CA2499682A1 - Epo d + 5-fu/gemcitabine - Google Patents
Epo d + 5-fu/gemcitabine Download PDFInfo
- Publication number
- CA2499682A1 CA2499682A1 CA002499682A CA2499682A CA2499682A1 CA 2499682 A1 CA2499682 A1 CA 2499682A1 CA 002499682 A CA002499682 A CA 002499682A CA 2499682 A CA2499682 A CA 2499682A CA 2499682 A1 CA2499682 A1 CA 2499682A1
- Authority
- CA
- Canada
- Prior art keywords
- epothilone
- dehydroepothilone
- group
- cancer
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- XOZIUKBZLSUILX-UHFFFAOYSA-N desoxyepothilone B Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC(C)=CCC1C(C)=CC1=CSC(C)=N1 XOZIUKBZLSUILX-UHFFFAOYSA-N 0.000 claims abstract description 48
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| EP3187491A4 (en) | 2014-08-28 | 2018-08-01 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
| US20180028662A1 (en) | 2015-02-25 | 2018-02-01 | Eisai R&D Management Co., Ltd. | Method for Suppressing Bitterness of Quinoline Derivative |
| KR20240064733A (ko) | 2015-03-04 | 2024-05-13 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| CA2988707C (en) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer |
| CN108135894B (zh) | 2015-08-20 | 2021-02-19 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
| CN107041886A (zh) * | 2016-02-06 | 2017-08-15 | 北京华昊中天生物技术有限公司 | 脱环氧埃坡霉素衍生物制剂、制备及其治疗肿瘤的应用 |
| CN110072528B (zh) | 2017-02-08 | 2022-04-26 | 卫材R&D管理有限公司 | 治疗肿瘤的药物组合物 |
| WO2018212202A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1386922B1 (en) * | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
| EE04852B1 (et) * | 1999-02-22 | 2007-06-15 | Gesellschaft Fuer Biotechnologische Forschung Mbh | C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine ja ravimkoostise kasutamine vähkkasvajate või teiste proliferatiivsete haiguste ravimisel |
| US6291684B1 (en) * | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| ES2273688T3 (es) * | 1999-04-14 | 2007-05-16 | Dana-Farber Cancer Institute, Inc. | Procedimiento y composicion para el tratamiento de cancer. |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| ATE554756T1 (de) * | 2001-03-14 | 2012-05-15 | Bristol Myers Squibb Co | Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen |
| TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
| AU2003235761A1 (en) * | 2002-01-14 | 2003-07-24 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
-
2003
- 2003-10-09 BR BR0315169-7A patent/BR0315169A/pt not_active IP Right Cessation
- 2003-10-09 RU RU2005114018/14A patent/RU2005114018A/ru not_active Application Discontinuation
- 2003-10-09 WO PCT/US2003/032148 patent/WO2004032872A2/en not_active Ceased
- 2003-10-09 EP EP03773239A patent/EP1551378A4/en not_active Withdrawn
- 2003-10-09 CA CA002499682A patent/CA2499682A1/en not_active Abandoned
- 2003-10-09 MX MXPA05003706A patent/MXPA05003706A/es not_active Application Discontinuation
- 2003-10-09 AU AU2003279923A patent/AU2003279923A1/en not_active Abandoned
- 2003-10-09 JP JP2004543655A patent/JP2006504745A/ja active Pending
- 2003-10-09 CN CNB2003801009323A patent/CN1297258C/zh not_active Expired - Fee Related
- 2003-10-09 KR KR1020057006143A patent/KR20050051688A/ko not_active Withdrawn
-
2004
- 2004-05-03 US US10/683,203 patent/US20040167097A1/en not_active Abandoned
Also Published As
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|---|---|
| RU2005114018A (ru) | 2006-01-20 |
| WO2004032872A2 (en) | 2004-04-22 |
| EP1551378A2 (en) | 2005-07-13 |
| AU2003279923A1 (en) | 2004-05-04 |
| WO2004032872A3 (en) | 2004-11-11 |
| EP1551378A4 (en) | 2006-09-06 |
| JP2006504745A (ja) | 2006-02-09 |
| MXPA05003706A (es) | 2005-07-01 |
| KR20050051688A (ko) | 2005-06-01 |
| US20040167097A1 (en) | 2004-08-26 |
| CN1703208A (zh) | 2005-11-30 |
| CN1297258C (zh) | 2007-01-31 |
| BR0315169A (pt) | 2005-08-23 |
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| FZDE | Discontinued |