KR20060054807A - Cosmetics improving for atopy skin - Google Patents

Abstract

The present invention relates to cosmetics for improving atopic skin, and more particularly, to cosmetics for improving atopy comprising extracts extracted from leaves or stems of cedar as an active ingredient.

Atopic skin improvement cosmetics of the present invention is safe for the human body, excellent effect of improving or preventing atopic skin, is a cosmetic composition derived from natural products that can prevent the appearance of resistant bacteria.

Atopy, Duyang, Baeksan Tea, Cosmetics

Description

Cosmetics for improving atopy skin {COSMETICS IMPROVING FOR ATOPY SKIN}

The present invention relates to cosmetics for improving atopic skin, particularly safe for the human body, having an excellent effect of improving or preventing atopic skin, and related to cosmetics for improving atopy skin, comprising a fragrance extract as an active ingredient that can prevent the appearance of resistant bacteria. will be.

Atopy is a series of allergic symptoms that occur in the skin, respiratory mucosa, eye mucosa, and intestinal mucosa in individuals with atopic inducers. People with atopic inducers often have urticaria reactions in skin tests for protein substances frequently encountered in the external environment, such as house dust, mites, animal hair, food, pollen, and mold, and when eating or inhaling certain protein substances. Symptoms include itching, skin attacks, angioedema, sneezing, runny nose, stuffy nose, conjunctival hyperemia, and nausea.

Allergic diseases caused by atopy-inducing factors include atopic dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, allergic enteritis, and atopic urticaria. These diseases are dependent solely on the genetic predisposition, environment, and age of each patient. Or several diseases may appear at the same time.                         

Atopic dermatitis is a chronic eczema that begins in childhood and childhood and recurs and worsens in adulthood. The importance of the role of bacteria in the cause and treatment of eczema lesions has long been of interest. Recently, it has been known that Staphylococcus aureus , a bacterium known as Staphylococcus aureus , frequently forms colonies, increases its amount, and plays an important role in the development and exacerbation of atopic dermatitis.

In other words, the severity of atopic dermatitis correlated with the density of Staphylococcus aureus and the number of bacteria decreased significantly according to clinical improvement. The Staphylococcus aureus is detected in less than 5% of the normal human skin, but in more than 90% of the lesions of atopic dermatitis, it secretes various exotoxins and these exotoxins act as super antigens. It aggravates atopic dermatitis by stimulating skin lesions and inflammatory cells in the blood. In particular, exocytosis secreted by Staphylococcus aureus acts as a superantigen that stimulates T cells 1000 times more powerfully than conventional antigens, exacerbating and sustaining inflammation.

Therefore, based on these findings, there is a report that the combination of antibiotics targeting Staphylococcus aureus (TARGET) showed a better effect than the use of conventional steroids alone for the treatment of atopic dermatitis. However, the emergence of resistant bacteria is also emerging as a side effect of the use of antibiotics.

In fact, in the treatment of Staphylococcus aureus infection, penicillin has been widely used since the 1950s, but since 1964, more powerful antibiotics have been developed due to the abuse of antibiotics. did.

In addition, Korean Patent Application No. 10-2002-0060286 applying antimicrobial components derived from natural products and preventing the emergence of resistant bacteria due to overuse of these antibiotics has been proposed for atopic dermatitis alleviation and prevention cosmetic composition containing the sesame extract, Korean patent application No. 10-2003-0038851 contains extracts obtained by mixing soybean fermented by Baek, Jaso, Echinacea and Bacillus subtilis in a weight ratio of 2 to 30: 1 to 25: 1 to 25: 6 to 35. Cosmetics having improved atopic healing properties have been disclosed, but there is still a need for a composition derived from natural products which is safe for the human body and is more effective in treating and preventing atopic skin.

In order to solve the problems of the prior art as described above, the present invention is safe for the human body, excellent in improving or preventing atopic skin, and to provide a cosmetic for improving atopic skin derived from natural products that can prevent the appearance of resistant bacteria. do.

In order to achieve the above object, the present invention provides a cosmetic composition for improving atopic skin comprising an extract extracted from the leaves or stems of the fragrance as an active ingredient.

Hereinafter, the present invention will be described in detail.

The present inventors have confirmed that the extract extracted from the leaves or stems of the fennel has a very excellent therapeutic and prophylactic effect on atopic skin and is safe for the human body and has no side effects such as the appearance of resistant bacteria. .

Atopic skin improvement cosmetics of the present invention is characterized in that it comprises an extract extracted from the leaves or stems of the fragrance as an active ingredient.

The fragrance used in the present invention is not only general fragrance ( Ledum palustre L. var. Angustum N. Busch ) but also can be applied to a number of varieties such as leafy coriander ( Ledum palustre L. var. Diversipilosum ), cedar heading to be. Preferably, the leaves or stems of cedar ( Ledum palustre L. var. Angustum N. Busch ) collected from Mt.

In addition, the method of obtaining an extract of the fragrance in the present invention may be applied to conventional methods of extracting the active ingredient from the plant. One example is a supercritical fluid extraction method, steam extraction method or solvent extraction method. Preferably, since the extract is obtained at a relatively low temperature, it is possible to prevent decomposition and deterioration due to heat, and to separate the components and the like to have excellent selectivity, and to use a supercritical fluid extraction method for obtaining a high purity product. The leaves or stems of the fennel may be chopped and immersed in a lower alcohol such as ethanol, methanol, propanol or butanol or an aqueous solution of alcohol, and then extracted.

 In addition, the extract of the fragrance is not only essential oil components of antiseptics showing antimicrobial activity among the extracts of the fragrance, but also a-pinene (a- pinene), camphene (camphene), sabinene (myrbinne), mycene (myrcene), p-between P-cymene, limonene, sabinol, pinocarvone, myrtenal, terpen-4-01, terminin-4-01, cumininaldehyde Contains caryophyllene, allo-aromadendrene, carvone, ledol and eudesomol to relieve skin irritation and treat atopic dermatitis And the prevention effect is more excellent, there is a feature that is particularly small side effects to the human body.

If the atopy skin improvement cosmetics of the present invention includes the extract of the fragrance, the formulation is not particularly limited, and the formulation of the cosmetic is a skin lotion (cosmetic water), nutrition lotion, nutrition cream, massage cream, face wash foam, face wash water It can be manufactured in various kinds such as, pack or baby powder, and includes skin extract (cosmetic water), nutrition lotion, nutrition cream, massage cream, face wash foam, face water, pack or Conventional methods that can be applied in the manufacture of baby powder can be applied. Preferably, the content of the fragrance extract in the cosmetics for improving atopic skin is 0.1 to 30% by weight, and if it contains too small an amount out of the above range, the therapeutic and prophylactic effect of the skin of the atopy is insignificant, and the amount is too large. If it contains, skin problems may occur.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention, and the scope of the present invention is not limited to the following examples.

Example 1

Steam distillation was carried out as follows to obtain the extract from the fragrance. First, the cedar leaves and stems were collected and chopped. Then, 500 ml to 1 L of distilled water was added to 2 L and 5 L flasks, which were heated for 7 to 9 hours using a Karlsruker apparatus. After that, the essential oil component of the upper layer was collected using diethyl ether, and separated by defiltration with anhydrous sodium sulfate. In addition, the liquid extract from which the essential oil component of the upper layer was separated was evaporated under reduced pressure at 40 or less, and concentrated at the same time to remove the solvent.

Example 2

100 g of leaves and stems of the fragrance were immersed and extracted in 1 Kg of 40% ethanol aqueous solution for 3 days, and then filtered to prepare 500 g of the fragrance extract.

[Experiment 1]

In order to measure the bactericidal power of the fennel extracts prepared in Examples 1 and 2, the Staphylococcus aureus was measured by using a minimal inhibition concentration (MIC) measurement method. As a result of the measurement, the extract of Perfume was confirmed that the antimicrobial effect was twice as good as that measured by the comparative example.

[Examples 3 to 6 and Comparative Example 1]

Using the fragrance extract prepared in Example 1 to the content of the fragrance extract to 0.1% by weight, 0.5% by weight, 1.0% by weight and 10.0% by weight, by applying the base and the content ratio applied to the conventional lotion production, respectively The lotions of Examples 3-6 were prepared. Comparative Example is a lotion that does not contain a fragrance extract, the other components were prepared in the same manner as in Examples 3 to 6.                     

The improvement effect of atopic skin was measured for the lotions prepared in Example 5 and Comparative Example 1. The method of measuring 5 to 20 years old atopic dermatitis patients with atopic dermatitis more than 2 years to the affected area twice a day 30 days a day after applying the cosmetics prepared in Example 5 and Comparative Example 1 Foreskin skin improvement was observed. As a result, the cosmetics prepared in Example 5 of the present invention had a marked improvement in atopic skin in 90% or more of patients, but in the case of the cosmetics of Comparative Example 1, only 10% of patients had a slight skin improvement effect. There was only.

Atopic skin improvement cosmetics according to the present invention is safe for the human body, has a superior or preventive effect to improve atopic skin, and is a cosmetic composition derived from natural products that can prevent the appearance of resistant bacteria.

Claims (4)

Atopic skin improvement cosmetics comprising an extract extracted from the leaves or stems of the fragrance as an active ingredient. The method of claim 1, The extract of the fragrance is a-pinene (a- pinene), camphene (camphene), sabinene (sabinene), myrsen (myrcene), p-cymene (limonene), sabinol (sabinol) ), Pinocarvone, myrtenal, terpen-4-01, terpen-4-01, cumininaldehyde, caryophyllene, allo-aromadendrene A cosmetic composition for improving atopy skin, comprising at least one compound selected from the group consisting of carvone, redol and eudesomol. The method of claim 1, Formulation of the cosmetic is a skin lotion (cosmetics), nourishing lotion, nourishing cream, massage cream, face wash foam, face wash, pack or baby powder, characterized in that atopic dermatological improvement cosmetics. The method of claim 1, Atopic dermatological improvement cosmetics, characterized in that the content of the fragrance extract in the cosmetics is 0.1 to 30% by weight.