KR20070004560A - 성장 인자 전달을 위한 자가조립 펩티드 친양매성 화합물들및 관련 방법들 - Google Patents

성장 인자 전달을 위한 자가조립 펩티드 친양매성 화합물들및 관련 방법들 Download PDF

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KR20070004560A
KR20070004560A KR1020067013464A KR20067013464A KR20070004560A KR 20070004560 A KR20070004560 A KR 20070004560A KR 1020067013464 A KR1020067013464 A KR 1020067013464A KR 20067013464 A KR20067013464 A KR 20067013464A KR 20070004560 A KR20070004560 A KR 20070004560A
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peptide
compound
growth factor
binding
compounds
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KR1020067013464A
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Korean (ko)
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사무엘 아이. 스터프
잭 제이. 제이. 엠. 도너스
가브리엘 에이. 실바
히더 에이. 베한나
숀 쥐. 앤쏘니
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노오쓰웨스턴 유니버시티
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Publication of KR20070004560A publication Critical patent/KR20070004560A/ko

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
KR1020067013464A 2003-12-05 2004-12-06 성장 인자 전달을 위한 자가조립 펩티드 친양매성 화합물들및 관련 방법들 KR20070004560A (ko)

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US52750403P 2003-12-05 2003-12-05
US60/527,504 2003-12-05

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US (3) US7544661B2 (US20050209145A1-20050922-C00001.png)
EP (2) EP1696945B1 (US20050209145A1-20050922-C00001.png)
JP (2) JP4851939B2 (US20050209145A1-20050922-C00001.png)
KR (1) KR20070004560A (US20050209145A1-20050922-C00001.png)
CN (2) CN102225964A (US20050209145A1-20050922-C00001.png)
AT (1) ATE541580T1 (US20050209145A1-20050922-C00001.png)
AU (2) AU2004296181A1 (US20050209145A1-20050922-C00001.png)
CA (1) CA2549164A1 (US20050209145A1-20050922-C00001.png)
ES (1) ES2380340T3 (US20050209145A1-20050922-C00001.png)
MX (1) MXPA06006388A (US20050209145A1-20050922-C00001.png)
NZ (1) NZ547671A (US20050209145A1-20050922-C00001.png)
WO (1) WO2005056039A1 (US20050209145A1-20050922-C00001.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
WO2004018628A2 (en) * 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) * 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004046167A2 (en) * 2002-11-14 2004-06-03 Northwestern University Synthesis and self-assembly of abc triblock bola peptide
KR20050100397A (ko) * 2003-02-11 2005-10-18 노오쓰웨스턴 유니버시티 나노결정질 표면 코팅을 위한 방법 및 물질, 및 이의상부로의 펩티드 양친매성 나노섬유의 부착
MXPA06006388A (es) 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos de auto-ensamble y metodos relacionados para el suministro del factor de crecimiento.
MXPA06006387A (es) * 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos ramificados, compuestos epitopes relacionados y estructuras auto-ensambladas de los mismos.
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
KR20070100948A (ko) 2005-01-21 2007-10-15 노오쓰웨스턴 유니버시티 세포의 캡슐화 방법 및 조성물
WO2006096614A2 (en) * 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
US9162005B2 (en) * 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
US8299032B2 (en) * 2005-06-27 2012-10-30 Menicon Co., Ltd. Self-assembling peptide and gel produced from the same
CN100475836C (zh) * 2005-12-09 2009-04-08 中国人民解放军军事医学科学院野战输血研究所 间充质干细胞亲和肽的筛选与用途
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
WO2007098541A1 (en) * 2006-02-28 2007-09-07 Regenertech Pty Limited Tissue regeneration ii
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
WO2009127939A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un facteur de croissance un sel soluble de cation et un support organique
CA2720203A1 (fr) * 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation et un support organique
CA2765670C (en) * 2008-06-24 2018-05-15 Bioactive Surgical, Inc. Surgical sutures incorporated with stem cells or other bioactive materials
KR20110042107A (ko) 2008-08-07 2011-04-22 바이오엑티브 써지컬, 아이엔씨. 의료 장치 및 이식물을 위한 줄기 세포 포획 및 고정화 코팅
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
US8883967B2 (en) * 2009-03-27 2014-11-11 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
JP2012523463A (ja) * 2009-04-13 2012-10-04 ノースウエスタン ユニバーシティ 軟骨再生のための新規なペプチドベースの足場およびその使用方法
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
WO2011123061A1 (en) * 2010-03-31 2011-10-06 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8940858B2 (en) * 2010-05-17 2015-01-27 Northwestern University Fibrous microcapsules and methods of assembly and use thereof
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
WO2012031015A1 (en) * 2010-09-01 2012-03-08 The Regents Of The University Of California Cell culture screen for agents that control adipogenesis and myofibroblast differentiation
EP2618821A4 (en) * 2010-09-24 2014-08-13 Brigham & Womens Hospital NANOSTRUCTURED GELS FOR CONTROLLED RELEASE OF CAPSUED MEDIUM
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2012149515A2 (en) * 2011-04-29 2012-11-01 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
US10766927B2 (en) 2012-11-25 2020-09-08 The Regents Of The University Of California Peptides that stimulate subcutaneous adipogenesis
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
IL286537B (en) 2013-03-15 2022-07-01 In3Bio Ltd Synthetic proteins that assemble themselves
ES2756531T3 (es) 2013-08-22 2020-04-27 Arch Biosurgery Inc Mallas implantables para controlar el movimiento de fluidos
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
BR112016012230A2 (pt) * 2013-11-30 2017-08-08 Agency Science Tech & Res Peptídeo hidrofóbico e/ou peptídeo-mimético, capaz de formar um hidrogel; composição ou mistura; hidrogel; uso do hidrogel; método para preparar um hidrogel; curativo de ferida ou agente cicatrizante de ferida; implante cirúrgico; composição cosmética e/ou farmacêutica e/ou um dispositivo biomédico e/ou dispositivo eletrônico; kit de peças; método in vitro ou in vivo de regeneração de tecido; método de tratamento de uma ferida e para cicatrização de ferida; dispositivo de bioimagem; e; substrato de cultura da célula 2d ou 3d
WO2015184125A1 (en) 2014-05-28 2015-12-03 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (de) 2015-01-20 2016-07-21 Emc Microcollections Gmbh Neue modular funktionalisierbare Peptid-Hydrogele
WO2016168302A1 (en) * 2015-04-14 2016-10-20 Northwestern University Supramolecular glyconanostructures
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
CN108289926A (zh) * 2015-10-14 2018-07-17 西北大学 用于生长因子递送和骨再生的纳米纤维糊剂
CA3043305A1 (en) * 2016-09-09 2018-05-24 Research Foundation Of The City University Of New York Self-assembling peptide polymer
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10752656B2 (en) 2016-10-21 2020-08-25 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
EP3548518A1 (en) 2016-11-30 2019-10-09 Universiteit Twente Functionalization of biopolymers with growth factor-binding peptides
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US10584146B2 (en) 2016-12-07 2020-03-10 Uchicago Argonne, Llc Heme peptide materials for anti-inflammatory regenerative nanobiomedicine
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
AU2018266131B2 (en) 2017-05-08 2021-07-29 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
US20210163556A1 (en) * 2018-04-06 2021-06-03 Northwestern University Bdnf mimetic peptide amphiphiles
WO2020076453A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
AU2020277404A1 (en) * 2019-05-20 2021-11-25 Convalesce Inc. Hydrogels, methods of making, and methods of use
CN110283231B (zh) * 2019-06-03 2021-04-27 中南民族大学 一种基于两亲性寡肽自组装新型溶致液晶的制备和应用
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors
KR20230104243A (ko) * 2020-11-06 2023-07-07 더 메디컬 컬리지 오브 위스콘신, 인크. 인체 미토콘드리아 분열 단백질 1의 펩타이드 억제제 및 그 사용 방법
CA3225407A1 (en) * 2021-07-29 2023-02-02 Shelby Chi YUAN Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (tgf-.beta.1) mimetic epitope
CA3229054A1 (en) * 2021-08-09 2023-02-16 Gel4Med, Inc. Self-assembling amphiphilic peptide hydrogels for treatment of nerve injury

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5110604A (en) 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
JP4215273B2 (ja) 1991-04-25 2009-01-28 ブラウン ユニヴァーシティ リサーチ ファンデーション 選択された治療物質放出用の移植可能で生体適合性の免疫遮断性ビークル
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
CA2228118A1 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US5853830A (en) 1996-06-12 1998-12-29 Hoechst Trespaphan Gmbh Transparent barrier coatings exhibiting reduced thin film interference
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
ATE244579T1 (de) 1997-01-22 2003-07-15 Univ Texas Verfahren und zusammensetzungen des gewebefaktors zur koagulation und behandlung von tumoren
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
JP4222726B2 (ja) 1997-12-02 2009-02-12 ゼン‐バイオ,インコーポレイテッド 骨芽細胞の発生および使用
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (sv) 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
ATE363292T1 (de) 1998-09-04 2007-06-15 Scios Inc Hydrogelzusammensetzungen mit kontrollierter freigabe von wachstumsfaktoren
US6207218B1 (en) 1998-09-15 2001-03-27 Isotis B.V. Method for coating medical implants
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
ES2632564T3 (es) 1999-02-01 2017-09-14 Eidgenössische Technische Hochschule Zürich Bio-materiales formados por reacción de adición nucleófila a grupos insaturados conjugados
CA2361612A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
IL145151A0 (en) 1999-03-02 2002-06-30 Univ Massachusetts Embr0yonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
CA2369579A1 (en) 1999-04-22 2000-11-02 Eidgenossische Techninische Hochschule(Eth) Controlled release of growth factors from heparin containing matrices
US20090087878A9 (en) 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
CN1362965A (zh) 1999-06-30 2002-08-07 先进细胞技术公司 细胞质转移使受体细胞去分化
US6444723B1 (en) 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
ES2304359T3 (es) * 1999-12-28 2008-10-16 The Regents Of The University Of Michigan Procedimiento de formacion ex vivo de hueso de mamiferos y usos del mismo.
US20040018969A1 (en) * 2000-01-31 2004-01-29 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001059064A2 (en) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE60100433T2 (de) 2000-02-04 2004-04-15 Chienna B.V. Proteinbeschichtung
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
JP2003531930A (ja) 2000-04-28 2003-10-28 ユニバーシティ・カレッジ・ダブリン 両親媒性大環状誘導体およびそれらの類似体
AU2001261506A1 (en) 2000-05-11 2001-11-20 University Of Southern California Discourse parsing and summarization
WO2002020724A2 (en) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Adenoviral targeting and manipulation of immune system response using targeting peptides
CA2426692C (en) 2000-10-19 2011-01-25 Eidgenossische Technische Hochschule Zurich Block copolymers for multifunctional self-assembled systems
ATE354802T1 (de) * 2000-11-06 2007-03-15 Thrasos Inc Methoden zum screening knochenmorphogenetishemimetika
CA2436740A1 (en) 2001-01-23 2002-08-01 Educational Testing Service Methods for automated essay analysis
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
ATE419333T1 (de) * 2001-02-06 2009-01-15 Massachusetts Inst Technology Peptidgerüstverkapselung von gewebszellen und verwendungen davon
US7179784B2 (en) 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
US20050260179A1 (en) 2001-11-06 2005-11-24 The General Hospital Corporation D/B/A Massachusetts General Hospital Stem and progenitor cell capture for tissue regeneration
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) * 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
WO2003090255A2 (en) 2002-04-18 2003-10-30 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
WO2004024778A2 (en) 2002-07-23 2004-03-25 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
WO2004018628A2 (en) 2002-08-21 2004-03-04 Northwestern University Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2005003292A2 (en) 2002-11-12 2005-01-13 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004046167A2 (en) 2002-11-14 2004-06-03 Northwestern University Synthesis and self-assembly of abc triblock bola peptide
KR20050100397A (ko) 2003-02-11 2005-10-18 노오쓰웨스턴 유니버시티 나노결정질 표면 코팅을 위한 방법 및 물질, 및 이의상부로의 펩티드 양친매성 나노섬유의 부착
CN100364672C (zh) 2003-02-11 2008-01-30 西北大学 纳米晶体表面涂层和肽亲水脂分子纳米纤维向其上附着的方法和材料
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
US7259140B2 (en) 2003-03-28 2007-08-21 Thomas Jefferson University Heparin-binding peptides and uses thereof
WO2004091370A2 (en) 2003-04-10 2004-10-28 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
MXPA06006388A (es) 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos de auto-ensamble y metodos relacionados para el suministro del factor de crecimiento.
MXPA06006387A (es) 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos ramificados, compuestos epitopes relacionados y estructuras auto-ensambladas de los mismos.
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
EP1740196B1 (en) 2004-03-23 2015-08-26 Lifeline Nutraceuticals Corporation Compositions and method for alleviating inflammation and oxidative stress in a mammal
KR20070100948A (ko) 2005-01-21 2007-10-15 노오쓰웨스턴 유니버시티 세포의 캡슐화 방법 및 조성물
EP1838290A2 (en) 2005-01-21 2007-10-03 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
WO2006096614A2 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
WO2007022287A2 (en) 2005-08-15 2007-02-22 Vegenics Limited Modified vegf and pdgf with improved angiogenic properties
CN1915438A (zh) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
JP2012523463A (ja) * 2009-04-13 2012-10-04 ノースウエスタン ユニバーシティ 軟骨再生のための新規なペプチドベースの足場およびその使用方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀

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