KR20020019895A - [Ｓ-(Ｒ*,Ｓ*)-β-[[[1-[1-옥소-3-(4-피페리디닐)프로필]-3-피페리디닐]카보닐]아미노]-3-피리딘 프로판산 및유도체의 제조방법 - Google Patents

[Ｓ-(Ｒ*,Ｓ*)-β-[[[1-[1-옥소-3-(4-피페리디닐)프로필]-3-피페리디닐]카보닐]아미노]-3-피리딘 프로판산 및유도체의 제조방법 Download PDF

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Publication number
KR20020019895A
KR20020019895A KR1020017012100A KR20017012100A KR20020019895A KR 20020019895 A KR20020019895 A KR 20020019895A KR 1020017012100 A KR1020017012100 A KR 1020017012100A KR 20017012100 A KR20017012100 A KR 20017012100A KR 20020019895 A KR20020019895 A KR 20020019895A
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KR
South Korea
Prior art keywords
formula
compound
salt
reacting
hydrogen
Prior art date
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KR1020017012100A
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English (en)
Korean (ko)
Inventor
코헨주디스에이치.
주스투스미카엘
마리야노프신티아
로젤러아르민
슈로더프리트조프하르멘
소기커크엘.
빌라니프랭크존주니어
웨크리스티안
Original Assignee
오르토-맥네일 파마슈티칼, 인코퍼레이티드
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Application filed by 오르토-맥네일 파마슈티칼, 인코퍼레이티드 filed Critical 오르토-맥네일 파마슈티칼, 인코퍼레이티드
Publication of KR20020019895A publication Critical patent/KR20020019895A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020017012100A 1999-03-22 2000-03-21 [Ｓ-(Ｒ*,Ｓ*)-β-[[[1-[1-옥소-3-(4-피페리디닐)프로필]-3-피페리디닐]카보닐]아미노]-3-피리딘 프로판산 및유도체의 제조방법 Withdrawn KR20020019895A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12567199P 1999-03-22 1999-03-22
US60/125,671 1999-03-22
PCT/US2000/007462 WO2000056730A1 (en) 1999-03-22 2000-03-21 PROCESS FOR PREPARING [S-(R*,S*)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES

Publications (1)

Publication Number Publication Date
KR20020019895A true KR20020019895A (ko) 2002-03-13

Family

ID=22420863

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017012100A Withdrawn KR20020019895A (ko) 1999-03-22 2000-03-21 [Ｓ-(Ｒ*,Ｓ*)-β-[[[1-[1-옥소-3-(4-피페리디닐)프로필]-3-피페리디닐]카보닐]아미노]-3-피리딘 프로판산 및유도체의 제조방법

Country Status (22)

Country Link
US (2) US6515130B1 (enExample)
EP (1) EP1165543B1 (enExample)
JP (1) JP2002540108A (enExample)
KR (1) KR20020019895A (enExample)
CN (1) CN1351600A (enExample)
AT (1) ATE242235T1 (enExample)
AU (1) AU775413B2 (enExample)
BR (1) BR0010652A (enExample)
CA (1) CA2368024A1 (enExample)
CZ (1) CZ20013431A3 (enExample)
DE (1) DE60003169T2 (enExample)
DK (1) DK1165543T3 (enExample)
ES (1) ES2199805T3 (enExample)
HK (1) HK1046272A1 (enExample)
HR (1) HRP20010767A2 (enExample)
HU (1) HUP0201262A3 (enExample)
MX (1) MXPA01009615A (enExample)
PT (1) PT1165543E (enExample)
SK (1) SK13562001A3 (enExample)
UA (1) UA67832C2 (enExample)
WO (1) WO2000056730A1 (enExample)
YU (1) YU74601A (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1364159A (zh) 1999-03-22 2002-08-14 奥索-麦克尼尔药品公司 丙酸3－氨基－3－芳基酯的合成
CA2457965C (en) * 2001-09-21 2010-06-01 Sanofi-Synthelabo Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives
AU2012297137B2 (en) 2011-08-17 2017-03-02 Life Molecular Imaging Limited Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
US20160008490A1 (en) 2013-02-12 2016-01-14 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
EP4289819A3 (en) 2013-02-20 2024-01-10 Reuter Chemische Apparatebau e.K. Process for the preparation of enantiomerically enriched 3-aminopiperidine
WO2014173855A1 (en) 2013-04-22 2014-10-30 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
KR102548998B1 (ko) 2020-03-31 2023-06-29 재단법인 아산사회복지재단 혈전영상을 위한 방사성의약품 및 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58243B1 (en) 1983-12-07 1993-08-11 Lonza Ag A process for the preparation of optically-active 3-amino carboxylic acids
US5254573A (en) 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
ES2164109T3 (es) 1993-09-22 2002-02-16 Fujisawa Pharmaceutical Co Derivados de n-(3-piperidinilcarbonil)-beta-alanina como antagonistas de paf.
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
EP0888302A1 (en) * 1996-03-13 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. N- (r)-1- 3-(4-piperidyl)propionyl-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist
RU2194038C2 (ru) * 1996-05-01 2002-12-10 Орто-Макнейл Фармасьютикал, Инк. Карбоксамидные производные пирролидина или пиперидина, фармацевтическая композиция на их основе и способ ингибирования агрегации тромбоцитов
PT912495E (pt) 1996-07-12 2002-04-29 Searle & Co Sintese assimetrica de beta-aminoacidos quirais
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders

Also Published As

Publication number Publication date
AU3766100A (en) 2000-10-09
HK1046272A1 (zh) 2003-01-03
ATE242235T1 (de) 2003-06-15
DE60003169D1 (de) 2003-07-10
AU775413B2 (en) 2004-07-29
HRP20010767A2 (en) 2002-12-31
WO2000056730A1 (en) 2000-09-28
HU0201262D0 (enExample) 2002-05-29
EP1165543B1 (en) 2003-06-04
ES2199805T3 (es) 2004-03-01
DE60003169T2 (de) 2005-10-27
YU74601A (sh) 2004-05-12
PT1165543E (pt) 2003-10-31
MXPA01009615A (es) 2003-07-21
CZ20013431A3 (cs) 2003-04-16
HUP0201262A3 (en) 2003-12-29
DK1165543T3 (da) 2003-09-29
EP1165543A1 (en) 2002-01-02
US6515130B1 (en) 2003-02-04
BR0010652A (pt) 2002-07-16
US20020137937A1 (en) 2002-09-26
CN1351600A (zh) 2002-05-29
CA2368024A1 (en) 2000-09-28
UA67832C2 (uk) 2004-07-15
SK13562001A3 (sk) 2002-08-06
JP2002540108A (ja) 2002-11-26
HUP0201262A2 (en) 2002-08-28

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20010922

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid