KR102031052B1 - Moisturizing composition comprising Panax ginseng polysaccharide and Green tea polysaccharide - Google Patents

Abstract

The present invention relates to a moisturizing composition, and more particularly, to a composition having excellent effects of restoring damaged skin barrier function and increasing skin moisturizing power by containing ginseng polysaccharide and green tea polysaccharide as active ingredients.

Description

Moisturizing composition comprising Panax ginseng polysaccharide and Green tea polysaccharide}

The present invention relates to a moisturizing composition, and more particularly, to a composition having excellent effects of restoring damaged skin barrier function and increasing skin moisturizing power by containing ginseng polysaccharide and green tea polysaccharide as active ingredients.

In the human body, the skin acts as a protective film to protect the living body from the external environment. It prevents the loss of biological components such as water or electrolytes and prevents harmful substances from entering the body. . The skin is largely divided into epidermal layer, dermis layer and subcutaneous fat layer, and the epidermal layer is composed of keratinocytes and melanocytes. In particular, the stratum corneum (horney layer) in the outermost part of the skin is in direct contact with the external environment, which requires strong resistance to physical, chemical, or permeation of substances, and prevents the loss of moisture from the human body to the outside. At the same time, it should maintain flexibility by retaining adequate moisture on its own. This protective function can be maintained only if the stratum corneum consisting of keratinocytes is normally formed.

Keratinocytes are characteristic cells whose basal cells, which continuously proliferate in the epidermal layer, undergo morphological and functional changes in stages and rise to the skin surface. After a period of time, the old keratinocytes are removed from the skin and the new keratinocytes take over. This repetitive process of change is called "epidermal differentiation" or "keratinization." In addition, during keratinization, keratinocytes form a natural moisturizing factor (NMF) and intercellular fats (ceramides, cholesterol, fatty acids), forming a stratum corneum, which makes the stratum corneum firm and flexible, thus creating a skin barrier. function as a barrier.

However, in recent years, the risk factors for the skin are gradually increasing, the formation and dropping rate of the stratum corneum is slowed down according to the dietary changes, and the amount of natural moisturizing factors and lipids is reduced due to the deterioration of the function of keratinocytes. Increasingly, the cases that do not exhibit. This disruption of skin barrier function leads to various skin diseases such as dry skin, atopic dermatitis, contact dermatitis and psoriasis.

Therefore, various studies have been conducted to supply moisture from the outside or prevent moisture loss from the body in order to maintain proper skin moisture, and various moisturizers having water retention capabilities have been developed. As skin moisturizers, it is common to use lipid components such as ceramides and substances that can increase water retention in the stratum corneum such as essential fatty acids and lipid complexes (Rawlings AV et al, J. Invest . Dermatol. , 5, pp731- 741, 1994).

Therefore, the inventors of the present invention, when using a ginseng polysaccharide derived from ginseng and a green tea polysaccharide derived from green tea at the same time, compared to the case of using each of these ingredients by a synergistic effect to effectively restore the damaged skin barrier function and effectively increase the amount of skin moisturizing The present invention was completed.

Accordingly, an object of the present invention is to provide a composition that provides an excellent skin moisturizing effect by simultaneously using ginseng polysaccharide and green tea polysaccharide.

In order to achieve the above object, the present invention provides a moisturizing skin external composition or pharmaceutical composition containing ginseng polysaccharide and green tea polysaccharide as an active ingredient.

The composition of the present invention exhibits the effect of increasing the skin moisturizing and recovery of impaired skin barrier function by containing ginseng polysaccharide and green tea polysaccharide. Therefore, the composition containing the ginseng polysaccharide and green tea polysaccharide is useful for preventing or improving skin dryness, atopic dermatitis, contact dermatitis or psoriasis as a composition for moisturizing skin, enhancing skin barrier function and inducing differentiation of keratinocytes. Can be used.

The composition of the present invention provides an excellent skin moisturizing effect by containing ginseng polysaccharide and green tea polysaccharide as active ingredients.

Hereinafter, the present invention will be described in more detail.

Ginseng (Panax ginseng CA Meyer) polysaccharide used in the present invention is a pectin-like substance having a molecular weight of 34,600, and galacturonic acid accounts for about 60%, and other arabinose, rhamnose, glucose and Galactose and the like constitute a side chain. Ginseng used in the present invention is a plant belonging to the genus Ogapi and ginseng, ginseng in the present invention can be used without limitation to the type and lotus root (年根), can be used both dried and undried ginseng. In addition, ginseng in the present invention can be used without limitation in the area, specifically, the root of ginseng can be used.

In addition, the green tea polysaccharide used in the present invention is derived from green tea, and unlike the polysaccharides found in other plants, it is an acidic polysaccharide group, and is produced by combining sugar components and amino acids made through photosynthesis. Green tea in the present invention can be used without limitation in the type and cultivation days, it is possible to use both dried or not dried green tea. In addition, the green tea in the present invention can be used without limitation, specifically, the leaves of green tea can be used.

Ginseng polysaccharide and green tea polysaccharide used in the present invention may be prepared by a method known in the art, the method is not particularly limited. Specifically, after preparing ginseng root or green tea leaf extract with water at 38-42 ° C., and concentrating it, removing impurities with a filter, and then adding ethanol and hot air drying, green tea polysaccharide and ginseng polysaccharide can be obtained. .

The composition of the present invention may contain a ginseng polysaccharide and a green tea polysaccharide in an amount of 0.001 to 10% by weight based on the total weight of the composition, respectively, preferably a ginseng polysaccharide and green tea polysaccharide to 0.005 to 9.5% by weight relative to the total weight of the composition, respectively. , 0.01-9%, 0.03-8.5%, 0.05-8%, 0.07-7.5%, 0.09-7%, 0.1-6.5%, 0.3-6%, 0.5-5.5% or 0.7 It may be contained in an amount of ˜5% by weight.

In the present invention, ginseng polysaccharide and green tea polysaccharide are used by mixing in the range of 0.1 to 10: 1 by weight. In addition, in order to maximize the synergistic effect of the combination of the two components, preferably used to mix the ginseng polysaccharide and green tea polysaccharide in the range of 0.5 to 9.5: 1, 1 to 9: 1 or 1.5 to 8.5: 1 by weight ratio Can be.

The moisturizing composition according to the present invention can be used for enhancing skin barrier function and inducing differentiation of keratinocytes of the skin, thereby preventing or improving skin dryness, atopic dermatitis, contact dermatitis or psoriasis, etc., caused by incomplete epidermal differentiation. It can be usefully used as a topical skin composition.

The composition of the present invention may be formulated as an external composition for skin, in particular a cosmetic composition, and may be formulated containing a cosmetically or dermatologically acceptable medium or base. In addition, the compositions of the present invention may be provided in all formulations suitable for topical application, for example, emulsions obtained by dispersing an oil phase in a solution, an aqueous phase, emulsions obtained by dispersing an aqueous phase in an oil phase, suspensions, solids, gels, powders, It may be provided in the form of a paste, foam or aerosol composition. Compositions of such formulations may be prepared according to conventional methods in the art.

In addition, the composition according to the present invention may include other ingredients in addition to the above-mentioned materials within a range not impairing the main effect, preferably a synergistic effect on the main effect. In addition, the composition according to the present invention may further include a moisturizer, an emulsifier, a UV absorber, a preservative, a fungicide, an antioxidant, a pH adjuster, organic and inorganic pigments, flavoring, cooling agent or limiting agent. The blending amount of the above components can be easily selected by those skilled in the art within the range that does not impair the object and effect of the present invention, the blending amount may be 0.01 to 5% by weight, specifically 0.01 to 3% by weight relative to the total weight of the composition. .

In addition, the compositions of the present invention may be formulated as pharmaceutical compositions. When the composition according to the present invention is applied to a pharmaceutical product, it may be formulated as an oral or parenteral dosage form in the form of a solid, semi-solid or liquid by adding a commercially available inorganic or organic carrier to the active ingredient used in the present invention. , The pharmaceutical composition according to the invention can be administered orally, parenteral, rectal, topical, transdermal, intravenous, intramuscular, intraperitoneal, subcutaneous.

Formulations for oral administration include tablets, pills, granules, capsules, powders, fine granules, powders, emulsions, syrups, pellets and the like. In addition, the formulation for parenteral administration includes injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like. The composition according to the present invention can be easily formulated by carrying out according to a conventional method, and at this time, surfactants, excipients, coloring agents, spices, preservatives, stabilizers, buffers, suspending agents, and other commercially available auxiliaries can be suitably used. have.

The dosage of the active ingredient of the pharmaceutical composition of the present invention will vary depending on the age, sex, weight, pathology and severity of the subject to be administered, the route of administration or the judgment of the prescriber. Determination of a suitable dose based on these factors is within the level of one skilled in the art, the daily dosage of which is for example 0.1 mg / kg / day to 100 mg / kg / day, more specifically 5 mg / kg / day to 50 mg / kg May be, but is not limited to.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention, and it will be apparent to those skilled in the art that the scope of the present invention is not to be construed as being limited by these examples.

Comparative Example 1 Preparation of Ginseng Polysaccharide

1 kg of dried white ginseng was pulverized with a blender, and 10 liters of purified water was added thereto, stirred and extracted with 38-42 ° C. hot water for 24 hours, and then deposited at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to 1/10 the amount of purified water. To this was added dropwise ethanol in a concentrated amount of 4 times and hot air dried to obtain 65 g of ginseng polysaccharide.

Comparative Example 2 Preparation of Green Tea Polysaccharide

1 kg of the first processed green tea leaves were pulverized with a blender, and then 10 liters of purified water was added thereto, stirred and extracted with hot water at 38-42 ° C. for 24 hours, and then deposited at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to 1/10 the amount of purified water. To this was added dropwise four times the concentrated ethanol and hot air dried to obtain 72g of green tea polysaccharide.

Example 1 Preparation of a Mixture of Ginseng Polysaccharide and Green Tea Polysaccharide

The ginseng polysaccharide prepared in Comparative Example 1 and the green tea polysaccharide prepared in Comparative Example 2 were mixed in a weight ratio of 1: 3.

Example 2 Preparation of Mixture of Ginseng Polysaccharide and Green Tea Polysaccharide

The ginseng polysaccharide prepared in Comparative Example 1 and the green tea polysaccharide prepared in Comparative Example 2 were mixed in a weight ratio of 1: 1.

Example 3 Preparation of Mixture of Ginseng Polysaccharide and Green Tea Polysaccharide

The ginseng polysaccharide prepared in Comparative Example 1 and the green tea polysaccharide prepared in Comparative Example 2 were mixed in a weight ratio of 3: 1.

Test Example 1 Measurement of Keratinocyte Differentiation Promotion Effect

In order to confirm the skin barrier function and skin moisturizing ability of Examples 1 to 3 and Comparative Examples 1 to 2, the amount of Cornified Envelop (CE) generated during the differentiation of keratinocytes was measured using absorbance.

First, primary cultured human keratinocytes (HaCaT) (obtained by Dr. NE Fusenig, Deutsches Krebsforschungszentrum, Heidelberg, Germany) were attached to the bottom of the culture flask, and then attached to the culture solution as shown in Table 1 below. In addition, the cells were cultured for 5 days until the cells grew to 70-80% of the floor area. The cells were harvested and washed with PBS (phosphate buffered saline), followed by 10 mM Tris-HCl (Tris-HCl) containing 2% Sodium Dodecyl Sulfate (SDS) and 20 mM Dithiothreitol (DTT). , pH 7.4) 1 ml was added to perform sonication for 3 minutes, and then boiled at 85 ° C. for 10 minutes. The precipitate was separated by centrifugation at 1200 rpm for 30 minutes and suspended again in 1 ml of PBS to measure absorbance at 340 nm. Separately, a portion of the solution after the sonication was taken to measure the protein content, which was used as a reference for evaluating the degree of cell differentiation. The low calcium (0.03 mM) treated group and the high calcium (1.2 mM) treated group were negative and positive controls, respectively. Table 1 shows the test results performed by adding the Comparative Examples 1 and 2 and Examples 1 to 3 at low calcium concentrations (0.03 mM) for each concentration.

Test substance density Differentiation capacity in keratinocytes (%) Negative control (low calcium solution) 0.03mM 100 Positive control (high calcium solution) 1.2mM 215 Comparative Example 1 0.05ppm 106 0.1 ppm 109 Comparative Example 2 0.05ppm 101 0.1 ppm 102 Example 1 0.05ppm 112 0.1 ppm 122 Example 2 0.05ppm 115 0.1 ppm 123 Example 3 0.05ppm 115 0.1 ppm 124

As shown in Table 1, it was confirmed that the mixed use of the ginseng polysaccharide and the green tea polysaccharide of Examples 1 to 3 was excellent in promoting the differentiation of keratinocytes. Therefore, the composition of the present invention was confirmed to have a stronger skin barrier function and skin moisture protection.

Test Example 2 Measurement of Filaggrin Expression by RT-PCR Analysis

In order to test the skin moisturizing ability of the said Examples 1-3 and Comparative Examples 1-2, filaggrin expression grade was measured.

The cell line used in the experiment was run by Dr. As a Haman kerationocyte HaCaT cell line distributed from Fusenig, the cells were dispensed into 1 × 10 ⁵ cells in a 60 mm dish and incubated for 1 day, and then the test substance was treated as shown in Table 2 and then incubated for 24 hours. . Total RNA was extracted from the cells cultured and tested by the above method using Trizol (Trizol, Gibco Laboratories, USA), and then the method provided by the One Step RNA PCR Kit (AMV) (Takara Bio Inc., Japan). RT-PCR (reverse transcriptional polymerase chain reaction) analysis was performed. In this case, primers for filaggrin (Bionia, Korea) were used as primers, and expression levels were compared using beta-actin (β-actin) as an internal control. . After the image analysis, a comparison of the control group to 100 is shown in Table 2 below.

Test substance Concentration Filla Green Production (%) Untreated control - 100 Comparative Example 1 0.05ppm 110 0.1 ppm 116 Comparative Example 2 0.05ppm 115 0.1 ppm 126 Example 1 0.05ppm 120 0.1 ppm 162 Example 2 0.05ppm 118 0.1 ppm 157 Example 3 0.05ppm 116 0.1 ppm 156

As shown in Table 2, Examples 1 to 3 of the present invention was confirmed to promote the expression of filaggrin in keratinocytes, in particular to significantly promote the expression of filaggrin compared to Comparative Examples 1 and 2 Confirmed. Therefore, it can be seen that the composition of the present invention has an effect of promoting the production of the natural moisturizing factor of the skin and strengthening the skin moisturizing ability.

Test Example 3 Measurement of Skin Moisturizing Improvement

In order to measure the effects of the ginseng polysaccharide and green tea polysaccharide on the increase in skin moisturizing power, Formulation Examples 1 to 3, which are external preparations of the nutritional cream formulation, using the Comparative Examples 1 and 2 and Examples 1 to 3 3 and Comparative Formulation Examples 1 to 3 were prepared. The unit of content ratio of the following compounding component is weight%.

Ingredient Formulation Example 1 Formulation Example 2 Formulation Example 3 compare
Formulation Example 1 compare
Formulation Example 2 compare
Formulation Example 3 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Example 1 0.1 - - - - - Example 2 - 0.1 - - - - Example 3 - - 0.1 - - - Comparative Example 1 - - - 0.1 - - Comparative Example 2 - - - - 0.1 - Vegetable Cured Oil 1.50 1.50 1.50 1.50 1.50 1.50 Stearic acid 0.60 0.60 0.60 0.60 0.60 0.60 Glycerol Stearate 1.00 1.00 1.00 1.00 1.00 1.00 Stearyl alcohol 2.00 2.00 2.00 2.00 2.00 2.00 Polyglyceryl-10 Pentastearate + Behenyl Alcohol +
Sodium Stearoyl Lactylate 1.00 1.00 1.00 1.00 1.00 1.00 Arachidyl Behenyl Alcohol + Arakidylglucoside 1.00 1.00 1.00 1.00 1.00 1.00 Cetylaryl Alcohol + Cetearyl Glucoside 2.00 2.00 2.00 2.00 2.00 2.00 PEG-100 Stearate + Glycerolate + Propylene Glycol 1.50 1.50 1.50 1.50 1.50 1.50 Caprylic / Carric Triglycerides 11.00 11.00 11.00 11.00 11.00 11.00 Cyclomedicon 6.00 6.00 6.00 6.00 6.00 6.00 Preservative, incense Quantity Quantity Quantity Quantity Quantity Quantity Triethanol amine 0.1 0.1 0.1 0.1 0.1 0.1

To confirm the skin moisturizing improvement effect of Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 3 of Table 3 were evaluated as follows. Eighty healthy women in their thirties were divided into eight groups of ten, and each of the nutritional creams of Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 3 were applied to the face twice a day for 4 weeks at a temperature of 24 to 26 ° C and 75% humidity. Constant temperature and humidity conditions (24 ° C, 40% relative humidity) after the start of application, after 1 week, 2 weeks, 4 weeks after application, and after 2 weeks after the application was stopped (total 6 weeks). Skin moisture content was measured with a conniometer at. On the basis of the Koniometer value measured immediately before the start of the test, the measured value increase in each measurement was expressed as a percentage, and the results are shown in Table 4 below.

Clinical results Moisture Growth Rate (%) 1 week past 2 weeks past 4 weeks past After 6 weeks Formulation Example 1 31 39 40 28 Formulation Example 2 32 39 40 28 Formulation Example 3 31 38 39 27 Comparative Formulation Example 1 30 32 32 18 Comparative Formulation Example 2 30 33 34 21 Comparative Formulation Example 3 28 30 29 12

As shown in Table 4, Formulation Examples 1 to 3 containing the ginseng polysaccharide and green tea polysaccharide of the present invention was found to have a significantly increased skin moisture retention than the group to which Comparative Formulas 1-3 were applied. In addition, the value after 6 weeks, which is 2 weeks after the application of the test substance was stopped, was similar to the value after 1 week to 2 weeks after the test substance was applied. It was confirmed that the moisture retention of the skin is maintained for a certain period of time. Therefore, the composition of the present invention was found to enhance the skin moisturizing ability.

From the above results, it was confirmed that the ginseng polysaccharide and the green tea polysaccharide have excellent effects in promoting differentiation of keratinocytes, repairing damaged skin barriers, and increasing skin moisturizing power.

Hereinafter, the formulation example of the composition according to the present invention, but the pharmaceutical composition and cosmetic composition is applicable to various formulations, which is intended to explain in detail only, not intended to limit the present invention.

Preparation Example 1 Soft Capsule

150 mg of ginseng polysaccharide of Comparative Example 1, 150 mg of green tea polysaccharide of Comparative Example 2, 2 mg of palm oil, 8 mg of palm hardened oil, 4 mg of sulfur wax and 6 mg of lecithin were mixed and 400 mg per capsule was prepared according to a conventional method to prepare a soft capsule.

Preparation Example 2 Tablet

150 mg of ginseng polysaccharide of Comparative Example 1, 150 mg of green tea polysaccharide of Comparative Example 2, 100 mg of glucose, 50 mg of red ginseng extract, 96 mg of starch and 4 mg of magnesium stearate, 40 mg of 30% ethanol were added to form granules, and then dried at 60 ° C. It was compressed into tablets using a tableting machine.

Preparation Example 3 Granule

150 mg of ginseng polysaccharide of Comparative Example 1, 150 mg of green tea polysaccharide of Comparative Example 2, 100 mg of glucose, 50 mg of red ginseng extract and 600 mg of starch were mixed and 100 mg of 30% ethanol was added to form granules, followed by drying at 60 ° C to form granules. The next gun was filled. The final weight of the content was 1 g.

[Example 4] Softening Cosmetic (Skin Lotion)

According to the composition described in Table 5 was prepared in the conventional method for the flexible cosmetics.

Compounding ingredient Content (weight%) Ginseng Polysaccharide of Comparative Example 1 0.1 Green Tea Polysaccharide of Comparative Example 2 0.1 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, flavoring Quantity Purified water Remaining amount

[Example 5] Nutritional Longevity (Milk Lotion)

Nutritional longevity was prepared according to the conventional composition described in Table 6 below.

Compounding ingredient Content (weight%) Ginseng Polysaccharide of Comparative Example 1 0.5 Green Tea Polysaccharide of Comparative Example 2 0.5 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Beeswax 4.0 Polysorbate 60 1.5 Caprylic / Capric Triglycerides 5.0 Squalane 5.0 Sorbitassquioleate 1.5 Liquid paraffin 0.5 Cetearyl Alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, flavoring Quantity Purified water Remaining amount

Preparation Example 6 Nutrition Cream

Nutritional cream was prepared in a conventional manner according to the composition shown in Table 7.

Compounding ingredient Content (% by weight) Ginseng Polysaccharide of Comparative Example 1 1.0 Green Tea Polysaccharide of Comparative Example 2 1.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, flavoring Quantity Purified water Remaining amount

[Example 7] Massage Cream

To prepare a massage cream in a conventional manner according to the composition shown in Table 8.

Compounding ingredient Content (% by weight) Ginseng Polysaccharide of Comparative Example 1 1.5 Green Tea Polysaccharide of Comparative Example 2 1.5 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Beeswax 4.0 Cetearyl Glucoside 1.5 Sesqui oleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, flavoring Quantity Purified water Remaining amount

[Example 8] Pack

To prepare a pack in a conventional manner according to the composition described in Table 9.

Compounding ingredient Content (% by weight) Ginseng Polysaccharide of Comparative Example 1 0.1 Green Tea Polysaccharide of Comparative Example 2 0.1 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl Phenyl Ether 0.4 Polysorbate 60 1.2 Ethanol preservative 6.0 quantity Preservative, coloring, flavoring Quantity Purified water Remaining amount

[Example 9] Ointment

The ointment was prepared in a conventional manner according to the composition described in Table 10 below.

Compounding ingredient Content (% by weight) Ginseng Polysaccharide of Comparative Example 1 0.1 Green Tea Polysaccharide of Comparative Example 2 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 15.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 1.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Cetearyl Alcohol 1.0 Beeswax 4.0 Preservative, coloring, flavoring Quantity Purified water Remaining amount

As described above in detail the specific parts of the present invention, it is apparent to those skilled in the art that such specific description is merely a preferred embodiment, thereby not limiting the scope of the present invention. something to do. Thus, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

A skin moisturizing cosmetic composition containing a mixture of ginseng polysaccharide and green tea polysaccharide as an active ingredient. The cosmetic composition for moisturizing skin according to claim 1, wherein the ginseng polysaccharide and green tea polysaccharide are each contained in an amount of 0.001 to 10% by weight based on the total weight of the composition. The cosmetic composition for moisturizing skin according to claim 1, wherein the ginseng polysaccharide and green tea polysaccharide are mixed and used in a ratio of 0.1 to 10: 1 by weight. A pharmaceutical composition for preventing and improving dry skin, which contains a mixture of ginseng polysaccharide and green tea polysaccharide as an active ingredient. According to claim 4, wherein the ginseng polysaccharide and green tea polysaccharide are respectively contained in an amount of 0.001 to 10% by weight based on the total weight of the composition for preventing and improving skin dryness. The method of claim 4, wherein the ginseng polysaccharide and green tea polysaccharide are used in the ratio of 0.1 to 10: 1 by weight ratio of dry skin prevention and improvement pharmaceutical composition.