KR20030063472A - 항 박테리아 활성을 갖는 신규의 헤테로고리 화합물, 그제조방법 및 이들을 포함하는 약제학적 조성물 - Google Patents

항 박테리아 활성을 갖는 신규의 헤테로고리 화합물, 그제조방법 및 이들을 포함하는 약제학적 조성물 Download PDF

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Publication number
KR20030063472A
KR20030063472A KR10-2003-7008637A KR20037008637A KR20030063472A KR 20030063472 A KR20030063472 A KR 20030063472A KR 20037008637 A KR20037008637 A KR 20037008637A KR 20030063472 A KR20030063472 A KR 20030063472A
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KR
South Korea
Prior art keywords
alkyl
oxo
phenyl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR10-2003-7008637A
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English (en)
Korean (ko)
Inventor
셀바쿠말 나테산
자가타란 다스
자베드 아이크발
시타람 쿠말 마가디
나가 벤카타 스리니바자 라오 마미디
라자고팔란 라마누잠
바스카란 순다라바부
브라이 부샨 로레이
Original Assignee
닥터 레디스 리서치 파운데이숀
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Application filed by 닥터 레디스 리서치 파운데이숀 filed Critical 닥터 레디스 리서치 파운데이숀
Publication of KR20030063472A publication Critical patent/KR20030063472A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR10-2003-7008637A 2000-12-26 2001-12-26 항 박테리아 활성을 갖는 신규의 헤테로고리 화합물, 그제조방법 및 이들을 포함하는 약제학적 조성물 Ceased KR20030063472A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1124/MAS/2000 2000-12-26
IN1124MA2000 2000-12-26
IN15MA2001 2001-01-15
IN15/MAS/2001 2001-01-15
PCT/IN2001/000227 WO2002051819A2 (en) 2000-12-26 2001-12-26 Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
KR20030063472A true KR20030063472A (ko) 2003-07-28

Family

ID=26324889

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7008637A Ceased KR20030063472A (ko) 2000-12-26 2001-12-26 항 박테리아 활성을 갖는 신규의 헤테로고리 화합물, 그제조방법 및 이들을 포함하는 약제학적 조성물

Country Status (21)

Country Link
US (2) US7030148B2 (https=)
EP (1) EP1345913A2 (https=)
JP (1) JP2004525876A (https=)
KR (1) KR20030063472A (https=)
CN (1) CN1656083A (https=)
BG (1) BG108022A (https=)
BR (1) BR0116571A (https=)
CA (1) CA2433138A1 (https=)
CZ (1) CZ20031799A3 (https=)
EE (1) EE200300254A (https=)
HR (1) HRP20030522A2 (https=)
HU (1) HUP0302580A2 (https=)
IL (1) IL156662A0 (https=)
MX (1) MXPA03005822A (https=)
NO (1) NO20032926L (https=)
NZ (1) NZ526716A (https=)
PL (1) PL363616A1 (https=)
RU (1) RU2322444C2 (https=)
SK (1) SK8202003A3 (https=)
WO (1) WO2002051819A2 (https=)
YU (1) YU52403A (https=)

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US7396847B2 (en) 2001-09-11 2008-07-08 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
US20060293315A1 (en) * 2001-12-21 2006-12-28 Dr. Reddy's Laboratories Ltd. Intermediates of novel heterocyclic compounds having antibacterial activity and process for their preparation
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
DE10233817A1 (de) * 2002-07-25 2004-02-12 Aventis Pharma Deutschland Gmbh Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7141561B2 (en) 2002-07-25 2006-11-28 Sanofi-Aventis Deutschland Gmbh Substituted diaryl heterocycles, process for their preparation and their use as medicaments
US20080214565A1 (en) * 2003-04-07 2008-09-04 Anita Mehta Oxazolidinone Derivatives as Antimicrobials
DE602004027811D1 (de) 2003-07-02 2010-08-05 Kyorin Seiyaku Kk Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
EP1654259A1 (en) * 2003-07-02 2006-05-10 Merck & Co., Inc. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
WO2005035528A2 (en) * 2003-10-14 2005-04-21 Dr. Reddy's Laboratories Ltd. Triazole derivatives as antibacterial agents
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1866295A2 (en) * 2005-02-24 2007-12-19 Teva Pharmaceutical Industries Ltd Processes for the preparation of linezolid intermediate
ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
US8178683B2 (en) * 2007-08-06 2012-05-15 Micurx Pharmaceuticals, Inc. Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
PE20110368A1 (es) * 2008-08-18 2011-06-13 Univ Yale Moduladores de mif
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
KR101918678B1 (ko) 2009-02-03 2018-11-14 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
CN101798302B (zh) * 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
WO2014045292A1 (en) * 2012-09-20 2014-03-27 Symed Labs Limited Improved process for the preparation of linezolid intermediate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN105612166B (zh) 2014-02-21 2019-02-19 上海盟科药业有限公司 治疗用水溶性(o-羰基)氨基磷酸酯前药
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
US12109203B2 (en) 2018-07-25 2024-10-08 Zydus Lifesciences Limited Substituted oxazolidinones for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections
CN110301433A (zh) * 2019-07-25 2019-10-08 河南精怡达生物科技有限公司 一种含有微量元素组合的猪精液体外常温保存剂

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Also Published As

Publication number Publication date
CN1656083A (zh) 2005-08-17
CZ20031799A3 (cs) 2004-02-18
BG108022A (bg) 2004-09-30
NO20032926L (no) 2003-08-25
BR0116571A (pt) 2004-03-02
EP1345913A2 (en) 2003-09-24
WO2002051819A9 (en) 2003-08-07
CA2433138A1 (en) 2002-07-04
EE200300254A (et) 2003-12-15
RU2003123104A (ru) 2005-03-10
SK8202003A3 (en) 2004-07-07
RU2322444C2 (ru) 2008-04-20
US20040059120A1 (en) 2004-03-25
PL363616A1 (en) 2004-11-29
NO20032926D0 (no) 2003-06-25
JP2004525876A (ja) 2004-08-26
HRP20030522A2 (en) 2005-06-30
US7183301B2 (en) 2007-02-27
US20030065175A1 (en) 2003-04-03
IL156662A0 (en) 2004-01-04
US7030148B2 (en) 2006-04-18
MXPA03005822A (es) 2004-05-04
YU52403A (sh) 2006-03-03
HUP0302580A2 (hu) 2003-11-28
NZ526716A (en) 2005-08-26
WO2002051819A3 (en) 2002-12-05
WO2002051819A2 (en) 2002-07-04

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