KR20050050102A - ＩｇＥ를 조절하고 세포 증식을 억제하기 위한페닐-아자-벤즈이미다졸 화합물 - Google Patents
ＩｇＥ를 조절하고 세포 증식을 억제하기 위한페닐-아자-벤즈이미다졸 화합물 Download PDFInfo
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- KR20050050102A KR20050050102A KR1020057004331A KR20057004331A KR20050050102A KR 20050050102 A KR20050050102 A KR 20050050102A KR 1020057004331 A KR1020057004331 A KR 1020057004331A KR 20057004331 A KR20057004331 A KR 20057004331A KR 20050050102 A KR20050050102 A KR 20050050102A
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- South Korea
- Prior art keywords
- substituted
- alkyl
- group
- heteroaryl
- naphthyl
- Prior art date
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| CA2441177A1 (en) * | 2001-03-12 | 2002-09-19 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| CA2533990A1 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| JP2007513184A (ja) | 2003-12-04 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なキノキサリン |
| ATE384723T1 (de) * | 2004-10-13 | 2008-02-15 | Merck Patent Gmbh | Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs |
| CN101087786A (zh) * | 2004-12-23 | 2007-12-12 | 霍夫曼-拉罗奇有限公司 | 杂环氨基甲酸酯衍生物，它们的制备及作为药剂的应用 |
| CA2589779A1 (en) | 2004-12-23 | 2006-06-29 | F. Hoffmann-La Roche Ag | Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US7776878B2 (en) | 2005-08-01 | 2010-08-17 | Hoffmann-La Roche Inc. | Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents |
| CN101511828A (zh) | 2006-09-06 | 2009-08-19 | 霍夫曼-拉罗奇有限公司 | 作为蛋白激酶抑制剂的杂芳基衍生物 |
| CA2716951A1 (en) | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| EP2935253B1 (en) | 2012-12-21 | 2018-08-01 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| GB201302927D0 (en) | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| WO2015002754A2 (en) | 2013-06-21 | 2015-01-08 | Zenith Epigenetics Corp. | Novel bicyclic bromodomain inhibitors |
| WO2015015318A2 (en) | 2013-07-31 | 2015-02-05 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
| TWI674263B (zh) | 2013-12-19 | 2019-10-11 | 瑞士商諾華公司 | 用於治療寄生蟲疾病之化合物及組合物 |
| CN103819398B (zh) * | 2014-01-24 | 2016-05-04 | 河北科技大学 | 4-氨基-2-氯-3-硝基吡啶的合成方法 |
| US10005792B2 (en) | 2014-09-03 | 2018-06-26 | Ctxt Pty. Ltd. | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors |
| GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| WO2016034673A1 (en) | 2014-09-03 | 2016-03-10 | Ctxt Pty Ltd | Tetrahydroisoquinoline derived prmt5-inhibitors |
| WO2016087942A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridines as bromodomain inhibitors |
| WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| CA3007168A1 (en) * | 2015-12-14 | 2017-06-22 | Zenith Epigenetics Ltd. | 1h-imidazo[4,5-b]pyridinyl and 2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridinyl heterocyclic bet bromodomain inhibitors |
| GB201604030D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604029D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
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| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| US11767321B2 (en) | 2020-10-05 | 2023-09-26 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
| US20220127231A1 (en) * | 2020-10-27 | 2022-04-28 | Shilpa Medicare Ltd | Process for the prepartion of amifampridine phosphate |
| KR102818206B1 (ko) * | 2021-07-12 | 2025-06-11 | 한양대학교 에리카산학협력단 | 인다졸일 벤즈이미다졸 유도체 또는 이의 약학적으로 허용가능한 염 및 이의 용도 |
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| US3985891A (en) * | 1973-02-03 | 1976-10-12 | Boehringer Ingelheim Gmbh | 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof |
| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) * | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| WO1986006739A1 (en) | 1985-05-03 | 1986-11-20 | The Foxboro Company | Distillation cut point control |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US5206257A (en) * | 1987-03-05 | 1993-04-27 | May & Baker Limited | Pesticidal method using 2-phenylimidazole derivatives |
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-
2003
- 2003-09-10 TW TW092124975A patent/TWI276631B/zh not_active IP Right Cessation
- 2003-09-12 KR KR1020057004331A patent/KR20050050102A/ko not_active Withdrawn
- 2003-09-12 BR BR0314235-3A patent/BR0314235A/pt not_active IP Right Cessation
- 2003-09-12 WO PCT/US2003/030962 patent/WO2004024897A2/en not_active Ceased
- 2003-09-12 AR ARP030103321A patent/AR041252A1/es not_active Application Discontinuation
- 2003-09-12 RU RU2005109911/04A patent/RU2005109911A/ru not_active Application Discontinuation
- 2003-09-12 PE PE2003000933A patent/PE20050036A1/es not_active Application Discontinuation
- 2003-09-12 JP JP2004536644A patent/JP2006503048A/ja not_active Withdrawn
- 2003-09-12 US US10/661,296 patent/US7256287B2/en not_active Expired - Fee Related
- 2003-09-12 CN CNA038250934A patent/CN1694889A/zh active Pending
- 2003-09-12 AU AU2003279729A patent/AU2003279729A1/en not_active Abandoned
- 2003-09-12 PL PL03375811A patent/PL375811A1/xx not_active Application Discontinuation
- 2003-09-12 CA CA002498495A patent/CA2498495A1/en not_active Abandoned
- 2003-09-12 EP EP03773067A patent/EP1546157A4/en not_active Withdrawn
- 2003-09-12 NZ NZ538547A patent/NZ538547A/en unknown
- 2003-09-12 MX MXJL05000010A patent/MXJL05000010A/es not_active Application Discontinuation
-
2005
- 2005-04-05 ZA ZA200502738A patent/ZA200502738B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006503048A (ja) | 2006-01-26 |
| US20040116466A1 (en) | 2004-06-17 |
| WO2004024897A2 (en) | 2004-03-25 |
| NZ538547A (en) | 2007-05-31 |
| AR041252A1 (es) | 2005-05-11 |
| ZA200502738B (en) | 2007-04-25 |
| TW200404784A (en) | 2004-04-01 |
| WO2004024897A3 (en) | 2004-08-26 |
| EP1546157A2 (en) | 2005-06-29 |
| MXJL05000010A (es) | 2005-06-07 |
| RU2005109911A (ru) | 2006-04-27 |
| CN1694889A (zh) | 2005-11-09 |
| PE20050036A1 (es) | 2005-01-24 |
| US7256287B2 (en) | 2007-08-14 |
| BR0314235A (pt) | 2005-08-09 |
| TWI276631B (en) | 2007-03-21 |
| EP1546157A4 (en) | 2007-02-28 |
| PL375811A1 (en) | 2005-12-12 |
| CA2498495A1 (en) | 2004-03-25 |
| AU2003279729A1 (en) | 2004-04-30 |
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