KR20070052694A - 유전자 발현을 위한 세포-유형-특이적 패턴 - Google Patents

유전자 발현을 위한 세포-유형-특이적 패턴 Download PDF

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KR20070052694A
KR20070052694A KR1020067015965A KR20067015965A KR20070052694A KR 20070052694 A KR20070052694 A KR 20070052694A KR 1020067015965 A KR1020067015965 A KR 1020067015965A KR 20067015965 A KR20067015965 A KR 20067015965A KR 20070052694 A KR20070052694 A KR 20070052694A
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gene
cell
genes
expression
level
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Korean (ko)
Inventor
엘리자베쓰 두프 스투아트
윌리암 와치스맨
다니엘 머콜라
마이클 맥크렐랜드
제시카 왕-로드리구에즈
데이비드 트레인
찰리스 씨. 베리
카렌 아덴
린다 와서맨
스테븐 구우디슨
이고르 클라캔스키
Original Assignee
더 리젠트스 오브 더 유니이버시티 오브 캘리포니아
시드니 킴멜 캔서 센터
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Publication of KR20070052694A publication Critical patent/KR20070052694A/ko
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

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  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
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  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020067015965A 2004-01-09 2005-01-07 유전자 발현을 위한 세포-유형-특이적 패턴 Ceased KR20070052694A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53538204P 2004-01-09 2004-01-09
US60/535,382 2004-01-09
US53616304P 2004-01-12 2004-01-12
US60/536,163 2004-01-12

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KR20070052694A true KR20070052694A (ko) 2007-05-22

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Country Link
US (1) US8781750B2 (https=)
JP (2) JP2008504803A (https=)
KR (1) KR20070052694A (https=)
WO (1) WO2005068664A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025054611A1 (en) * 2023-09-08 2025-03-13 The Trustees Of Princeton University Systems and methods for predicting high resolution cell-type-specific gene transcription and applications thereof

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068664A2 (en) 2004-01-09 2005-07-28 The Regents Of The University Of California Cell-type-specific patterns of gene expression
KR20070057761A (ko) 2004-06-04 2007-06-07 아비아라디엑스, 인코포레이티드 종양의 확인방법
US20120258442A1 (en) 2011-04-09 2012-10-11 bio Theranostics, Inc. Determining tumor origin
ES2550652T3 (es) 2005-06-03 2015-11-11 Biotheranostics, Inc. Identificación de tumores y tejidos
JP2007295822A (ja) * 2006-04-28 2007-11-15 Kusakabe Bio-Medical Research Laboratory Inc 卵巣腫瘍のシスプラチン耐性マーカー
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
KR100740582B1 (ko) * 2006-09-27 2007-07-19 한국과학기술연구원 가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법
CN101932602B (zh) * 2007-06-27 2017-05-24 新加坡国立大学 用于Artemin及相关配体的多肽和多核苷酸，及其使用方法
RU2511408C2 (ru) * 2007-09-17 2014-04-10 Конинклейке Филипс Электроникс Н.В. Способ анализа нарушений, связанных с раком яичников
KR20110081338A (ko) * 2008-11-04 2011-07-13 이데라 파마슈티칼즈, 인코포레이티드 안티센스 올리고누클레오티드에 의한 ｔｏｌｌ―유사 수용체 5 발현의 조절
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
CA2745961A1 (en) * 2008-12-04 2010-06-10 The Regents Of The University Of California Materials and methods for determining diagnosis and prognosis of prostate cancer
GB0903026D0 (en) * 2009-02-23 2009-04-08 Glaxosmithkline Biolog Sa Novel method
WO2011116244A2 (en) * 2010-03-17 2011-09-22 Cedars-Sinai Medical Center Methods of diagnosing and treating conditions associated with metabolic clearance rate of insulin
US8728731B2 (en) * 2010-03-22 2014-05-20 Laboratory Corporation Of America Holdings Mutations associated with cystic fibrosis
MX338883B (es) 2010-07-27 2016-05-04 Genomic Health Inc Metodo para usar expresion de gen para determinar el pronostico de cancer de prostata.
CN103392182B (zh) 2010-08-02 2017-07-04 众有生物有限公司 用于发现遗传疾病中致病突变的系统和方法
JP2014509189A (ja) 2011-01-25 2014-04-17 アルマック ダイアグノスティックス リミテッド 結腸ガン遺伝子発現シグネチャーおよび使用方法
US9589099B2 (en) 2011-07-21 2017-03-07 The Chinese University Of Hong Kong Determination of gene expression levels of a cell type
CA2851388C (en) 2011-10-10 2023-11-21 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
US8632827B2 (en) 2011-12-13 2014-01-21 Avon Products, Inc Modulation of thymosin beta-4 in skin
US10407724B2 (en) 2012-02-09 2019-09-10 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US20140024546A1 (en) * 2012-05-01 2014-01-23 Synapdx Corporation Systems and methods for normalizing gene expression profiles of biological samples having a mixed cell population
DK2872891T3 (da) * 2012-07-10 2019-05-13 Nepean Blue Mountains Local Health Distr Risikostratificering ved influenza
EP2895621B1 (en) 2012-09-14 2020-10-21 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2014093053A1 (en) * 2012-12-11 2014-06-19 Avon Products, Inc. Modulation of thymosin beta-4 in skin
KR102343212B1 (ko) 2013-03-27 2021-12-23 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
SMT202100691T1 (it) 2013-07-11 2022-01-10 Modernatx Inc Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
CN103757028B (zh) * 2014-01-23 2015-09-09 南京医科大学 Osbpl2突变型基因、其鉴定方法和检测试剂盒
WO2015120482A2 (en) * 2014-02-10 2015-08-13 Baylor College Of Medicine Recurrent fusion genes identified in high-grade serous ovarian carcinoma
GB2558326B (en) 2014-09-05 2021-01-20 Population Bio Inc Methods and compositions for inhibiting and treating neurological conditions
JP6403260B2 (ja) * 2014-11-21 2018-10-10 学校法人日本大学 前立腺癌の判定、治療選択方法、予防又は治療剤
CN104611430A (zh) * 2015-01-26 2015-05-13 钱学庆 一种人类尿液中tmprss2-erg基因检测方法和引物
WO2017095960A1 (en) * 2015-11-30 2017-06-08 Synthetic Genomics, Inc. Compositions and methods for expressing genes in algae
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
US20200057068A1 (en) * 2016-11-24 2020-02-20 The Council Of The Queensland Institute Of Medical Research Determining a Cancer Prognosis
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
IL274926B2 (en) 2017-12-01 2026-04-01 Encoded Therapeutics Inc Pyrazolopyrimidines with activity against respiratory syncytial virus
CN112534070B (zh) * 2018-06-29 2024-07-30 杰克逊实验室 乳腺癌剪接变体
DE24173683T1 (de) 2018-08-08 2024-11-07 Pml Screening, Llc Verfahren zur beurteilung des risikos der entwicklung einer viruserkrankung unter verwendung eines genetischen tests
CN109593848B (zh) * 2018-11-08 2020-07-10 浙江大学 一种肿瘤相关序列、长链非编码rna及其应用
GB2582665B (en) * 2019-03-29 2021-12-29 Advanced Risc Mach Ltd Feature dataset classification
WO2020243651A1 (en) 2019-05-29 2020-12-03 Encoded Therapeutics, Inc. Compositions and methods for selective gene regulation
US12188060B2 (en) 2020-05-15 2025-01-07 Crispr Therapeutics Ag Messenger RNA encoding Cas9 for use in genome-editing systems
WO2022246204A2 (en) * 2021-05-21 2022-11-24 Ionis Pharmaceuticals, Inc. Compounds for reducing ptbp1 expression
WO2023076895A2 (en) * 2021-10-25 2023-05-04 University Of Cincinnati Molecular therapeutics for the treatment of hypertrophic cardiomyopathy and heart failure associated with mybpc3 gene mutations
EP4433595A1 (en) * 2021-11-18 2024-09-25 Resonance Health Analysis Services Pty Ltd Method for treating cyclophilin b associated diseases
CN119296651B (zh) * 2024-09-19 2025-09-19 新疆维吾尔自治区人民医院 胸主动脉夹层关键细胞类型及亚型的分类方法及装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002059373A2 (en) * 2001-01-23 2002-08-01 Irm, Llc Genes overexpressed in prostate disorders as diagnostic and therapeutic targets
WO2002062201A2 (en) * 2001-02-02 2002-08-15 Dana-Farber Cancer Institute, Inc. Rare event detection system
DE10159404A1 (de) * 2001-12-04 2003-06-26 Arevia Gmbh Verfahren zur Analyse von Gewebeproben
AU2002953327A0 (en) * 2002-12-12 2003-01-09 Monash University Methods of diagnosing prognosing and treating activin associated diseases and conditions
US20050048463A1 (en) * 2003-05-07 2005-03-03 Deng David Xing-Fei Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures
WO2005068664A2 (en) 2004-01-09 2005-07-28 The Regents Of The University Of California Cell-type-specific patterns of gene expression

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025054611A1 (en) * 2023-09-08 2025-03-13 The Trustees Of Princeton University Systems and methods for predicting high resolution cell-type-specific gene transcription and applications thereof

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JP2011229522A (ja) 2011-11-17
US20060292572A1 (en) 2006-12-28
JP2008504803A (ja) 2008-02-21
WO2005068664A2 (en) 2005-07-28
US8781750B2 (en) 2014-07-15
WO2005068664A3 (en) 2006-04-27

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