KR20040081716A - Composition comprising an extract of astragalusmembranaceus for hair growing promotor - Google Patents

Abstract

PURPOSE: A hair growth promoting agent containing, as an effective component, an Astragali Radix extract exhibiting excellent hair growth promoting action as compared to minoxidil is provided. It can be used as a hair growth promoting agent without causing adverse side effects to the human body. CONSTITUTION: The hair growth promoting agent contains an Astragali Radix extract and a pharmaceutically acceptable carrier. It additionally contains an herbal extract selected from Thuja orientalis, Morus alba, Sophorae Radix, Glycyrrhizae Radix, Caryophylli Flos, Flos Carthami, Fructus Aurantii Immaturus, Theae folium and dried eggplants. The hair growth promoting agent is formulated into shampoos, soaps, creams or the like and its dosage is about 2 and 20mg (preferably 6 to 10mg) per kg body weight per day.

Description

Hair growth promoting agent containing Astragalus extract as an active ingredient {COMPOSITION COMPRISING AN EXTRACT OF ASTRAGALUSMEMBRANACEUS FOR HAIR GROWING PROMOTOR}

The present invention relates to a hair growth promoter containing the extract of Astragalus membranaceus Bunge as an active ingredient and a method for producing the same.

The human hair has about 100,000 to 150,000 hairs, and each hair has a different hair cycle, and the hair is produced, grown, and dropped by repeating the anagen, the catagen, and the telogen. About 15% of the hair is placed in the resting and retirement stages, so that on average 50-100 hairs fall out and reproduce normally. The hair growth cycle is called hair growth, and the hair cycle repeats about 3 to 6 years.

In general, alopecia refers to a period in which the growth period of the hair cycle is shortened due to various causes, so that the ratio of degenerative and resting hair increases relatively, so that the number of hair dropouts is higher than the average value. The theory of the action of red androgen hormones, nutritional disorders caused by local blood flow disorders, autonomic disorders, autoimmune disorders, endocrine disorders, but until now the specific cause of hair loss is not known. It is known to occur. In recent years, the population that causes abnormal hair loss due to changes in diet, lifestyle changes, and excessive stress caused by social environment is gradually increasing. Especially, the hair loss population of the young, middle-aged and female is increasing.

Minoxidil of Upjohn Co., Ltd. disclosed in U.S. Patent No. 4,596,812, which is being used to promote hair growth, is currently used as an antihypertensive agent. It is a mechanism that promotes hair growth by increasing the blood flow of the scalp where the hair follicles are located, focusing on the increase of human hair. However, when minoxidil is used as a hair growth promoter for a long time, the effect is halved and chemical vasodilation effect is achieved. As a result of side effects, lethargy, sebum increase, etc. have been reported.

Accordingly, the present inventors have studied for a safe natural hair growth promoting agent having sufficient hair growth promoting effect, the blood pressure lowering action of Astragalus membranaceus Bunge, a natural plant of nature, strengthens the immune function of the liquid and binds to the human estrogen receptor Long-term clinical and research results on hair growth promoter using Astragalus extract were noted for their active action; The present invention was completed by confirming the safe and excellent hair growth promoting effect of Astragalus membranaceus Bunge extract.

Table 1, Production Examples of Hair Growth Promoters According to the Present Invention

Table 2, Example hair growth promoter according to the present invention

1, 3, 5, 7, 7, 9,

Photograph before use of hair growth promoter according to the present invention

2, 4, 6, 8, 10,

Picture after using hair growth promoter according to the present invention

The present invention identifies a new fact that Astragalus membranaceus Bunge extract has a hair growth promoting effect, and relates to a hair growth promoter containing the extract as an active ingredient and a method for producing the same.

Astragalus membranaceus Bunge is a perennial herb belonging to the legume (Leguminosae), which grows mainly in mountains and highlands, but is recently cultivated in various places. His herbal name is Astragali Radix and its root is used as a medicinal herb. It is known to have the effects of turbid poison, etc., and has a therapeutic effect on internal wounds and all ischemia. Major pharmacological efficacy studies have been reported to lower blood pressure, cardiac action, hepatoprotective action, hypoglycemic action. The main components of Astragalus are triterpenoide glocoside and flavo-noid. Especially, the fraction of Astragalus butane is known to contain soyasaponin and astragalo-sides.

Hereinafter, the present invention will be described in detail.

The Astragalus membranaceus Bunge extract of the present invention can be extracted from the dried Astragalus root by using a water or a lower alcohol in a conventional manner. More effectively, Astragali Radix has a weight ratio of 3 to 20 times the carbon number 1 Lower alcohols (methanol, ethanol, butanol, propanol, etc.) to 4 are added, followed by extraction with heating and stirring. The extract is distilled under reduced pressure to remove the solvent to fractionate the solid extract.

The hair growth promoter composition containing the extract of Astragalus of the present invention, when used for the purpose of hair growth, is preferably used for oral administration such as conventional preparations (liquids, suspensions, capsules, tablets) according to pharmaceutical methods, solutions for injection. Or a variety of topical applications such as injectable preparations, ointments, creams, lotions, liquids, sprays, etc., in the form of suspensions or ready-to-use dry powders that can be reconstituted with injectable distilled water at the time of injection. It can be used as a formulation.

Carriers that can be used for the formulation of the invention are conventional in the pharmaceutical art, for example in the case of oral preparations binders, suspending agents, disintegrating agents, excipients, solubilizing agents, dispersants, stabilizers, suspending agents , Pigments, flavorings, and the like. In the case of injections, there are preservatives, analgesic agents, solubilizers, stabilizers, and the like. In the case of topical administration, there are bases, excipients, lubricants, preservatives, propellants, and the like. The pharmaceutical preparations thus prepared may be administered orally or parenterally, for example, intravenously, subcutaneously, intraperitoneally, or topically.

The hair growth promoting agent composition of the present invention is preferably formulated into topical application preparations, such as ointments, lotions, sprays, and the like, and applied directly to the hair loss site. The hair growth promoter composition of the present invention may also include one or more additional herbal ingredients that may enhance the hair growth effect as needed. Herbal ingredients that can be included for this purpose include, for example, baekbaek, baekbaek, ginseng, licorice, cloves, safflower, dermis, cheongho, green tea, dried branches, dermis, and the like. When such additional herbal ingredients are included in the composition of the present invention, their content is preferably within 5% based on the total weight of the composition.

In addition, the hair growth promoting composition of the present invention includes an antibacterial hair composition and a skin composition. The hair growth promoting composition includes hinokithiol, pepper tink, tocopherol acetate, nicotinamide benzine, pyrotonolamine, salicylic acid, L-menthol, and the like, which are conventional compounding ingredients, and include shampoo, hair conditioner, hair lotion, and liquid. All formulations that can be applied to the scalp, such as hair growth promoter type, are possible. The skin composition includes alpha hydroxy acid (a-Hydroxy acid), beta hydroxy acid (B-Hydroxy acid), fragrances, pigments, fungicides, antioxidants, preservatives, humectants and the like, shampoo, soap as a cosmetic or cleaning agent Formulations such as creams are possible.

The application amount of the composition according to the present invention is appropriately selected according to the type of alopecia and the condition of the alopecia, but is generally administered in an amount of 2 to 20 mg per kg body weight, preferably 6 to 10 mg per day for normal normal adults .

The present invention is described in more detail by the following examples and experimental examples, but the present invention is not limited in any way by these.

<Production example 1>

Astragalus Extract

After washing and drying 1kg commercial Astragalus, dry it in 80% MeOH 5L, and leave it in the dark for 48 hours. After filtrating three times, the filtrate was collected and used under reduced pressure concentrator (Buchi Co. R-114, Germany). Concentrated to give 164.5g of extract using a freeze dryer.

In accordance with a conventional liquid hair growth promoter manufacturing method was prepared a hair growth promoter containing a sulfur extract of the ratio shown in Table 1.

<Example 1>

As the animal for the hair growth experiment, a mouse (C57BL / 6) weighing 23 to 28 g of body weight of 45 to 53 days of age was used, and the test substance for each test group (10) was prepared in Preparation Examples 1 to 3 and Comparative Examples 1 to 2 Was applied.

Hair removal treatment was performed using a hair clipper (Clipper, Oster # 40) and an electric shaver on the back of a mouse (C57BL / 6) weighing 45 to 53 days of age. From the day after hair removal, the respective test substances were applied to the mouse hair removal skin of each group in an amount of 2 ml per day for 16 days, and the simulated growth over time for 17 days from the first treatment day. The extent was searched by recording the hair growth score. The hair growth score was determined by the total hair loss state as 0, the hair follicles completely restored to 3, and subdivided into 0.5 units by measuring the length and area of hair follicles in accordance with the hair restoration noon and the restoration area.

As can be seen from the results described in Table 1, the Astragalus extract according to the present invention showed a better hair growth promoting effect than the minoxidil, a conventional hair regrowth agent. From these results, it was confirmed that the Astragalus extract according to the present invention can be used as an excellent hair promoter.

Claims (4)

Hair growth accelerator composition containing astragalus extract as an active ingredient. The hair growth promoter according to claim 1, which is prepared in a pharmaceutical formulation using a pharmaceutically acceptable carrier. The hair growth promoter according to claim 1, further comprising a herbal ingredient selected from white, white, red ginseng, licorice, cloves, safflower, dermis, cheongho, green tea, dried branches, and dermis. The hair growth promoting agent according to claim 1, which is a cosmetic or cleaning agent in a formulation such as shampoo, soap, cream, and the like.