KR20020038713A - 클린다마이신 질 좌약 조성물 - Google Patents
클린다마이신 질 좌약 조성물 Download PDFInfo
- Publication number
- KR20020038713A KR20020038713A KR1020027001576A KR20027001576A KR20020038713A KR 20020038713 A KR20020038713 A KR 20020038713A KR 1020027001576 A KR1020027001576 A KR 1020027001576A KR 20027001576 A KR20027001576 A KR 20027001576A KR 20020038713 A KR20020038713 A KR 20020038713A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- clindamycin
- ester
- salt
- suppository
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
클린다마이신 포스페이트 질 좌약 조성물 | |
좌약 당 함량 | 성분 |
100 mg1 | 클린다마이신 포스페이트 USP (분쇄됨) |
2,375 mg | Witepsol H-32 (경지방 NF) |
(1) 유리 염기로 환산하여 나타냄. 사용된 클린다마이신 포스페이트의 실제량은효능 분석 (예를 들어, USP)을 기초로 계산함. |
Claims (12)
- 경지방 좌약 기제 중에 분산된 항미생물 유효량의 클린다마이신, 그의 제약상 허용되는 염 또는 에스테르를 함유하는, 질내 투여용 클린다마이신 좌약 조성물.
- 제1항에 있어서, 클린다마이신, 그의 염 또는 에스테르를 그의 유리 염기를 기준으로 10 내지 800 mg 함유하는 조성물로, 상기 클린다마이신, 그의 염 또는 에스테르는 상기 조성물 중에 총 조성물의 약 0.1 중량% 내지 약 60 중량%의 양으로 존재하는 것인 조성물.
- 제2항에 있어서, 상기 경지방이 30 ℃ 내지 40 ℃ 범위의 유동점을 갖는 β다형체 형태인 조성물.
- 제3항에 있어서, 클린다마이신, 그의 염 또는 에스테르를 그의 유리 염기를 기준으로 25 내지 300 mg 함유하는 조성물로, 상기 클린다마이신, 그의 염 또는 에스테르는 상기 조성물 중에 총 조성물의 약 0.5 중량% 내지 약 30 중량%의 양으로 존재하는 것인 조성물.
- 제4항에 있어서, 상기 경지방이 37 ℃ 이하의 유동점을 갖는 β다형체 형태인 조성물.
- 제5항에 있어서, 경지방이 트리글리세라이드 에스테르를 50 % 이상 함유하는, 식물성 C12-C18포화 지방산의 글리세라이드 에스테르 혼합물인 조성물.
- 제6항에 있어서, 클린다마이신, 그의 염 또는 에스테르를 그의 유리 염기를 기준으로 50 내지 200 mg 함유하는 조성물로, 상기 클린다마이신, 그의 염 또는 에스테르는 상기 조성물 중에 총 조성물의 약 1.5 중량% 내지 약 10 중량%의 양으로 존재하는 것인 조성물.
- 제7항에 있어서, 클린다마이신이 클린다마이신의 염 또는 에스테르인 조성물.
- 제8항에 있어서, 클린다마이신의 입자 크기가 10 ㎛ 이하인 조성물.
- 제9항에 있어서, 클린다마이신의 염 또는 에스테르를 그의 유리 염기를 기준으로 50 내지 150 mg 함유하는 조성물로, 상기 클린다마이신의 염 또는 에스테르는 상기 조성물 중에 총 조성물의 약 1.5 중량% 내지 약 7.5 중량%의 양으로 존재하는 것인 조성물.
- 제10항에 있어서, 클린다마이신이 클린다마이신 포스페이트인 조성물.
- 제1항에 있어서, 경지방이 하기의 추가 특징을 갖는 NF 등급 경지방인 조성물.오픈-튜브 융점: 31.0 - 33.0 ℃ (α다형체 형태)고화점: 30.0 - 32.5 ℃ (α다형체 형태)히드록실 값: 1 g 당 수산화칼륨 최대 3 mg비누화 값: 1 g 당 수산화칼륨 240 - 250 mg디글리세라이드: 최대 15 중량%모노글리세라이드: 최대 1 중량%
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14756199P | 1999-08-06 | 1999-08-06 | |
US60/147,561 | 1999-08-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20020038713A true KR20020038713A (ko) | 2002-05-23 |
KR100670085B1 KR100670085B1 (ko) | 2007-01-17 |
Family
ID=22522061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027001576A KR100670085B1 (ko) | 1999-08-06 | 2000-07-20 | 클린다마이신 질 좌약 조성물 |
Country Status (24)
Country | Link |
---|---|
US (2) | US6495157B1 (ko) |
EP (1) | EP1200065B1 (ko) |
JP (1) | JP2003519095A (ko) |
KR (1) | KR100670085B1 (ko) |
CN (1) | CN1160056C (ko) |
AR (1) | AR025045A1 (ko) |
AT (1) | ATE250408T1 (ko) |
AU (1) | AU768907B2 (ko) |
CA (1) | CA2378572A1 (ko) |
DE (1) | DE60005524T2 (ko) |
DK (1) | DK1200065T3 (ko) |
ES (1) | ES2207532T3 (ko) |
HK (1) | HK1047538A1 (ko) |
HN (1) | HN2000000166A (ko) |
MA (1) | MA26749A1 (ko) |
MX (1) | MXPA02001320A (ko) |
NZ (1) | NZ517039A (ko) |
PA (1) | PA8499101A1 (ko) |
PE (1) | PE20010484A1 (ko) |
PT (1) | PT1200065E (ko) |
SI (1) | SI1200065T1 (ko) |
SV (1) | SV2001000138A (ko) |
TW (1) | TWI232111B (ko) |
WO (1) | WO2001010407A1 (ko) |
Families Citing this family (35)
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TWI232111B (en) * | 1999-08-06 | 2005-05-11 | Upjohn Co | Intravaginal clindamycin ovule composition |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
WO2004014338A1 (en) * | 2002-02-05 | 2004-02-19 | Pharmacia & Upjohn Company | Composition and method for rectal delivery of a lincosamide antibacterial drug |
GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
EP1648407A4 (en) | 2003-07-21 | 2011-08-31 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION |
WO2005009364A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
JP2006528189A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
EP1653925A1 (en) | 2003-08-11 | 2006-05-10 | Advancis Pharmaceutical Corporation | Robust pellet |
JP2007502294A (ja) | 2003-08-12 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
EP1658034A4 (en) | 2003-08-29 | 2011-06-22 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
CA2538064C (en) | 2003-09-15 | 2013-12-17 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
US20060140990A1 (en) * | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
BRPI0414500A (pt) * | 2003-09-19 | 2006-11-07 | Drugtech Corp | formulação farmacêutica composição para tratar uma infecção vaginal, e, métodos para tratar uma infecção vaginal, para estabilizar uma formulação de clindamicina, para tratar ou prevenir uma recorrência de uma infecção vaginal em uma paciente e para tratar condições vaginais |
US20070065504A1 (en) * | 2004-03-23 | 2007-03-22 | Lin Shun Y | Products and methods for treating vaginal infections |
US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
WO2006014427A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
US20060078616A1 (en) * | 2004-08-30 | 2006-04-13 | Georgewill Dawaye A | Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
AU2006244260A1 (en) * | 2005-05-09 | 2006-11-16 | Drugtech Corporation | Modified-release pharmaceutical compositions |
CN100446774C (zh) * | 2005-05-31 | 2008-12-31 | 黑龙江龙桂制药有限公司 | 盐酸克林霉素阴道泡腾片及其制备方法 |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
EA200870153A1 (ru) * | 2006-01-05 | 2008-12-30 | Драгтек Корпорейшн | Композиция и способ ее использования |
CA2635994A1 (en) * | 2006-01-05 | 2007-07-12 | Drugtech Corporation | Drug delivery system for bioadhesion to a vulvovaginal surface |
US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
DE102009055644A1 (de) * | 2009-11-25 | 2011-06-01 | Nicole Nedela | Dildo-Set |
CN103735491B (zh) * | 2013-12-31 | 2016-01-13 | 哈尔滨欧替药业有限公司 | 克林霉素磷酸酯阴道膨胀栓及其制备方法和检测方法 |
US10751299B2 (en) | 2018-09-04 | 2020-08-25 | Babak Ghalili | Cannabinoid and menthol compositions and methods |
US10813963B2 (en) | 2018-09-04 | 2020-10-27 | Babak Ghalili | Veterinary cannabinoid and menthol compositions and methods |
WO2021177938A1 (en) * | 2020-03-02 | 2021-09-10 | Babak Ghalili | Veterinary cannabinoid and menthol compositions and methods |
MX2020011523A (es) * | 2020-10-29 | 2022-05-02 | Exeltis Pharma Mexico S A De C V | Composicion farmaceutica adecuada para administracion vaginal en forma de ovulos y uso de la misma. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2812683B2 (ja) * | 1988-07-26 | 1998-10-22 | 富士製薬工業株式会社 | 持続性を有するモルヒネ直腸投与製剤 |
JPH05213752A (ja) * | 1992-02-06 | 1993-08-24 | Fujisawa Asutora Kk | 坐 剤 |
GB9610359D0 (en) * | 1996-05-17 | 1996-07-24 | Edko Trading Representation | Pharmaceutical compositions |
DE19737348C2 (de) * | 1997-08-27 | 2002-07-25 | Dan-Gabriel Vulpescu | Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung |
TWI232111B (en) * | 1999-08-06 | 2005-05-11 | Upjohn Co | Intravaginal clindamycin ovule composition |
-
2000
- 2000-07-17 TW TW089114267A patent/TWI232111B/zh not_active IP Right Cessation
- 2000-07-20 CA CA002378572A patent/CA2378572A1/en not_active Abandoned
- 2000-07-20 MX MXPA02001320A patent/MXPA02001320A/es active IP Right Grant
- 2000-07-20 NZ NZ517039A patent/NZ517039A/xx not_active IP Right Cessation
- 2000-07-20 WO PCT/US2000/019533 patent/WO2001010407A1/en active IP Right Grant
- 2000-07-20 PT PT00948739T patent/PT1200065E/pt unknown
- 2000-07-20 EP EP00948739A patent/EP1200065B1/en not_active Expired - Lifetime
- 2000-07-20 JP JP2001514928A patent/JP2003519095A/ja active Pending
- 2000-07-20 DK DK00948739T patent/DK1200065T3/da active
- 2000-07-20 AU AU62198/00A patent/AU768907B2/en not_active Expired
- 2000-07-20 US US09/619,930 patent/US6495157B1/en not_active Expired - Lifetime
- 2000-07-20 ES ES00948739T patent/ES2207532T3/es not_active Expired - Lifetime
- 2000-07-20 AT AT00948739T patent/ATE250408T1/de active
- 2000-07-20 DE DE60005524T patent/DE60005524T2/de not_active Expired - Lifetime
- 2000-07-20 SI SI200030275T patent/SI1200065T1/xx unknown
- 2000-07-20 KR KR1020027001576A patent/KR100670085B1/ko active IP Right Grant
- 2000-07-20 CN CNB008102031A patent/CN1160056C/zh not_active Expired - Lifetime
- 2000-08-02 HN HN2000000166A patent/HN2000000166A/es unknown
- 2000-08-04 MA MA26034A patent/MA26749A1/fr unknown
- 2000-08-04 PA PA20008499101A patent/PA8499101A1/es unknown
- 2000-08-04 PE PE2000000779A patent/PE20010484A1/es not_active IP Right Cessation
- 2000-08-04 AR ARP000104042A patent/AR025045A1/es not_active Application Discontinuation
- 2000-08-07 SV SV2000000138A patent/SV2001000138A/es active IP Right Grant
-
2002
- 2002-02-05 US US10/072,492 patent/US20020197320A1/en not_active Abandoned
- 2002-11-29 HK HK02108642A patent/HK1047538A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6495157B1 (en) | 2002-12-17 |
JP2003519095A (ja) | 2003-06-17 |
AU768907B2 (en) | 2004-01-08 |
EP1200065B1 (en) | 2003-09-24 |
SV2001000138A (es) | 2001-10-24 |
PE20010484A1 (es) | 2001-04-20 |
DE60005524T2 (de) | 2004-08-05 |
US20020197320A1 (en) | 2002-12-26 |
AU6219800A (en) | 2001-03-05 |
WO2001010407A1 (en) | 2001-02-15 |
PT1200065E (pt) | 2004-02-27 |
CN1160056C (zh) | 2004-08-04 |
HK1047538A1 (en) | 2003-02-28 |
SI1200065T1 (en) | 2004-04-30 |
HN2000000166A (es) | 2001-04-20 |
DE60005524D1 (de) | 2003-10-30 |
CN1360495A (zh) | 2002-07-24 |
TWI232111B (en) | 2005-05-11 |
NZ517039A (en) | 2003-01-31 |
ATE250408T1 (de) | 2003-10-15 |
MXPA02001320A (es) | 2004-09-10 |
DK1200065T3 (da) | 2004-02-02 |
MA26749A1 (fr) | 2004-12-20 |
ES2207532T3 (es) | 2004-06-01 |
PA8499101A1 (es) | 2001-12-14 |
EP1200065A1 (en) | 2002-05-02 |
CA2378572A1 (en) | 2001-02-15 |
AR025045A1 (es) | 2002-11-06 |
KR100670085B1 (ko) | 2007-01-17 |
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