KR20060120253A - 옥사세펨의 결정 - Google Patents
옥사세펨의 결정 Download PDFInfo
- Publication number
- KR20060120253A KR20060120253A KR1020067016586A KR20067016586A KR20060120253A KR 20060120253 A KR20060120253 A KR 20060120253A KR 1020067016586 A KR1020067016586 A KR 1020067016586A KR 20067016586 A KR20067016586 A KR 20067016586A KR 20060120253 A KR20060120253 A KR 20060120253A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl acetate
- crystals
- flomoxef
- hydrate
- solvate
- Prior art date
Links
- 0 *SCC(N[C@@](C1OCC(CSc2nnn[n]2CCO)C=C(C(O)=O)N11)(C1=*)O)=O Chemical compound *SCC(N[C@@](C1OCC(CSc2nnn[n]2CCO)C=C(C(O)=O)N11)(C1=*)O)=O 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D505/10—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D505/12—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7
- C07D505/14—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7 with hetero atoms directly attached in position 7
- C07D505/16—Nitrogen atoms
- C07D505/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D505/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D505/24—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by doubly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims (6)
- 제 1 항에 있어서, 1수화물인 수화물 또는 수화물 결정.
- 제 1 항 또는 제 2 항에 있어서, 분말 X-선 회절 패턴에서 스페이싱 d=8.31, 7.00, 6.11, 5.43, 4.47, 4.35, 4.19, 4.15, 3.95, 3.81, 3.50, 3.32, 2.96 (단위: 옹스트롬) 에 주요 피크를 가지는 수화물 결정.
- 제 4 항에 있어서, 0.5 메틸 아세테이트 용매화물인 메틸 아세테이트 용매화물 또는 메틸 아세테이트 용매화물 결정.
- 제 4 항 또는 제 5 항에 있어서, 분말 X-선 회절 패턴에서 스페이싱 d=10.42, 6.32, 4.96, 4.62, 4.56, 4.36, 4.23, 3.97, 3.93, 3.79, 3.47, 2.79 (단위: 옹스트롬) 에 주요 피크를 가지는 메틸 아세테이트 용매화물 결정.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2004-00043824 | 2004-02-20 | ||
JP2004043824 | 2004-02-20 | ||
JPJP-P-2004-00053283 | 2004-02-27 | ||
JP2004053283 | 2004-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20060120253A true KR20060120253A (ko) | 2006-11-24 |
KR100832757B1 KR100832757B1 (ko) | 2008-05-27 |
Family
ID=34703384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067016586A KR100832757B1 (ko) | 2004-02-20 | 2005-02-18 | 옥사세펨의 결정 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP4530287B2 (ko) |
KR (1) | KR100832757B1 (ko) |
CN (2) | CN101440098B (ko) |
TW (1) | TWI338008B (ko) |
WO (1) | WO2005058914A1 (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2543350C (en) | 2003-10-24 | 2011-04-26 | Adhesives Research, Inc. | Disintegratable films for diagnostic devices |
CN102952149B (zh) * | 2012-11-09 | 2015-06-24 | 浙江新和成股份有限公司 | 一种氟氧头孢中间体的一锅合成法 |
KR101314500B1 (ko) | 2012-12-28 | 2013-10-07 | 제일약품주식회사 | 안정성이 개선된 옥사세펨 제제 및 그 제조방법 |
CN105801601B (zh) * | 2016-04-02 | 2018-01-26 | 丽珠医药集团股份有限公司 | 一种氟氧头孢钠合成方法 |
CN108424418A (zh) * | 2017-02-15 | 2018-08-21 | 山东致纯医药科技有限公司 | 一种氟氧头孢钠杂质 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59139385A (ja) | 1982-12-23 | 1984-08-10 | Shionogi & Co Ltd | フルオロメチルチオオキサセフアロスポリン |
JPS59231090A (ja) * | 1983-06-14 | 1984-12-25 | Shionogi & Co Ltd | フルオロメチルチオオキサセフアロスポリン |
JPH03279329A (ja) * | 1990-03-27 | 1991-12-10 | Banyu Pharmaceut Co Ltd | セファマイシンおよびセファロスポリンからなる抗菌剤 |
JP3279329B2 (ja) * | 1991-11-01 | 2002-04-30 | クルップ・プレスタ・アーゲー | カムシャフトの製造装置 |
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2005
- 2005-02-18 KR KR1020067016586A patent/KR100832757B1/ko active IP Right Grant
- 2005-02-18 CN CN2008101816721A patent/CN101440098B/zh not_active Expired - Fee Related
- 2005-02-18 CN CNB2005800054157A patent/CN100509819C/zh not_active Expired - Fee Related
- 2005-02-18 TW TW094104742A patent/TWI338008B/zh not_active IP Right Cessation
- 2005-02-18 JP JP2005516398A patent/JP4530287B2/ja not_active Expired - Fee Related
- 2005-02-18 WO PCT/JP2005/002607 patent/WO2005058914A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN101440098B (zh) | 2011-07-13 |
JPWO2005058914A1 (ja) | 2007-07-12 |
WO2005058914A1 (ja) | 2005-06-30 |
CN100509819C (zh) | 2009-07-08 |
TW200533672A (en) | 2005-10-16 |
CN1922191A (zh) | 2007-02-28 |
TWI338008B (en) | 2011-03-01 |
KR100832757B1 (ko) | 2008-05-27 |
CN101440098A (zh) | 2009-05-27 |
JP4530287B2 (ja) | 2010-08-25 |
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