BR0010652A - Processo de preparação de ácido [s-(r*,s*)]-beta-[[[1-[1-oxo-3-(4-piperidinil)propil]-3-piperi dinil]carbonil]amino]-3-piridinapropanóico e derivados - Google Patents
Processo de preparação de ácido [s-(r*,s*)]-beta-[[[1-[1-oxo-3-(4-piperidinil)propil]-3-piperi dinil]carbonil]amino]-3-piridinapropanóico e derivadosInfo
- Publication number
- BR0010652A BR0010652A BR0010652-6A BR0010652A BR0010652A BR 0010652 A BR0010652 A BR 0010652A BR 0010652 A BR0010652 A BR 0010652A BR 0010652 A BR0010652 A BR 0010652A
- Authority
- BR
- Brazil
- Prior art keywords
- oxo
- beta
- derivatives
- amino
- pyridinepropanoic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12567199P | 1999-03-22 | 1999-03-22 | |
| PCT/US2000/007462 WO2000056730A1 (en) | 1999-03-22 | 2000-03-21 | PROCESS FOR PREPARING [S-(R*,S*)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010652A true BR0010652A (pt) | 2002-07-16 |
Family
ID=22420863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010652-6A BR0010652A (pt) | 1999-03-22 | 2000-03-21 | Processo de preparação de ácido [s-(r*,s*)]-beta-[[[1-[1-oxo-3-(4-piperidinil)propil]-3-piperi dinil]carbonil]amino]-3-piridinapropanóico e derivados |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6515130B1 (enExample) |
| EP (1) | EP1165543B1 (enExample) |
| JP (1) | JP2002540108A (enExample) |
| KR (1) | KR20020019895A (enExample) |
| CN (1) | CN1351600A (enExample) |
| AT (1) | ATE242235T1 (enExample) |
| AU (1) | AU775413B2 (enExample) |
| BR (1) | BR0010652A (enExample) |
| CA (1) | CA2368024A1 (enExample) |
| CZ (1) | CZ20013431A3 (enExample) |
| DE (1) | DE60003169T2 (enExample) |
| DK (1) | DK1165543T3 (enExample) |
| ES (1) | ES2199805T3 (enExample) |
| HK (1) | HK1046272A1 (enExample) |
| HR (1) | HRP20010767A2 (enExample) |
| HU (1) | HUP0201262A3 (enExample) |
| MX (1) | MXPA01009615A (enExample) |
| PT (1) | PT1165543E (enExample) |
| SK (1) | SK13562001A3 (enExample) |
| UA (1) | UA67832C2 (enExample) |
| WO (1) | WO2000056730A1 (enExample) |
| YU (1) | YU74601A (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2367971A1 (en) | 1999-03-22 | 2000-09-28 | Ortho-Mcneil Pharmaceutical, Inc. | Synthesis of 3-amino-3-aryl propanoates |
| NZ547205A (en) * | 2001-09-21 | 2007-11-30 | Sanofi Aventis | Intermediates of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives |
| US9345793B2 (en) | 2011-08-17 | 2016-05-24 | Piramal Imaging Sa | Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi |
| CA2900595A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| KR102236806B1 (ko) | 2013-02-20 | 2021-04-06 | 로이터 케미쉐 아파라테바우 이.카. | 거울상 이성질체 농후화된 3-아미노피페리딘의 제조 방법 |
| EP2989080A1 (en) | 2013-04-22 | 2016-03-02 | Reuter Chemische Apparatebau KG | Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine |
| KR102548998B1 (ko) | 2020-03-31 | 2023-06-29 | 재단법인 아산사회복지재단 | 혈전영상을 위한 방사성의약품 및 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58243B1 (en) | 1983-12-07 | 1993-08-11 | Lonza Ag | A process for the preparation of optically-active 3-amino carboxylic acids |
| US5254573A (en) | 1991-10-15 | 1993-10-19 | Monsanto Company | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
| RU2161155C2 (ru) * | 1993-09-22 | 2000-12-27 | Фудзисава Фармасьютикал Ко., Лтд | Производные n-(3-пиперидинилкарбонил)-бета-аланина в качестве антагонистов фактора активации тромбоцитов (фат), способ получения, фармацевтическая композиция и способ лечения |
| US5770575A (en) * | 1994-03-16 | 1998-06-23 | Ortho Pharmaceutical Corporation | Nipecotic acid derivatives as antithrombotic compounds |
| KR19990087694A (ko) * | 1996-03-13 | 1999-12-27 | 후지야마 아키라 | 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌 |
| PT923555E (pt) * | 1996-05-01 | 2005-09-30 | Ortho Mcneil Pharm Inc | Derivados carboxamida de pirrolidina, piperidina e hexa-hidroazepina para o tratamento de disturbios tromboticos |
| JP2000514809A (ja) | 1996-07-12 | 2000-11-07 | ジー．ディー．サール アンド カンパニー | キラルβ―アミノ酸の不斉合成 |
| US6066651A (en) * | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
-
2000
- 2000-03-21 MX MXPA01009615A patent/MXPA01009615A/es unknown
- 2000-03-21 HK HK02107463.1A patent/HK1046272A1/zh unknown
- 2000-03-21 WO PCT/US2000/007462 patent/WO2000056730A1/en not_active Ceased
- 2000-03-21 ES ES00916573T patent/ES2199805T3/es not_active Expired - Lifetime
- 2000-03-21 DK DK00916573T patent/DK1165543T3/da active
- 2000-03-21 US US09/532,375 patent/US6515130B1/en not_active Expired - Lifetime
- 2000-03-21 KR KR1020017012100A patent/KR20020019895A/ko not_active Withdrawn
- 2000-03-21 EP EP00916573A patent/EP1165543B1/en not_active Expired - Lifetime
- 2000-03-21 BR BR0010652-6A patent/BR0010652A/pt not_active IP Right Cessation
- 2000-03-21 HU HU0201262A patent/HUP0201262A3/hu unknown
- 2000-03-21 AU AU37661/00A patent/AU775413B2/en not_active Ceased
- 2000-03-21 CA CA002368024A patent/CA2368024A1/en not_active Abandoned
- 2000-03-21 HR HR20010767A patent/HRP20010767A2/hr not_active Application Discontinuation
- 2000-03-21 UA UA2001096538A patent/UA67832C2/uk unknown
- 2000-03-21 AT AT00916573T patent/ATE242235T1/de not_active IP Right Cessation
- 2000-03-21 CZ CZ20013431A patent/CZ20013431A3/cs unknown
- 2000-03-21 YU YU74601A patent/YU74601A/sh unknown
- 2000-03-21 JP JP2000606591A patent/JP2002540108A/ja active Pending
- 2000-03-21 CN CN00807617A patent/CN1351600A/zh active Pending
- 2000-03-21 SK SK1356-2001A patent/SK13562001A3/sk unknown
- 2000-03-21 PT PT00916573T patent/PT1165543E/pt unknown
- 2000-03-21 DE DE60003169T patent/DE60003169T2/de not_active Expired - Fee Related
-
2002
- 2002-02-22 US US10/081,289 patent/US20020137937A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60003169T2 (de) | 2005-10-27 |
| HK1046272A1 (zh) | 2003-01-03 |
| AU775413B2 (en) | 2004-07-29 |
| WO2000056730A1 (en) | 2000-09-28 |
| HUP0201262A2 (en) | 2002-08-28 |
| CN1351600A (zh) | 2002-05-29 |
| MXPA01009615A (es) | 2003-07-21 |
| CZ20013431A3 (cs) | 2003-04-16 |
| CA2368024A1 (en) | 2000-09-28 |
| US6515130B1 (en) | 2003-02-04 |
| US20020137937A1 (en) | 2002-09-26 |
| KR20020019895A (ko) | 2002-03-13 |
| ATE242235T1 (de) | 2003-06-15 |
| UA67832C2 (uk) | 2004-07-15 |
| AU3766100A (en) | 2000-10-09 |
| SK13562001A3 (sk) | 2002-08-06 |
| EP1165543B1 (en) | 2003-06-04 |
| EP1165543A1 (en) | 2002-01-02 |
| ES2199805T3 (es) | 2004-03-01 |
| YU74601A (sh) | 2004-05-12 |
| HUP0201262A3 (en) | 2003-12-29 |
| JP2002540108A (ja) | 2002-11-26 |
| DE60003169D1 (de) | 2003-07-10 |
| HU0201262D0 (enExample) | 2002-05-29 |
| DK1165543T3 (da) | 2003-09-29 |
| PT1165543E (pt) | 2003-10-31 |
| HRP20010767A2 (en) | 2002-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009. |