture content of the test subject also increased.

<실험예 2> 피부 탄력 증강 효과Experimental Example 2 Skin Elasticity Enhancer Effect

20 세에서 50 세의 연령대로 구성된 30 명의 여성을 피실험자로 하였다. 22 ℃, 상대습도 47 %의 항온항습실에서 실시예 1 내지 5 및 비교예에서 제조한 각 조성물을 피실험자의 눈가에 일정량(0.05 g/20㎠)을 8 주 동안 도포하였다. 이때, 피실험자를 A, B, C, D, E군의 5개 군으로 나누어 A군의 눈가의 왼쪽에는 비교예, 눈가의 오른쪽에는 실시예 1 의 추출물을 도포하고 나머지 군도 같은 방법으로 한쪽에는 비교예 그리고 실시예 2, 3, 4, 5를 각각 도포하였다. 그 후, 피부 탄력 측정기(Cutometer SEM 575, C+K Electronic Co., Germany)를 이용하여 각 군의 피부 탄력을 측정하였다.Thirty women, ages 20 to 50, were included. Each composition prepared in Examples 1 to 5 and Comparative Example was applied at a constant temperature and humidity of 22 ° C. and a relative humidity of 47% at the eye of the subject for a certain amount (0.05 g / 20 cm 2) for 8 weeks. At this time, the test subjects were divided into five groups of A, B, C, D, and E groups, and the extract of Example 1 was applied to the left side of group A, and the extract of Example 1 was applied to the right side of the eye, and the other groups were compared on one side in the same manner. Examples and Examples 2, 3, 4 and 5 were applied respectively. Thereafter, skin elasticity of each group was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany).

[표 2]TABLE 2

실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예Comparative example 피부탄력개선도(%)Skin elasticity improvement (%) 3434 3737 4141 5050 4949 2222

표 2에 나타난 바와 같이, 본 발명의 추출물은 함량이 증가할수록 피실험자의 피부 탄력 개선도가 증가되었다. 따라서 본 발명의 추출물은 피부 탄력 증강 효과가 우수함을 알 수 있다.As shown in Table 2, the extract of the present invention increased the skin elasticity of the test subject as the content increased. Therefore, the extract of the present invention can be seen that the skin elasticity enhancing effect is excellent.

<실험예 3> 생약 추출물의 아토피성 피부염 치료효과 확인<Experiment 3> Confirmation of atopic dermatitis treatment effect of herbal extract

아토피성 피부염 증상을 나타내는 성인 및 어린이 30명을 대상으로 아토피성 피부염 발병부위에 상기 실시예 1에서 제조한 본 발명의 추출물을 1일 2회씩 2 주 동안 도포하였다. 2 주 후에 육안으로 치료효과를 판단한 결과, 표 2에 나타난 바와 같이 30명 중 21명의 아토피성 피부염 증상이 매우 호전되었거나 호전되었다. 부작용도 전혀 없었다.Thirty adults and children showing atopic dermatitis symptoms were applied to the atopic dermatitis onset site for two weeks, twice a day, for the extract of the present invention prepared in Example 1. As a result of visual evaluation of the therapeutic effect after 2 weeks, as shown in Table 2, 21 of 30 patients showed improvement or improvement of symptoms of atopic dermatitis. There were no side effects.

[표 3] 아토피성 피부염 치료효과[Table 3] Atopic Dermatitis Treatment Effect

실험대상 치료효과Subject's treatment effect 성인(10)Adult (10) 어린이(20)Child (20) 매우 호전Very good 33 99 호전Improvement 66 77 변화없음No change 1One 44 악화worse 00 00

<제제예><Example

성분명Ingredient Name 용량(%)Volume(%) 혼합생약추출물 Mixed Herbal Extract 67.20 67.20 부틸렌글라이콜 Butylene Glycol 8.00 8.00 트리이소옥타노인 Triisooctanoin 5.00 5.00 스쿠알란(식물성) Squalane (vegetable) 3.00 3.00 마카다미아넛오일 Macadamia Nut Oil 2.00 2.00 시메치콘 Shimechikon 2.00 2.00 히아루론산소다 Hyaluronic Acid Soda 2.00 2.00 콜라겐 Collagen 2.00 2.00 엘라스틴 Elastin 2.00 2.00 소르비탄 모노올레이트  Sorbitan monooleate 1.00 1.00 폴리솔베이트80  Polysorbate 80 1.00 1.00 글리세릴모노스테아레이트 Glyceryl Monostearate 1.00 1.00 세틸알코올 Cetyl alcohol 1.00 1.00 스테아릴알코올 Stearyl alcohol 1.00 1.00 트레할로스 Trehalose 1.00 1.00 디메치콘 Dimethicone 0.50 0.50 초산토코페롤 Tocopherol Acetate 0.10 0.10 잔탄검 Xanthan Gum 0.10 0.10 알란토인  Allantoin 0.10 0.10 합계 Sum 100.00 100.00

본 발명의 피부 개선용 조성물은 10가지 이상의 생약추출물을 포함하며, 피부재생 효과가 있는 알란토인 탄력및 보습에 관여하는 콜라겐과 엘라스틴, 피부에 영양을 공급하고 피부톤을 맑게 해주는 단백질과 각종 비타민 미네랄 효소, 각질제거 작용을 하는 뮤신성분이 모두 천연상태로 포함되어 있다. 그리고 생약자체의 성분에 항염과 면역성분이 함유되어 있어 여드름, 아토피에 탁월한 효과가 있어 다양한 문제성 피부 및 박피나 레이저 수술 후에도 피부 개선을 위한 화장품 원료로 유용하게 사용될 수 있다.Skin improvement composition of the present invention comprises more than 10 herbal extracts, allantoin has a skin regeneration effect collagen and elastin involved in elasticity and moisturizing, protein and various vitamins mineral enzymes to nourish skin and clear skin tone, All of the mucin ingredients that exfoliate work are included in natural state. In addition, since the anti-inflammatory and immune components are contained in the ingredients of the herbal medicine itself, it has an excellent effect on acne and atopy, and thus can be usefully used as a cosmetic raw material for improving skin even after various problem skin and peeling or laser surgery.

Claims (7)

인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자 및 진피 각각 1 내지 6 중량부, 검정콩 및 검은깨 각각 1 내지 8 중량부, 누에고치 1 내지 10 중량부 및 하수오 1 내지 6 중량부로 이루어진 혼합 생약에서 추출된 추출물을 유효성분으로 함유하며, 아토피성 피부 및 건조 또는 노화, 박피 시술 후 또는 레이저 시술 후의 피부로 구성된 군으로부터 선택되는 문제성 피부의 개선용 조성물.1 to 6 parts by weight of ginseng, cheongung, three hundred seconds, Angelica, eoseongcho, licorice, peppermint, mulberry leaf, green tea, wolfberry and dermis, 1 to 8 parts by weight of black beans and black sesame seeds, 1 to 8 parts by weight of cocoon, and 1 to 10 parts by weight of cocoon A composition for improving problem skin containing an extract extracted from a mixed herbal medicine consisting of 6 parts by weight as an active ingredient and selected from the group consisting of atopic skin and skin after drying or aging, dermabrasion or laser treatment. 제 1항에 있어서, 추출은 물, C1 내지 C3 저급알코올 또는 이의 혼합물에 의한 것임을 특징으로 하는 조성물.The composition of claim 1 wherein the extraction is by water, C 1 to C 3 lower alcohols or mixtures thereof. 삭제delete 삭제delete 제 1항에 있어서, 인삼, 천궁, 삼백초, 당귀, 어성초, 감초, 박하, 뽕잎, 녹차, 구기자 및 진피 각각 4 중량부, 검정콩 5 중량부, 검은깨 5 중량부, 누에고치 8 중량부 및 하수오 4 중량부인 것을 특징으로 하는 조성물.According to claim 1, Ginseng, Cheongung, three hundred seconds, Angelica, Eungseongcho, licorice, peppermint, mulberry leaf, green tea, wolfberry and dermis 4 parts by weight, black beans 5 parts by weight, black sesame 5 parts, cocoon 8 parts by weight and sewage 4 parts by weight of the composition. 삭제delete 제 1항에 있어서, 추출물을 1 내지 30 중량% 함유하는 것을 특징으로 하는 조성물.The composition of claim 1, which contains 1 to 30% by weight of the extract.
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