KR20040077883A - 유기 화합물의 제조 방법 - Google Patents

유기 화합물의 제조 방법 Download PDF

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Publication number
KR20040077883A
KR20040077883A KR10-2004-7011572A KR20047011572A KR20040077883A KR 20040077883 A KR20040077883 A KR 20040077883A KR 20047011572 A KR20047011572 A KR 20047011572A KR 20040077883 A KR20040077883 A KR 20040077883A
Authority
KR
South Korea
Prior art keywords
formula
hydroxy
lower alkyl
aralkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2004-7011572A
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English (en)
Korean (ko)
Inventor
광-페이 첸
프라사드 코테스와라 카파
에릭 엠. 로서
울리치 보이틀러
베르너 차우크
마이클 제이. 기르기스
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20040077883A publication Critical patent/KR20040077883A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
  • Quinoline Compounds (AREA)
KR10-2004-7011572A 2002-01-28 2003-01-27 유기 화합물의 제조 방법 Ceased KR20040077883A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35231602P 2002-01-28 2002-01-28
US60/352,316 2002-01-28
US38318802P 2002-05-24 2002-05-24
US60/383,188 2002-05-24
PCT/EP2003/000804 WO2003064382A2 (en) 2002-01-28 2003-01-27 Process for the manufacture of organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020107017248A Division KR20100091267A (ko) 2002-01-28 2003-01-27 유기 화합물의 제조 방법

Publications (1)

Publication Number Publication Date
KR20040077883A true KR20040077883A (ko) 2004-09-07

Family

ID=27669055

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-2004-7011572A Ceased KR20040077883A (ko) 2002-01-28 2003-01-27 유기 화합물의 제조 방법
KR1020107017248A Ceased KR20100091267A (ko) 2002-01-28 2003-01-27 유기 화합물의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020107017248A Ceased KR20100091267A (ko) 2002-01-28 2003-01-27 유기 화합물의 제조 방법

Country Status (19)

Country Link
US (3) US6835838B2 (https=)
EP (1) EP1472227B1 (https=)
JP (1) JP2005516064A (https=)
KR (2) KR20040077883A (https=)
CN (2) CN100378081C (https=)
AU (4) AU2003239294B2 (https=)
BR (1) BR0307236A (https=)
CA (1) CA2472340A1 (https=)
CO (1) CO5601045A2 (https=)
EC (1) ECSP045202A (https=)
IL (1) IL162817A0 (https=)
MX (1) MXPA04007308A (https=)
NO (1) NO327363B1 (https=)
NZ (3) NZ554366A (https=)
PL (1) PL371383A1 (https=)
RU (1) RU2360903C2 (https=)
SG (2) SG161742A1 (https=)
WO (1) WO2003064382A2 (https=)
ZA (1) ZA200405239B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04000322A (es) 2001-07-13 2005-09-08 Astrazeneca Uk Ltd Preparacion de compuestos de aminopirimidina.
KR100919941B1 (ko) 2001-11-14 2009-10-05 닛산 가가쿠 고교 가부시키 가이샤 광학활성 옥소헵텐산 에스테르의 제조방법
PL370658A1 (en) * 2002-01-31 2005-05-30 Novartis Ag Process for the manufacture of hmg-coa reductase inhibitors
US7339062B2 (en) * 2002-09-20 2008-03-04 Nissan Chemical Industries, Ltd. Method for producing a 3,5-dihydroxy-6-heptenoate
CN101219992B (zh) * 2003-02-12 2011-08-31 日产化学工业株式会社 匹伐他汀钙的晶形
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
CN1763015B (zh) * 2004-10-22 2011-06-22 四川抗菌素工业研究所有限公司 一种罗舒伐他汀及其药用盐的制备方法及中间体
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
EP2024341B1 (en) * 2006-05-03 2015-12-02 MSN Laboratories Private Limited Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) * 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2010089770A2 (en) * 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
RU2425034C1 (ru) * 2010-01-11 2011-07-27 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") Способ получения производных (e)-4-(6,7-диметокси-2-метил-3-хинолил)-3-бутен-2-она
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
EP2423195A1 (en) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
JP2013536219A (ja) * 2010-08-25 2013-09-19 カディラ・ヘルスケア・リミテッド ピタバスタチンカルシウムおよびその調製方法
EP3178812A1 (en) * 2010-11-12 2017-06-14 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
WO2012140490A2 (en) 2011-04-11 2012-10-18 Aurobindo Pharma Limited Process for preparing quinoline derivative
CN103755568B (zh) * 2013-12-10 2015-10-28 江西科技师范大学 IeodomycinA和B立体选择性合成方法
US10676441B2 (en) 2015-08-05 2020-06-09 Api Corporation Method for producing pitavastatin calcium
CN108976168B (zh) * 2017-06-02 2020-09-25 浙江京新药业股份有限公司 一种匹伐他汀半钙盐晶型及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3130342B2 (ja) * 1991-10-04 2001-01-31 日産化学工業株式会社 動脈硬化性血管内膜肥厚抑制薬
JP3554036B2 (ja) * 1994-09-06 2004-08-11 宇部興産株式会社 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
KR100919941B1 (ko) * 2001-11-14 2009-10-05 닛산 가가쿠 고교 가부시키 가이샤 광학활성 옥소헵텐산 에스테르의 제조방법
WO2008096257A1 (en) * 2007-02-08 2008-08-14 Aurobindo Pharma Limited An improved process for preparation of rosuvastatin calcium

Also Published As

Publication number Publication date
NZ554366A (en) 2008-11-28
US6835838B2 (en) 2004-12-28
NZ554367A (en) 2008-11-28
AU2006225206B2 (en) 2009-08-06
PL371383A1 (en) 2005-06-13
US7572917B2 (en) 2009-08-11
ZA200405239B (en) 2005-07-27
AU2003239294B2 (en) 2006-10-19
US20090299065A1 (en) 2009-12-03
NO327363B1 (no) 2009-06-15
EP1472227B1 (en) 2016-04-27
MXPA04007308A (es) 2004-10-29
KR20100091267A (ko) 2010-08-18
CN1660818A (zh) 2005-08-31
RU2360903C2 (ru) 2009-07-10
IL162817A0 (en) 2005-11-20
AU2009208129A1 (en) 2009-09-03
NZ534136A (en) 2007-08-31
US20030208072A1 (en) 2003-11-06
JP2005516064A (ja) 2005-06-02
US20040249154A1 (en) 2004-12-09
AU2006225205A1 (en) 2006-10-26
RU2004126448A (ru) 2005-06-27
EP1472227A2 (en) 2004-11-03
CA2472340A1 (en) 2003-08-07
CO5601045A2 (es) 2006-01-31
AU2006225206A1 (en) 2006-10-26
WO2003064382A2 (en) 2003-08-07
NO20043586L (no) 2004-10-07
SG157225A1 (en) 2009-12-29
AU2006225205B2 (en) 2009-08-06
CN1625550A (zh) 2005-06-08
ECSP045202A (es) 2004-09-28
SG161742A1 (en) 2010-06-29
WO2003064382A3 (en) 2003-12-11
CN100378081C (zh) 2008-04-02
BR0307236A (pt) 2004-12-07

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