KR20050051688A - 에포틸론(Еｐｏ) Ｄ ＋ 5-플루오로우라실(ＦＵ)/겜시타빈 - Google Patents
에포틸론(Еｐｏ) Ｄ ＋ 5-플루오로우라실(ＦＵ)/겜시타빈 Download PDFInfo
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- KR20050051688A KR20050051688A KR1020057006143A KR20057006143A KR20050051688A KR 20050051688 A KR20050051688 A KR 20050051688A KR 1020057006143 A KR1020057006143 A KR 1020057006143A KR 20057006143 A KR20057006143 A KR 20057006143A KR 20050051688 A KR20050051688 A KR 20050051688A
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- Prior art keywords
- epothilone
- dehydroepothilone
- cancer
- epothilones
- nucleoside
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| US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| WO2007015578A1 (ja) | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を検定する方法 |
| CA2652442C (en) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| EP2065372B1 (en) | 2006-08-28 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| WO2008088088A1 (ja) | 2007-01-19 | 2008-07-24 | Eisai R & D Management Co., Ltd. | 膵癌治療用組成物 |
| US8962655B2 (en) | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| CN101848895B (zh) | 2007-11-09 | 2013-10-23 | 卫材R&D管理有限公司 | 血管新生抑制物质和抗肿瘤性铂络合物的组合使用 |
| CN103037903A (zh) | 2010-05-18 | 2013-04-10 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
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| EP2714937B1 (en) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
| NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| CN113683564A (zh) | 2014-08-28 | 2021-11-23 | 卫材R&D管理有限公司 | 高纯度喹啉衍生物及其生产方法 |
| LT3263106T (lt) | 2015-02-25 | 2024-01-10 | Eisai R&D Management Co., Ltd. | Chinolino darinių kartumo sumažinimo būdas |
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| CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
| RU2718048C2 (ru) | 2015-08-20 | 2020-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
| CN107041886A (zh) * | 2016-02-06 | 2017-08-15 | 北京华昊中天生物技术有限公司 | 脱环氧埃坡霉素衍生物制剂、制备及其治疗肿瘤的应用 |
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| US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
| US6262094B1 (en) * | 1999-02-22 | 2001-07-17 | Bristol-Myers Squibb Company | C-21 modified epothilones |
| US6291684B1 (en) * | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6664288B1 (en) * | 1999-04-14 | 2003-12-16 | Dana Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| CA2440555A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
| KR20040078123A (ko) * | 2002-01-14 | 2004-09-08 | 노파르티스 아게 | 에포틸론 및 대사길항물질을 포함하는 조합물 |
-
2003
- 2003-10-09 MX MXPA05003706A patent/MXPA05003706A/es not_active Application Discontinuation
- 2003-10-09 WO PCT/US2003/032148 patent/WO2004032872A2/en not_active Ceased
- 2003-10-09 RU RU2005114018/14A patent/RU2005114018A/ru not_active Application Discontinuation
- 2003-10-09 KR KR1020057006143A patent/KR20050051688A/ko not_active Withdrawn
- 2003-10-09 CN CNB2003801009323A patent/CN1297258C/zh not_active Expired - Fee Related
- 2003-10-09 BR BR0315169-7A patent/BR0315169A/pt not_active IP Right Cessation
- 2003-10-09 AU AU2003279923A patent/AU2003279923A1/en not_active Abandoned
- 2003-10-09 JP JP2004543655A patent/JP2006504745A/ja active Pending
- 2003-10-09 EP EP03773239A patent/EP1551378A4/en not_active Withdrawn
- 2003-10-09 CA CA002499682A patent/CA2499682A1/en not_active Abandoned
-
2004
- 2004-05-03 US US10/683,203 patent/US20040167097A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1703208A (zh) | 2005-11-30 |
| WO2004032872A2 (en) | 2004-04-22 |
| WO2004032872A3 (en) | 2004-11-11 |
| RU2005114018A (ru) | 2006-01-20 |
| EP1551378A4 (en) | 2006-09-06 |
| JP2006504745A (ja) | 2006-02-09 |
| AU2003279923A1 (en) | 2004-05-04 |
| CN1297258C (zh) | 2007-01-31 |
| CA2499682A1 (en) | 2004-04-22 |
| MXPA05003706A (es) | 2005-07-01 |
| BR0315169A (pt) | 2005-08-23 |
| US20040167097A1 (en) | 2004-08-26 |
| EP1551378A2 (en) | 2005-07-13 |
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| PA0105 | International application |
Patent event date: 20050408 Patent event code: PA01051R01D Comment text: International Patent Application |
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