KR20070034993A - Ｐｐａｒ 조절제로서의 화합물 및 조성물 - Google Patents
Ｐｐａｒ 조절제로서의 화합물 및 조성물 Download PDFInfo
- Publication number
- KR20070034993A KR20070034993A KR1020067023769A KR20067023769A KR20070034993A KR 20070034993 A KR20070034993 A KR 20070034993A KR 1020067023769 A KR1020067023769 A KR 1020067023769A KR 20067023769 A KR20067023769 A KR 20067023769A KR 20070034993 A KR20070034993 A KR 20070034993A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- phenoxy
- dichloro
- acetic acid
- isoxazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000000217 alkyl group Chemical group 0.000 claims description 52
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57100304P | 2004-05-14 | 2004-05-14 | |
| US60/571,003 | 2004-05-14 | ||
| PCT/US2005/016672 WO2005113519A1 (en) | 2004-05-14 | 2005-05-12 | Compounds and compositions as ppar modulators |
Publications (1)
| Publication Number | Publication Date |
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| KR20070034993A true KR20070034993A (ko) | 2007-03-29 |
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| EP (1) | EP1745027A4 (enExample) |
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| RU (1) | RU2408589C2 (enExample) |
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| WO (1) | WO2005113519A1 (enExample) |
Families Citing this family (24)
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| EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
| CA2614664A1 (en) * | 2005-07-14 | 2007-01-25 | Franco Folli | Daily dosage regimen for treating diabetes, obesity,metabolic syndrome and polycystic ovary syndrome |
| CA2625646A1 (en) * | 2005-10-25 | 2007-05-03 | Merck & Co., Inc. | Combination of a dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension |
| DE102006014165A1 (de) * | 2006-03-24 | 2007-09-27 | Schebo Biotech Ag | Neue Isooxazol-Derivate und deren Verwendungen |
| TW200811164A (en) * | 2006-05-12 | 2008-03-01 | Jerini Ag | New heterocyclic compounds for the inhibition of integrins and use thereof |
| WO2008035359A2 (en) * | 2006-06-12 | 2008-03-27 | Cadila Healthcare Limited | Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives |
| US20080020014A1 (en) * | 2006-07-19 | 2008-01-24 | Paul Consigny | Implantable devices containing nuclear receptor ligands for the treatment of vascular and related disorders |
| US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| EP2229383B1 (en) * | 2007-12-04 | 2017-01-18 | F. Hoffmann-La Roche AG | Isoxazolo-pyrazine derivatives |
| PT2767536E (pt) * | 2007-12-04 | 2015-11-17 | Hoffmann La Roche | Derivados de isoxazolo-piridina |
| US20110293520A1 (en) * | 2008-06-09 | 2011-12-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN105030771B (zh) * | 2015-04-10 | 2017-11-17 | 广州市爱菩新医药科技有限公司 | 连吡啶异恶唑类化合物作为法尼醇x受体激动剂的应用 |
| CN105622536B (zh) * | 2015-12-30 | 2018-06-29 | 商丘师范学院 | 一种三氟甲基化烯基异噁唑化合物及其制备方法和应用 |
| CN105622537A (zh) * | 2016-03-01 | 2016-06-01 | 青岛大学 | 一种3,4,5-三取代异恶唑类化合物的合成方法 |
| CA3252823A1 (en) | 2016-06-13 | 2025-02-25 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| WO2017218337A1 (en) | 2016-06-13 | 2017-12-21 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| SI3600309T1 (sl) | 2017-03-28 | 2022-10-28 | Gilead Sciences, Inc. | Terapevtske kombinacije za zdravljenje bolezni jeter |
| WO2020150136A1 (en) | 2019-01-15 | 2020-07-23 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| US11524005B2 (en) | 2019-02-19 | 2022-12-13 | Gilead Sciences, Inc. | Solid forms of FXR agonists |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2088996A (en) * | 1935-11-22 | 1937-08-03 | Hoffmann La Roche | Double compounds of secondary amides of 3.5-dimethyl-isoxazole-4-carboxylic acid and process for the manufacture of same |
| DE1670249B2 (de) * | 1966-07-25 | 1974-07-18 | Bristol-Myers Co., East Syracuse, N.Y. (V.St.A.) | Verfahren zur Herstellung von 4-Isothiazolcarbonsäuren |
| GB1203039A (en) * | 1967-02-15 | 1970-08-26 | Geigy Ag J R | Process for the production of nitrofuryl derivatives |
| US3466296A (en) | 1967-05-16 | 1969-09-09 | American Home Prod | Process for the preparation of alkyl 3,5-disubstituted-isoxazole-4-carboxylates |
| DE3247454A1 (de) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| IT1228288B (it) * | 1989-01-09 | 1991-06-07 | Zambon Spa | Composti ad attivita' antiserotoninica |
| DE4219247A1 (de) * | 1992-06-12 | 1993-12-16 | Bayer Ag | Verwendung von 3-arylsubstituierten 5-Alkyl-isoxazol-4-carbonsäurederivaten zur Bekämpfung von Endoparasiten, neue 3-arylsubstituierte 5-Alkyl-isoxazol-4-carbonsäurederivate und Verfahren zu ihrer Herstellung |
| EP0885891A4 (en) * | 1996-02-27 | 2001-02-21 | Sankyo Co | ISOXAZOLE DERIVATIVES |
| PL343313A1 (en) * | 1998-04-08 | 2001-08-13 | Lilly Co Eli | Methods for inhibiting mrp1 |
| EP1102755B1 (en) * | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
| WO2001016116A1 (en) * | 1999-09-01 | 2001-03-08 | Chemrx Advanced Technologies, Inc. | Process for synthesizing isoxazolines and isoxazoles |
| CA2411813A1 (en) * | 2000-06-14 | 2001-12-20 | Eli Lilly And Company | Tricyclic compounds as mrp1-inhibitors |
| GB0119911D0 (en) * | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| AU2003278814A1 (en) * | 2002-09-13 | 2004-04-30 | Georgetown University | Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof |
| WO2005033103A1 (en) | 2003-09-12 | 2005-04-14 | Rigel Pharmaceuticals, Inc. | Quinoline compounds and their uses |
-
2005
- 2005-05-12 RU RU2006144124/04A patent/RU2408589C2/ru not_active IP Right Cessation
- 2005-05-12 KR KR1020067023769A patent/KR20070034993A/ko not_active Ceased
- 2005-05-12 EP EP05769154A patent/EP1745027A4/en not_active Withdrawn
- 2005-05-12 JP JP2007513366A patent/JP2007537286A/ja active Pending
- 2005-05-12 CA CA002564429A patent/CA2564429A1/en not_active Abandoned
- 2005-05-12 AU AU2005245411A patent/AU2005245411B2/en not_active Ceased
- 2005-05-12 CN CNA2005800196529A patent/CN1984894A/zh active Pending
- 2005-05-12 BR BRPI0511099-8A patent/BRPI0511099A/pt not_active IP Right Cessation
- 2005-05-12 US US11/596,596 patent/US7820705B2/en not_active Expired - Fee Related
- 2005-05-12 WO PCT/US2005/016672 patent/WO2005113519A1/en not_active Ceased
- 2005-05-12 MX MXPA06013196A patent/MXPA06013196A/es not_active Application Discontinuation
- 2005-05-13 AR ARP050101972A patent/AR048789A1/es unknown
- 2005-05-13 PE PE2005000536A patent/PE20060357A1/es not_active Application Discontinuation
- 2005-05-13 TW TW094115655A patent/TW200602330A/zh unknown
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2009
- 2009-07-09 AU AU2009202781A patent/AU2009202781A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06013196A (es) | 2007-02-14 |
| US7820705B2 (en) | 2010-10-26 |
| RU2408589C2 (ru) | 2011-01-10 |
| BRPI0511099A (pt) | 2007-12-26 |
| JP2007537286A (ja) | 2007-12-20 |
| AU2005245411B2 (en) | 2009-04-23 |
| AU2005245411A1 (en) | 2005-12-01 |
| TW200602330A (en) | 2006-01-16 |
| EP1745027A1 (en) | 2007-01-24 |
| US20080114044A1 (en) | 2008-05-15 |
| CN1984894A (zh) | 2007-06-20 |
| PE20060357A1 (es) | 2006-05-09 |
| AR048789A1 (es) | 2006-05-24 |
| AU2009202781A1 (en) | 2009-07-30 |
| RU2006144124A (ru) | 2008-06-20 |
| CA2564429A1 (en) | 2005-12-01 |
| WO2005113519A1 (en) | 2005-12-01 |
| EP1745027A4 (en) | 2009-06-03 |
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