KR20040083268A - 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법 - Google Patents

안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법 Download PDF

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Publication number
KR20040083268A
KR20040083268A KR1020030017867A KR20030017867A KR20040083268A KR 20040083268 A KR20040083268 A KR 20040083268A KR 1020030017867 A KR1020030017867 A KR 1020030017867A KR 20030017867 A KR20030017867 A KR 20030017867A KR 20040083268 A KR20040083268 A KR 20040083268A
Authority
KR
South Korea
Prior art keywords
peg
csf
protein
derivative
kda
Prior art date
Application number
KR1020030017867A
Other languages
English (en)
Korean (ko)
Inventor
정성엽
김영민
김경배
임창기
양근희
권세창
이관순
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to KR1020030017867A priority Critical patent/KR20040083268A/ko
Priority to PCT/KR2004/000569 priority patent/WO2004083242A1/fr
Publication of KR20040083268A publication Critical patent/KR20040083268A/ko

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Classifications

    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21J—FIBREBOARD; MANUFACTURE OF ARTICLES FROM CELLULOSIC FIBROUS SUSPENSIONS OR FROM PAPIER-MACHE
    • D21J3/00—Manufacture of articles by pressing wet fibre pulp, or papier-mâché, between moulds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B3/00—Presses characterised by the use of rotary pressing members, e.g. rollers, rings, discs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B9/00—Presses specially adapted for particular purposes
    • B30B9/28—Presses specially adapted for particular purposes for forming shaped articles
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B1/00—Manually or mechanically operated educational appliances using elements forming, or bearing, symbols, signs, pictures, or the like which are arranged or adapted to be arranged in one or more particular ways
    • G09B1/32—Manually or mechanically operated educational appliances using elements forming, or bearing, symbols, signs, pictures, or the like which are arranged or adapted to be arranged in one or more particular ways comprising elements to be used without a special support
    • G09B1/36—Manually or mechanically operated educational appliances using elements forming, or bearing, symbols, signs, pictures, or the like which are arranged or adapted to be arranged in one or more particular ways comprising elements to be used without a special support the elements being connectible by corresponding projections and recesses

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Educational Technology (AREA)
  • Toxicology (AREA)
  • Educational Administration (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Business, Economics & Management (AREA)
  • Manufacturing & Machinery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020030017867A 2003-03-21 2003-03-21 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법 KR20040083268A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020030017867A KR20040083268A (ko) 2003-03-21 2003-03-21 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법
PCT/KR2004/000569 WO2004083242A1 (fr) 2003-03-21 2004-03-17 Conjugue de facteur stimulant les colonies de granulocytes humain presentant une stabilite accrue dans le sang et son procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020030017867A KR20040083268A (ko) 2003-03-21 2003-03-21 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법

Publications (1)

Publication Number Publication Date
KR20040083268A true KR20040083268A (ko) 2004-10-01

Family

ID=33028844

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020030017867A KR20040083268A (ko) 2003-03-21 2003-03-21 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법

Country Status (2)

Country Link
KR (1) KR20040083268A (fr)
WO (1) WO2004083242A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047334A1 (fr) 2003-11-13 2005-05-26 Hanmi Pharmaceutical. Co., Ltd. Fragment d'igg fc pour vecteur de medicament et procede de preparation associe
KR100735784B1 (ko) * 2005-07-20 2007-07-06 재단법인 목암생명공학연구소 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094530A1 (fr) * 2005-03-11 2006-09-14 Siegfried Ltd. Conjugues de proteines et de dipolymeres et leurs procedes de preparation
EP1834963A1 (fr) * 2006-03-13 2007-09-19 Siegfried Ltd. Conjugues de proteines et de dipolymeres et leurs procedes de preparation
KR101079993B1 (ko) 2006-11-17 2011-11-04 동아제약주식회사 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
RU2446173C1 (ru) * 2010-08-13 2012-03-27 Зао "Биокад" Новый функционально активный, высокоочищенный стабильный конъюгат гранулоцитарного колониестимулирующего фактора (г-ксф) с полиэтиленгликолем с пролонгированным биологическим действием, пригодный для медицинского применения, и иммунобиологическое средство на его основе
CN102485742A (zh) * 2010-12-02 2012-06-06 山东新时代药业有限公司 一种聚乙二醇单修饰的重组人粒细胞集落刺激因子的制备及分离纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE135370T1 (de) * 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
KR100480432B1 (ko) * 2001-12-04 2005-04-06 선바이오(주) Ｇ-ｃｓｆ와 폴리에틸렌글리콜 유도체의 배합체

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047334A1 (fr) 2003-11-13 2005-05-26 Hanmi Pharmaceutical. Co., Ltd. Fragment d'igg fc pour vecteur de medicament et procede de preparation associe
EP2239273A1 (fr) 2003-11-13 2010-10-13 Hanmi Pharmaceutical. Co., Ltd. Composition pharmaceutique comportant une immunoglobuline Fc en tant que support
EP2256134A1 (fr) 2003-11-13 2010-12-01 Hanmi Pharmaceutical Co., Ltd. Fragment d'IgG Fc pour vecteur de médicament et procédé de préparation associé
KR100735784B1 (ko) * 2005-07-20 2007-07-06 재단법인 목암생명공학연구소 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물

Also Published As

Publication number Publication date
WO2004083242A1 (fr) 2004-09-30

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