CA2498495A1 - Phenyl-aza-benzimidazole compounds for modulating ige and inhibiting cellular proliferation - Google Patents
Phenyl-aza-benzimidazole compounds for modulating ige and inhibiting cellular proliferation Download PDFInfo
- Publication number
- CA2498495A1 CA2498495A1 CA002498495A CA2498495A CA2498495A1 CA 2498495 A1 CA2498495 A1 CA 2498495A1 CA 002498495 A CA002498495 A CA 002498495A CA 2498495 A CA2498495 A CA 2498495A CA 2498495 A1 CA2498495 A1 CA 2498495A1
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- Prior art keywords
- substituted
- alkyl
- group
- heteroaryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000004663 cell proliferation Effects 0.000 title claims abstract description 30
- 230000002401 inhibitory effect Effects 0.000 title claims description 14
- BVNWQSXXRMNYKH-UHFFFAOYSA-N 4-phenyl-2h-benzotriazole Chemical class C1=CC=CC=C1C1=CC=CC2=C1NN=N2 BVNWQSXXRMNYKH-UHFFFAOYSA-N 0.000 title abstract description 4
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 577
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- 125000001624 naphthyl group Chemical group 0.000 claims description 320
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 320
- 125000005842 heteroatom Chemical group 0.000 claims description 257
- 125000000217 alkyl group Chemical group 0.000 claims description 255
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 246
- 125000001931 aliphatic group Chemical group 0.000 claims description 195
- 125000003367 polycyclic group Chemical group 0.000 claims description 193
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 157
- 229910052757 nitrogen Inorganic materials 0.000 claims description 156
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 128
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- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims description 64
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 64
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 63
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 62
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2003/030962 WO2004024897A2 (en) | 2002-09-12 | 2003-09-12 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
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| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| DE60221804T2 (de) * | 2001-03-12 | 2008-05-15 | Avanir Pharmaceuticals, San Diego | Benzimidazolderivate zur ige-modulierung und zellproliferationshemmung |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| EP1651198A2 (en) * | 2003-08-08 | 2006-05-03 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| WO2005056547A2 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| AU2005293821B2 (en) * | 2004-10-13 | 2011-05-12 | Merck Patent Gmbh | N,N'-dithenylurea derivatives used in the form of kinase inhibitors |
| WO2006066913A2 (en) * | 2004-12-23 | 2006-06-29 | F. Hoffmann-La Roche Ag | Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors |
| CN101087786A (zh) | 2004-12-23 | 2007-12-12 | 霍夫曼-拉罗奇有限公司 | 杂环氨基甲酸酯衍生物，它们的制备及作为药剂的应用 |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| CN101208339B (zh) * | 2005-08-01 | 2010-12-29 | 霍夫曼-拉罗奇有限公司 | 杂环苄基氨基衍生物，它们的制备以及作为药剂的应用 |
| EP2064213A1 (en) | 2006-09-06 | 2009-06-03 | F. Hoffmann-La Roche AG | Heteroaryl derivatives as protein kinase inhibitors |
| CA2716951A1 (en) | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| CN105073744B (zh) | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
| GB201302927D0 (en) | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9662311B2 (en) | 2013-06-21 | 2017-05-30 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
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-
2003
- 2003-09-10 TW TW092124975A patent/TWI276631B/zh not_active IP Right Cessation
- 2003-09-12 AU AU2003279729A patent/AU2003279729A1/en not_active Abandoned
- 2003-09-12 RU RU2005109911/04A patent/RU2005109911A/ru not_active Application Discontinuation
- 2003-09-12 US US10/661,296 patent/US7256287B2/en not_active Expired - Fee Related
- 2003-09-12 CA CA002498495A patent/CA2498495A1/en not_active Abandoned
- 2003-09-12 JP JP2004536644A patent/JP2006503048A/ja not_active Withdrawn
- 2003-09-12 BR BR0314235-3A patent/BR0314235A/pt not_active IP Right Cessation
- 2003-09-12 PE PE2003000933A patent/PE20050036A1/es not_active Application Discontinuation
- 2003-09-12 WO PCT/US2003/030962 patent/WO2004024897A2/en not_active Ceased
- 2003-09-12 MX MXJL05000010A patent/MXJL05000010A/es not_active Application Discontinuation
- 2003-09-12 PL PL03375811A patent/PL375811A1/xx not_active Application Discontinuation
- 2003-09-12 AR ARP030103321A patent/AR041252A1/es not_active Application Discontinuation
- 2003-09-12 NZ NZ538547A patent/NZ538547A/en unknown
- 2003-09-12 CN CNA038250934A patent/CN1694889A/zh active Pending
- 2003-09-12 EP EP03773067A patent/EP1546157A4/en not_active Withdrawn
- 2003-09-12 KR KR1020057004331A patent/KR20050050102A/ko not_active Withdrawn
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2005
- 2005-04-05 ZA ZA200502738A patent/ZA200502738B/en unknown
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|---|---|
| MXJL05000010A (es) | 2005-06-07 |
| AU2003279729A1 (en) | 2004-04-30 |
| WO2004024897A2 (en) | 2004-03-25 |
| BR0314235A (pt) | 2005-08-09 |
| US7256287B2 (en) | 2007-08-14 |
| EP1546157A2 (en) | 2005-06-29 |
| CN1694889A (zh) | 2005-11-09 |
| TWI276631B (en) | 2007-03-21 |
| US20040116466A1 (en) | 2004-06-17 |
| WO2004024897A3 (en) | 2004-08-26 |
| EP1546157A4 (en) | 2007-02-28 |
| PE20050036A1 (es) | 2005-01-24 |
| AR041252A1 (es) | 2005-05-11 |
| NZ538547A (en) | 2007-05-31 |
| PL375811A1 (en) | 2005-12-12 |
| TW200404784A (en) | 2004-04-01 |
| ZA200502738B (en) | 2007-04-25 |
| RU2005109911A (ru) | 2006-04-27 |
| KR20050050102A (ko) | 2005-05-27 |
| JP2006503048A (ja) | 2006-01-26 |
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