KR20060080818A - 시부트라민의 술폰산염 - Google Patents
시부트라민의 술폰산염 Download PDFInfo
- Publication number
- KR20060080818A KR20060080818A KR1020050001404A KR20050001404A KR20060080818A KR 20060080818 A KR20060080818 A KR 20060080818A KR 1020050001404 A KR1020050001404 A KR 1020050001404A KR 20050001404 A KR20050001404 A KR 20050001404A KR 20060080818 A KR20060080818 A KR 20060080818A
- Authority
- KR
- South Korea
- Prior art keywords
- sibutramine
- sulfonate
- acid
- para
- ray diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960004425 sibutramine Drugs 0.000 title claims abstract description 114
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 title claims abstract description 102
- 150000003871 sulfonates Chemical class 0.000 title description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims abstract description 34
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims abstract description 25
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims abstract description 21
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims abstract description 19
- 229940077388 benzenesulfonate Drugs 0.000 claims abstract description 18
- AFAXGSQYZLGZPG-UHFFFAOYSA-L ethane-1,2-disulfonate Chemical compound [O-]S(=O)(=O)CCS([O-])(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-L 0.000 claims abstract description 15
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- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 claims description 7
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- 239000012442 inert solvent Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 abstract description 23
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 abstract description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 45
- KFNNPQDSPLWLCX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine;hydron;chloride;hydrate Chemical compound O.Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 KFNNPQDSPLWLCX-UHFFFAOYSA-N 0.000 description 23
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Images
Classifications
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/05—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing at least two sulfo groups bound to the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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- C07—ORGANIC CHEMISTRY
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050001404A KR20060080818A (ko) | 2005-01-06 | 2005-01-06 | 시부트라민의 술폰산염 |
| PCT/KR2006/000072 WO2006073291A1 (en) | 2005-01-06 | 2006-01-06 | A sulphonic acid salt of sibutramine |
| US10/580,135 US7429679B2 (en) | 2005-01-06 | 2006-01-06 | Sulphonic acid salt of sibutramine |
| CNA2006800018244A CN101098849A (zh) | 2005-01-06 | 2006-01-06 | 西布曲明的磺酸盐 |
| JP2007550300A JP2008526835A (ja) | 2005-01-06 | 2006-01-06 | シブトラミンのスルホン酸塩 |
| EP06700097A EP1846360A4 (en) | 2005-01-06 | 2006-01-06 | SULFONIC ACID SALT OF SIBUTRAMINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050001404A KR20060080818A (ko) | 2005-01-06 | 2005-01-06 | 시부트라민의 술폰산염 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060080818A true KR20060080818A (ko) | 2006-07-11 |
Family
ID=36647750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020050001404A Abandoned KR20060080818A (ko) | 2005-01-06 | 2005-01-06 | 시부트라민의 술폰산염 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7429679B2 (enExample) |
| EP (1) | EP1846360A4 (enExample) |
| JP (1) | JP2008526835A (enExample) |
| KR (1) | KR20060080818A (enExample) |
| CN (1) | CN101098849A (enExample) |
| WO (1) | WO2006073291A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100800561B1 (ko) * | 2006-03-29 | 2008-02-04 | 주식회사 삼오제약 | 시부트라민 술포닐염의 제조방법 및 이를 포함하는비만관련 질환 예방 및 치료용 약학조성물 |
| KR101007927B1 (ko) * | 2008-12-24 | 2011-01-14 | 주식회사 셀트리온제약 | 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| KR101374939B1 (ko) * | 2013-10-18 | 2014-03-14 | 제일약품주식회사 | 이토프라이드 염산염 제조에 사용되는 신규 중간체염, 이의 제조방법 및 이를 이용한 이토프라이드 염산염의 제조방법 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
| JP2008526836A (ja) * | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
| CN101555214B (zh) * | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
| CN102786444A (zh) * | 2012-07-24 | 2012-11-21 | 上海瑞博化学有限公司 | 一种西布曲明类似物的磺酸盐的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402641D0 (en) | 1994-02-11 | 1994-04-06 | Boots Co Plc | Therapeutic agents |
| GB9619961D0 (en) * | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| US6331571B1 (en) * | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| BR0009159A (pt) * | 1999-03-19 | 2001-12-26 | Knoll Gmbh | Método de controle do ganho de peso associadocom drogas terapêuticas |
| AU3895300A (en) * | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| HRP20050307A2 (en) * | 2002-10-05 | 2006-12-31 | Hanmi Pharm. Co. Ltd. | Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate |
| KR20060080817A (ko) * | 2005-01-06 | 2006-07-11 | 씨제이 주식회사 | 시부트라민의 디카복실산염 |
| JP2008526836A (ja) * | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
-
2005
- 2005-01-06 KR KR1020050001404A patent/KR20060080818A/ko not_active Abandoned
-
2006
- 2006-01-06 US US10/580,135 patent/US7429679B2/en not_active Expired - Fee Related
- 2006-01-06 CN CNA2006800018244A patent/CN101098849A/zh active Pending
- 2006-01-06 JP JP2007550300A patent/JP2008526835A/ja not_active Withdrawn
- 2006-01-06 WO PCT/KR2006/000072 patent/WO2006073291A1/en not_active Ceased
- 2006-01-06 EP EP06700097A patent/EP1846360A4/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100800561B1 (ko) * | 2006-03-29 | 2008-02-04 | 주식회사 삼오제약 | 시부트라민 술포닐염의 제조방법 및 이를 포함하는비만관련 질환 예방 및 치료용 약학조성물 |
| KR101007927B1 (ko) * | 2008-12-24 | 2011-01-14 | 주식회사 셀트리온제약 | 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| KR101374939B1 (ko) * | 2013-10-18 | 2014-03-14 | 제일약품주식회사 | 이토프라이드 염산염 제조에 사용되는 신규 중간체염, 이의 제조방법 및 이를 이용한 이토프라이드 염산염의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070191481A1 (en) | 2007-08-16 |
| CN101098849A (zh) | 2008-01-02 |
| JP2008526835A (ja) | 2008-07-24 |
| WO2006073291A1 (en) | 2006-07-13 |
| US7429679B2 (en) | 2008-09-30 |
| EP1846360A1 (en) | 2007-10-24 |
| EP1846360A4 (en) | 2010-09-22 |
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