CN103585348A - Fine jade paste preparation method and medical application thereof - Google Patents

Abstract

Fresh rehmannia is juiced, ginseng and Poria are ground into fine powder, and the fine powder and rehmannia juice are mixed uniformly. Honey is added, the mixture is heated to boiling, the mixture is kept at the temperature of 80-90 DEG C for 72 hours, and thick paste is prepared and subpackaged, so that fine jade paste is obtained. Animal experiments show that the fine jade paste has an anti-anoxia effect.

Description

QIONGYUGAO preparation method and medical application thereof

Technical field

Belong to Chinese medicine preparation technology, the present invention relates to unguentum class preparation and medical usage thereof.

Background technology

Along with social senilization arrives, old people's health care industry rather society is paid close attention to, in the urgent need to developing some true medicable old people's tonification class health foods.Based on this, excavate the valuable cultural heritage of motherland, the QIONGYUGAO that wherein the < < Hong Shi collection proved recipe > > of Southern Song Dynasty's time flood Wenan records, it is a famous cream side, until today, still widely continuing to use, is the living fossil of cream side.He develops into from the prescription of a first clinical treatment cough health cream side of being liked by broad masses of the people, has wherein experienced a lot of variations and development.Its prescription is: Radix Rehmanniae, Radix Ginseng, Poria and Mel.Day this Han side System drug | this day Hai Tang Xinzhou medicine QIONGYUGAO of the Open FengJoanyu cream Tochigi of Co., Ltd., mainly as the strong agent of nourishing Strong, for inappetence, the human body fatigue, weak body Quality, sick Hou muscle power lowly, stomach Intestinal weakness, anemia, development educate the phase etc.One of pharmaceutical factory of Korea S KWANGDONG Pharmaceutical Co., Ltd ，Shi Korea S maximum.Within 1970, left and right ，KDP Co., Ltd. successfully develops QIONGYUGAO, and there is the QIONGYUGAO of selling Gindererra in Korea S at present; Its main component of QIONGYUGAO that has Shanghai Leiyun Pharmaceutical Industry Co., Ltd. to produce of domestic listing is Radix Rehmanniae, Radix Codonopsis, Poria, wherein there is no Radix Ginseng.BTV's program health preserving hall: QIONGYUGAO is self-control product.QIONGYUGAO is wide-spread both at home and abroad in a word, is subject to liking of Eastern countries people.About QIONGYUGAO oxygen lack resistant function, there is not yet report.The QIONGYUGAO that this patent utilizes Radix Rehmanniae, Radix Ginseng, Poria and Mel to make, has no side effect through zoopery proof, obviously extends the life span of mice under condition of normal pressure.

Summary of the invention

the prescription of QIONGYUGAO:

radix Rehmanniae 2000g

radix Ginseng 185g

poria 370g

mel 500g

make 1300 g

its concrete preparation method: radix Rehmanniae is squeezed to extracting juice and discards residue,people participates in that Poria is cleaned, drying and crushing is crossed 80 mesh sieves, mixes with Radix Rehmanniae juice, adds Mel, is heated to boil, and 80-90 ℃ is incubated 72 hours, makes thick paste, and packing, obtains.

good effect of the present invention is: disclose QIONGYUGAOhave no side effect, under condition of normal pressure, obviously extend the life span of mice.Improve anti-anoxia ability.

experimental example 1the impact of QIONGYUGAO on animal indices

One, experiment material

Medicine: QIONGYUGAO, before test, be made into desired concn, 4 ℃ of preservations of refrigerator, standby.Animal: 6

The Wistar in age in week is rat, and in 23 ± 1 ℃ of room temperatures, humidity 55 ± 10%, raises 1 week under 12 hours light and shade cycling conditions, for test.Between preparation feeding period, feeding solid feed, water freely absorbs.

Two, method and result

80 of rats, male and female half and half, are divided into 4 groups, and three administration groups are distinguished gavage QIONGYUGAO 18,12,6g/kg.In contrast, every day 1 time, gavage is 6 times weekly, and weighs for the 1st group of gavage equal-volume distilled water, and the administration phase is 60 days, within 24 hours after last administration, puts to death, and surveys blood, hepatic and renal function, and body weight change, the results are shown in Table 1-3.Above-mentioned every inspection, large, medium and small three dosage groups and matched group comparison, body weight, routine blood test, hepatic and renal function are without significant change.Animal is during administration, and the general signs of administration group and control animals, outward appearance, diet and movable all Non Apparent Abnormalities change.By kg body weight, calculate the suitable clinical application amount 18-54 equal non-toxic reaction of dosage doubly as seen, show that QIONGYUGAO toxicity is lower.

Table 1 QIONGYUGAO is on the impact of rat body weight (1) gX± SD

1*: QIONGYUGAO 18 g/kg, 2*: QIONGYUGAO 12 g/kg, 3*: QIONGYUGAO 6 g/kg

Table 2 QIONGYUGAO on Rat Erythrocytes, leukocyte, hemoglobin, hematoblastic impact ( x± SD)

1: matched group 2: QIONGYUGAO 18 g/kg, 3: QIONGYUGAO 12 g/kg, 4: QIONGYUGAO 6 g/kg

Table 3 qIONGYUGAOon the impact of rats'liver, renal function ( x± SD)

QIONGYUGAO 18 g/kg, 2*: QIONGYUGAO 12 g/kg, 3*: QIONGYUGAO 6 g/kg

the normal pressure oxygen lack resistant function of experimental example 2 QIONGYUGAO

The made QIONGYUGAO of experiment material embodiment 1

Laboratory animal ?60 immature Mus of ICR, male and female half and half, 23 ± 2 ℃ of receptacle temperature, humidity 50 ± 5%, mice freely ingests and drinks water, and adaptability is raised one week.

Method is got good 48 of above-mentioned adaptation, and 18-22g mice, is divided into 5 groups at random, and gastric infusion is 5 days continuously, in last administration 1h, each Mus is respectively charged in 300ml triangular flask, covers tightly bottle stopper, writing time, the results are shown in Table 4.

The normal pressure oxygen lack resistant function of table 4 QIONGYUGAO x± SD

Matched group: distilled water 20ml/kg, 1*: QIONGYUGAO 18 g/kg, 2*: QIONGYUGAO 12 g/kg, 3*: QIONGYUGAO 6 g/kg, 4*: ginseng royal jelly 20ml/kg. ^?compare P<0.05 with matched group, ^?compare P<0.02 with matched group

Illustrate that the prepared QIONGYUGAO of the present invention can improve the anti-anoxia ability of mice significantly.Strengthen adaptive capacity to environment.

The specific embodiment

embodiment 1the preparation of QIONGYUGAO

Radix Rehmanniae 2000g

Radix Ginseng 185g

Poria 370g

Mel 500g

Make 1300 g

[method for making] squeezed extracting juice by Radix Rehmanniae and discarded residue, and people participates in that Poria is cleaned, drying and crushing is crossed 80 mesh sieves, mixes with Radix Rehmanniae juice, adds Mel, is heated to boil, and 80-90 ℃ is incubated 72 hours, makes thick paste, and packing, obtains.

embodiment 2the application of QIONGYUGAO

According to the prepared QIONGYUGAO of embodiment 1, there is the effect that improves anti-anoxia ability, can be applied to that old people etc. is weak has an anoxia symptom, lip is blue, grade uncomfortable in chest can improve the ability of its anti-hypoxia, and its toxicity is low, can play anti-hypoxia auxiliary treatment and health care preventive effect.

Claims (2)

1. the preparation method of QIONGYUGAO :

[prescription] Radix Rehmanniae 2000g

radix Ginseng 185g

poria 370g

mel 500g

make 1300 g

?its concrete preparation method: Radix Rehmanniae is squeezed to extracting juice and discard residue, people participates in that Poria is cleaned, drying and crushing is crossed 80 mesh sieves, mixes with Radix Rehmanniae juice, adds Mel, is heated to boil, and 80-90 ℃ is incubated 72 hours, makes thick paste, and packing, obtains.

2. according to claim 1, gained qIONGYUGAO has oxygen lack resistant function.