CN110101597A - It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired - Google Patents
It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired Download PDFInfo
- Publication number
- CN110101597A CN110101597A CN201910566298.5A CN201910566298A CN110101597A CN 110101597 A CN110101597 A CN 110101597A CN 201910566298 A CN201910566298 A CN 201910566298A CN 110101597 A CN110101597 A CN 110101597A
- Authority
- CN
- China
- Prior art keywords
- polysaccharide
- composition
- whitening
- skin
- gumbo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 12
- 230000000254 damaging effect Effects 0.000 title description 2
- 150000004676 glycans Chemical class 0.000 claims abstract description 59
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 58
- 239000005017 polysaccharide Substances 0.000 claims abstract description 58
- 240000004507 Abelmoschus esculentus Species 0.000 claims abstract description 17
- 235000003934 Abelmoschus esculentus Nutrition 0.000 claims abstract description 17
- 241001506047 Tremella Species 0.000 claims abstract description 17
- 230000002087 whitening effect Effects 0.000 claims abstract description 16
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 15
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 14
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 14
- 229940010454 licorice Drugs 0.000 claims abstract description 14
- 230000000694 effects Effects 0.000 claims abstract description 11
- 239000002537 cosmetic Substances 0.000 claims abstract description 7
- 230000008439 repair process Effects 0.000 claims abstract description 5
- 206010013786 Dry skin Diseases 0.000 claims abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 claims abstract 2
- 208000026935 allergic disease Diseases 0.000 claims abstract 2
- 230000007815 allergy Effects 0.000 claims abstract 2
- 230000037336 dry skin Effects 0.000 claims abstract 2
- 241000133134 Saussurea Species 0.000 claims description 6
- -1 be aqua Substances 0.000 claims description 3
- 241000202807 Glycyrrhiza Species 0.000 claims 4
- 206010040829 Skin discolouration Diseases 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 description 10
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 241000700199 Cavia porcellus Species 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 238000004821 distillation Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 4
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 4
- 208000003351 Melanosis Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 3
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229960004502 levodopa Drugs 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- JDWYRSDDJVCWPB-UHFFFAOYSA-N Cyclodopa Natural products OC1=C(O)C=C2NC(C(=O)O)CC2=C1 JDWYRSDDJVCWPB-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 229930194248 Licoflavone Natural products 0.000 description 1
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241001145025 Saussurea involucrata Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- JDWYRSDDJVCWPB-LURJTMIESA-N leucodopachrome Chemical compound OC1=C(O)C=C2N[C@H](C(=O)O)CC2=C1 JDWYRSDDJVCWPB-LURJTMIESA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to cosmetic fields, provide a kind of composition and preparation method thereof with whitening and reparation skin barrier damage function.The whitening and the composition for repairing skin barrier damage function include each component of following mass percent: licorice polysaccharide 0.1%-10%, tremella polysaccharides 0.1%-10%, gumbo polysaccharide 0.1%-10%, Herba Saussureae Involueratae polysaccharide 0.1%-10%.Composition of the present invention can cause skin barrier function damage to have good repair to whitening, mitigate because of the side effects such as dry skin and allergy caused by whitening.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of group for causing skin barrier damage function with reparation whitening
Close object.
Background technique
As science and technology is increasingly developed, people's living standard is continuously improved, and whitening becomes one of the topic that people discuss warmly.It is black
Pigment is a kind of macromolecule pigment being mainly distributed in human epidermal cell and horn cell, determines the colour of skin and hair of people
Color, but when melanin accumulation is excessive, the problems such as not only causing color spot, freckle, it is also possible to tumor change occur, generate melanin
Tumor.Therefore, it is each that the drug and cosmetics research and development that can be used to prevent and treat the diseases such as pigmentation and melanoma receive the world
The extensive attention of ground scientific research personnel.
In simple terms, the synthesis of melanin passes through following procedure: by catalysis l-tyrosine hydroxyl occurs for tyrosinase
Change reaction and generate levodopa (Levodopa, L-DOPA), and further catalysis L-DOPA oxidation generates DOPA quinone
(Dopaquinone, DQ).DOPA quinone (DQ), except amino generates colourless dopachrome (cyclodopa), is ultimately produced by intramolecular
Melanin.
But while whitening, also to focus on the safety of product itself.The effect for having stronger whitening currently on the market is hydrogen
Quinone and 377 equal organic compounds can cause human skin barrier is impaired to wait side effects, no although whitening effect is obvious
Can safely and effectively whitening, have much room for improvement.
The effect of four kinds of natural plant extracts are applied in combination, can reach skin whitening by the present invention, moreover it is possible to repair damage
The skin barrier of wound, substantially increases safety and practicability.
Radix Glycyrrhizae glycyrrhizin rich in, liquorice flavonoids compound etc., there are also inhibit tyrosine enzyme activity for licoflavone
Property, remove oxygen mesh by base, oxidation resistance and vitamin E are relatively.Contain protein and a variety of amino acid, lipid, more
Carbohydrate, tartaric acid, vitamins, microelement etc., wherein protein and its hydrolysis after amino acid be used for cosmetics, have to skin
Nourishing and moisturizing effect, and have repair to the skin of damage.
Tremella natural characteristic colloid rich in, in addition its nourishing yin effect, long-term use can be with moisturizing, and dispels
The effect of face's chloasma, freckle.
Gumbo vitamin C rich in and Soluble Fiber, it is not only with health role to skin, and skin can be made beautiful
It is white, delicate；Gumbo is rich in class not radish element and beta carotene simultaneously, can protect skin, reduces radical damage.
Herba Saussureae Involueratae protein rich in, amino acid, flavone compound, alkaloid etc., can effectively adjust people
Body pH value, can accelerate the metabolism of skin, reduce wrinkle, and skin is made to keep gloss, plentiful.And to facial freckle, liver
Spot etc. has good curative effect.Containing natural snow lotus Huang cave class reed 5, saussurea involucrata lactones, its SPF of the such as Saussurea Polysaccharide is up to
Therefore 22DSE., can have and skin is protected by the infringement of ultraviolet light, not improve cutaneous pigmentation.
Summary of the invention
The purpose of the present invention is overcome nowadays cosmetics prior art deficiency, provide a kind of safe and effective and can repair skin
The composition of barrier.
To achieve the purpose of the present invention, the present invention adopts the following technical scheme:
A kind of composition with whitening and reparation damage skin barrier effect, the composition is by licorice polysaccharide, tremella polysaccharides, autumn
Certain herbaceous plants with big flowers polysaccharide, Herba Saussureae Involueratae polysaccharide mass percent be respectively the % of 0.1 % ~ 10 composition.
Preferably, the composition by licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, Herba Saussureae Involueratae polysaccharide quality percentage
Than being respectively the % of 1 % ~ 5 composition.
As most preferably, the composition by licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, Herba Saussureae Involueratae polysaccharide quality hundred
Divide than being respectively 1 % composition.
The invention has the following advantages that
(1) it screens through a large number of experiments, it is determined that the optimal proportion range of composition, it is ensured that the effect that product of the present invention uses
Fruit；
(2) inventive formulation extract is natural plants, overcomes organic matter that present most of whitening products contain to skin
Stimulation, keep this composition safer.
Specific embodiment
For a further understanding of the present invention, below in conjunction with the embodiment of the present invention, to the technical side in the embodiment of the present invention
Case is clearly and completely described, it is clear that and described embodiments are only a part of the embodiments of the present invention, rather than all
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art institute without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Unless otherwise specified, reagent involved in the embodiment of the present invention is commercial product, can pass through business canal
Road purchase obtains.The water can be deionized water, purified water or distilled water.
Embodiment 1
Medicinal material Radix Glycyrrhizae, tremella, gumbo, Herba Saussureae Involueratae are carried out to be ground into 50 mesh respectively, are added 10 times of water of quality of medicinal material, 90 DEG C
3 h are heated, are filtered；Filtrate concentration adds ethyl alcohol to generate completely to precipitating, is centrifuged, dry, extracts required for the acquisition present invention
Object.
Embodiment 2
Above-mentioned 1 g of licorice polysaccharide powder is taken, is dissolved in 99 g distillation pure water, is sufficiently stirred after dissolution to get licorice polysaccharide is contained
Aqueous solution.Wherein licorice polysaccharide concentration is 1 %.
Embodiment 3
Above-mentioned 1 g of tremella polysaccharides powder is taken, is dissolved in 99 g distillation pure water, is sufficiently stirred after dissolution to get tremella polysaccharides are contained
Aqueous solution.Wherein tremella polysaccharides concentration is 1 %.
Embodiment 4
Above-mentioned 1 g of gumbo polysaccharide powder is taken, is dissolved in 99 g distillation pure water, is sufficiently stirred after dissolution to get gumbo polysaccharide is contained
Aqueous solution.Wherein gumbo polysaccharide concentration is 1 %.
Embodiment 5
Above-mentioned 1 g of Herba Saussureae Involueratae polysaccharide powder is taken, is dissolved in 99 g distillation pure water, is sufficiently stirred after dissolution to get Tianshan Mountains is contained
The aqueous solution of Saussurea Polysaccharide.Wherein Herba Saussureae Involueratae polysaccharide concentration is 1 %.
Embodiment 6
Each 1 g of above-mentioned licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, Herba Saussureae Involueratae polysaccharide powder is taken, 96 g distillation pure water is dissolved in
In, it is sufficiently stirred after dissolution to get the aqueous solution containing licorice polysaccharide.Wherein licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, day
Mountain Saussurea Polysaccharide concentration is respectively 1 %.
Embodiment 7
1 materials and methods:
1.1 sample
2 composition of embodiment, 3 composition of embodiment, 4 composition of embodiment, 5 composition of embodiment, 6 composition of embodiment
1.2 experimental method
Zoopery
It chooses that a collection of form is normal, Female guinea pigs similar in weight, is examined by the epidemic disease of 3 d, the identical feed of feeding and water.
Blank group is set, and blank group is without any processing, normal to raise.
Model group is set, model group with UVA and UVB joint irradiation guinea pig back stripped region fluorescent tube apart from 15 cm of back,
Ultraviolet wavelength 280-320 nm, one time a day, 1 h every time.
2 groups of embodiment of setting, with UVA and UVB joint irradiation guinea pig back stripped region, fluorescent tube is purple apart from 15 cm of back
Outer wavelength 280-320 nm, one time a day.External drug since after irradiation irradiates and smears 300 μ of drug at back part shaving
L/ is only；
3 groups of embodiment of setting, with UVA and UVB joint irradiation guinea pig back stripped region, fluorescent tube is apart from 15 cm of back, ultraviolet waves
Long 280-320 nm, one time a day.External drug since after irradiation irradiates at back part shaving and smears 300 μ L/ of drug only；
4 groups of embodiment of setting, with UVA and UVB joint irradiation guinea pig back stripped region, fluorescent tube is apart from 15 cm of back, ultraviolet waves
Long 280-320 nm, one time a day.External drug since after irradiation irradiates at back part shaving and smears 300 μ L/ of drug only；
5 groups of embodiment of setting, with UVA and UVB joint irradiation guinea pig back stripped region, fluorescent tube is apart from 15 cm of back, ultraviolet waves
Long 280-320 nm, one time a day.External drug since after irradiation irradiates at back part shaving and smears 300 μ L/ of drug only；
6 groups of embodiment of setting, with UVA and UVB joint irradiation guinea pig back stripped region, fluorescent tube is apart from 15 cm of back, ultraviolet waves
Long 280-320 nm, one time a day.External drug since after irradiation irradiates at back part shaving and smears 300 μ L/ of drug only.
2 experimental results
1 cavy melanin IOD value of table
| Group | A mouse | B mouse | C mouse | Mean+SD |
| Blank | 34041 | 32804 | 38590 | 35145±3047 |
| Model | 231882 | 161903 | 158479 | 184088±41426#### |
| Radix Glycyrrhizae | 122024 | 87942 | 59264 | 89743±31419*** |
| Tremella | 96327 | 92701 | 96370 | 95133±2106*** |
| Gumbo | 51554 | 57682 | 64787 | 58008±6623**** |
| Herba Saussureae Involueratae | 86939 | 54745 | 75513 | 72399±16321**** |
| Complex polysaccharide | 38783 | 48072 | 39644 | 42167±5132**** |
Note: #### P < 0.0001 compared to the blank group；* * P < 0.001 compared with model group；* * * P < compared with model group
0.0001
From table 1, it is apparent that the melanin IOD average value of complex polysaccharide is significantly lower than other single polysaccharide groups for 42167,
And there is significant difference with model group, illustrate that composition of the present invention has white-skinned face function.
2 cavy transepidermal water loss rate of table
| Group | A mouse | B mouse | C mouse | Mean+SD |
| Blank | 15.2 | 14.1 | 9.8 | 13.0±2.9 |
| Model | 26.6 | 18.8 | 41.3 | 28.9±11.4# |
| Radix Glycyrrhizae | 22.6 | 23.2 | 23.4 | 23.1±0.4 |
| Tremella | 14.1 | 23.4 | 33.5 | 23.7±9.7 |
| Gumbo | 14.1 | 11.9 | 19.9 | 15.3±4.1 |
| Herba Saussureae Involueratae | 25.4 | 22.1 | 24.5 | 24.0±1.7 |
| Complex polysaccharide | 16.2 | 15.8 | 12.5 | 14.8±2.0 |
Note: # P < 0.05 compared to the blank group
From table 2, it is apparent that the TWEL average value of complex polysaccharide is 14.8 significantly lower than other single polysaccharides, illustrate this hair
The bright composition has protection skin barrier function.
The above, preferable specific embodiment only of the invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Design is subject to equivalent substitution or change, should be covered by the scope of protection of the present invention.
Claims (6)
1. a kind of composition with whitening and reparation skin barrier damage function, which is characterized in that more by licorice polysaccharide, tremella
Sugar, gumbo polysaccharide, Herba Saussureae Involueratae polysaccharide composition.
2. composition according to claim 1, which is characterized in that the licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, day
The mass percent of mountain Saussurea Polysaccharide is 0.1% ~ 10%.
3. composition according to claim 2, which is characterized in that the licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, day
The mass percent of mountain Saussurea Polysaccharide is 1% ~ 5%.
4. composition according to claim 3, which is characterized in that the licorice polysaccharide, tremella polysaccharides, gumbo polysaccharide, day
The mass percent of mountain Saussurea Polysaccharide is 1%.
5. composition described according to claim 1 ~ 4, which is characterized in that composition can cause skin barrier function to whitening
Damage has good repair, mitigates because of the side effects such as dry skin and allergy caused by whitening.
6. composition described according to claim 1 ~ 4, which is characterized in that can be used in skin-lightening cosmetic, be aqua, gel,
A variety of dosage forms such as mildy wash, face cream, lotion are applied in cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566298.5A CN110101597A (en) | 2019-06-27 | 2019-06-27 | It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566298.5A CN110101597A (en) | 2019-06-27 | 2019-06-27 | It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110101597A true CN110101597A (en) | 2019-08-09 |
Family
ID=67495933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910566298.5A Pending CN110101597A (en) | 2019-06-27 | 2019-06-27 | It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110101597A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190593A (en) * | 2020-10-14 | 2021-01-08 | 无限极（中国）有限公司 | Polysaccharide composition for inhibiting TRPV1 pathway and preparation method and application thereof |
| CN113397999A (en) * | 2020-03-16 | 2021-09-17 | 无限极（中国）有限公司 | Polysaccharide composition with skin barrier repairing function and application thereof |
| CN113440538A (en) * | 2020-03-25 | 2021-09-28 | 无限极（中国）有限公司 | Polysaccharide composition with effect of relieving atopic dermatitis and skin external medical auxiliary preparation |
| CN113730430A (en) * | 2021-08-23 | 2021-12-03 | 无限极（中国）有限公司 | Application of small molecular saussurea involucrate polysaccharide in adiponectin secretion regulation and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060222608A1 (en) * | 2005-04-01 | 2006-10-05 | Agricultural Research Institute | Edible tremella polysaccharide for skin care |
| CN103536455A (en) * | 2013-11-07 | 2014-01-29 | 吉林化工学院 | Application of compound bacteria polysaccharide in preparing moisture-keeping cosmetic |
| CN106361636A (en) * | 2016-09-19 | 2017-02-01 | 广东丸美生物技术股份有限公司 | Skincare composition and application thereof in skin whitening |
| CN107822948A (en) * | 2017-11-28 | 2018-03-23 | 四川省中医药科学院 | With after-sun restorative, anti-oxidant, white-skinned face function composition and preparation method thereof |
| CN109512696A (en) * | 2018-12-18 | 2019-03-26 | 海南热带海洋学院 | A kind of skin care item and preparation method thereof containing complex polysaccharide series |
-
2019
- 2019-06-27 CN CN201910566298.5A patent/CN110101597A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060222608A1 (en) * | 2005-04-01 | 2006-10-05 | Agricultural Research Institute | Edible tremella polysaccharide for skin care |
| CN103536455A (en) * | 2013-11-07 | 2014-01-29 | 吉林化工学院 | Application of compound bacteria polysaccharide in preparing moisture-keeping cosmetic |
| CN106361636A (en) * | 2016-09-19 | 2017-02-01 | 广东丸美生物技术股份有限公司 | Skincare composition and application thereof in skin whitening |
| CN107822948A (en) * | 2017-11-28 | 2018-03-23 | 四川省中医药科学院 | With after-sun restorative, anti-oxidant, white-skinned face function composition and preparation method thereof |
| CN109512696A (en) * | 2018-12-18 | 2019-03-26 | 海南热带海洋学院 | A kind of skin care item and preparation method thereof containing complex polysaccharide series |
Non-Patent Citations (1)
| Title |
|---|
| 李元文编, 辽宁科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113397999A (en) * | 2020-03-16 | 2021-09-17 | 无限极（中国）有限公司 | Polysaccharide composition with skin barrier repairing function and application thereof |
| CN113440538A (en) * | 2020-03-25 | 2021-09-28 | 无限极（中国）有限公司 | Polysaccharide composition with effect of relieving atopic dermatitis and skin external medical auxiliary preparation |
| CN112190593A (en) * | 2020-10-14 | 2021-01-08 | 无限极（中国）有限公司 | Polysaccharide composition for inhibiting TRPV1 pathway and preparation method and application thereof |
| CN113730430A (en) * | 2021-08-23 | 2021-12-03 | 无限极（中国）有限公司 | Application of small molecular saussurea involucrate polysaccharide in adiponectin secretion regulation and preparation method thereof |
| CN113730430B (en) * | 2021-08-23 | 2023-09-05 | 无限极（中国）有限公司 | Application of small molecule saussurea involucrata polysaccharide in adiponectin secretion regulation and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110101597A (en) | It is a kind of for skin-whitening and the composition of skin barrier damaging action to be repaired | |
| CN103987391B (en) | For purifying the retinene cyclodextrin acetal of the colour of skin and hemiacetal | |
| ES2614827T3 (en) | Composition containing venus flytrap extract for cosmetic treatment | |
| EP3854379A1 (en) | Cosmetic composition comprising centella asiatica adventitious root extract as effective ingredient for skin whitening and wrinkle reduction | |
| CN110312550A (en) | For by therapy treatment human body method used in, the composition comprising species ginger flowering plant extract | |
| CN111603428A (en) | Whitening and freckle-removing plant type essence, preparation method and use method | |
| CN110585048A (en) | Composition with anti-saccharification and anti-oxidation functions and application thereof | |
| KR20220112447A (en) | Composition for improving skin, comprising Elaeaqnus macrophylla Extract as effective components, Cosmetic composition and Food functional composition including the same | |
| KR20100006796A (en) | Anti-aging cosmetic composition comprising herb ferment extract | |
| KR20150074537A (en) | Cosmetic composition containing Ocimum basilicum seed extract | |
| KR102011654B1 (en) | Cosmetic composition comprising oysters, sea cucumber, sea squirt, Aplysia kurodai and buccinum striatissimum | |
| JP2006143670A (en) | Skin lotion | |
| JP5226200B2 (en) | Sulfated glycosaminoglycan production promoter and skin external preparation containing the same | |
| CN109568230A (en) | A kind of Chinese medicine cosmetic of the anti-aging of moisturizing whitening | |
| CN108852889A (en) | A kind of osmosis type beautifying face and moistering lotion cosmetics and preparation method | |
| JP3987733B2 (en) | Fibroblast activator and skin external preparation containing the same | |
| JP2009234976A (en) | Cell activator and external preparation for skin for antiaging | |
| WO2015078398A1 (en) | Chinese herbal medicine compound for repairing ultraviolet damage, and uses thereof in cosmetics | |
| KR20130062484A (en) | External composition for skin containing humulus japonicas sieboid and zucc. extract | |
| JP2004307437A (en) | Skin care preparation for external use for preventing aging | |
| KR101834153B1 (en) | Process for producing red sea cucumber-derived peptide powder and cosmetic composition for skin whitening containing the same | |
| KR20100088463A (en) | Cosmetic composition for whitening the skin comprising the extract of aronia melanocarpa as active ingredient | |
| KR20160017891A (en) | Composition for protecting skin with antioxidant activity comprising egf and placenta | |
| JP2002154920A (en) | Elongation inhibitor of dendrite of melanocyte and cosmetic comprising the same | |
| CN114344213B (en) | Skin care product and composition containing plant extracts, and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190809 |