HUP0201262A3 - Process for preparing [s-(r*,s*)]-betha-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives - Google Patents

Process for preparing [s-(r*,s*)]-betha-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives

Info

Publication number
HUP0201262A3
HUP0201262A3 HU0201262A HUP0201262A HUP0201262A3 HU P0201262 A3 HUP0201262 A3 HU P0201262A3 HU 0201262 A HU0201262 A HU 0201262A HU P0201262 A HUP0201262 A HU P0201262A HU P0201262 A3 HUP0201262 A3 HU P0201262A3
Authority
HU
Hungary
Prior art keywords
piperidinyl
betha
oxo
carbonyl
propyl
Prior art date
Application number
HU0201262A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of HU0201262D0 publication Critical patent/HU0201262D0/hu
Publication of HUP0201262A2 publication Critical patent/HUP0201262A2/hu
Publication of HUP0201262A3 publication Critical patent/HUP0201262A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0201262A 1999-03-22 2000-03-21 Process for preparing [s-(r*,s*)]-betha-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives HUP0201262A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12567199P 1999-03-22 1999-03-22

Publications (3)

Publication Number Publication Date
HU0201262D0 HU0201262D0 (enExample) 2002-05-29
HUP0201262A2 HUP0201262A2 (en) 2002-08-28
HUP0201262A3 true HUP0201262A3 (en) 2003-12-29

Family

ID=22420863

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201262A HUP0201262A3 (en) 1999-03-22 2000-03-21 Process for preparing [s-(r*,s*)]-betha-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives

Country Status (22)

Country Link
US (2) US6515130B1 (enExample)
EP (1) EP1165543B1 (enExample)
JP (1) JP2002540108A (enExample)
KR (1) KR20020019895A (enExample)
CN (1) CN1351600A (enExample)
AT (1) ATE242235T1 (enExample)
AU (1) AU775413B2 (enExample)
BR (1) BR0010652A (enExample)
CA (1) CA2368024A1 (enExample)
CZ (1) CZ20013431A3 (enExample)
DE (1) DE60003169T2 (enExample)
DK (1) DK1165543T3 (enExample)
ES (1) ES2199805T3 (enExample)
HK (1) HK1046272A1 (enExample)
HR (1) HRP20010767A2 (enExample)
HU (1) HUP0201262A3 (enExample)
MX (1) MXPA01009615A (enExample)
PT (1) PT1165543E (enExample)
SK (1) SK13562001A3 (enExample)
UA (1) UA67832C2 (enExample)
WO (1) WO2000056730A1 (enExample)
YU (1) YU74601A (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201263A3 (en) 1999-03-22 2003-05-28 Ortho Mcneil Pharm Inc Synthesis of 3-amino-3-aryl propanoates and intermediates
NZ531243A (en) * 2001-09-21 2006-08-31 Sanofi Aventis Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-A]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-A]pyrimidin-5(1H)one derivatives
EP2744802B1 (en) 2011-08-17 2017-01-04 Piramal Imaging SA Compounds for binding to the platelet specific glycoprotein iib/iiia and their use for imaging of thrombi
WO2014124943A1 (en) 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
EP4289819A3 (en) 2013-02-20 2024-01-10 Reuter Chemische Apparatebau e.K. Process for the preparation of enantiomerically enriched 3-aminopiperidine
WO2014173855A1 (en) 2013-04-22 2014-10-30 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
KR102548998B1 (ko) 2020-03-31 2023-06-29 재단법인 아산사회복지재단 혈전영상을 위한 방사성의약품 및 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58243B1 (en) 1983-12-07 1993-08-11 Lonza Ag A process for the preparation of optically-active 3-amino carboxylic acids
US5254573A (en) 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
CN1041919C (zh) * 1993-09-22 1999-02-03 藤泽药品工业株式会社 用作血小板激活因子拮抗物的N-(3-哌啶基碳酰)-β-氨基丙酸衍生物
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
CA2248809A1 (en) * 1996-03-13 1997-09-18 Fujisawa Pharmaceutical Co., Ltd. N-[(r)-1-{3-(4-piperidyl)propionyl}-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist
DE69739239D1 (de) * 1996-05-01 2009-03-19 Ortho Mcneil Pharm Inc Carboxamidderivate von Pyrrolidin, Piperidin und Hexahydropiperizin für Behandlung von Thrombosen
ES2167758T3 (es) 1996-07-12 2002-05-16 Searle & Co Sintesis asimetrica de beta-aminoacidos quirales.
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders

Also Published As

Publication number Publication date
BR0010652A (pt) 2002-07-16
HRP20010767A2 (en) 2002-12-31
SK13562001A3 (sk) 2002-08-06
DE60003169T2 (de) 2005-10-27
CN1351600A (zh) 2002-05-29
KR20020019895A (ko) 2002-03-13
DK1165543T3 (da) 2003-09-29
CA2368024A1 (en) 2000-09-28
JP2002540108A (ja) 2002-11-26
ATE242235T1 (de) 2003-06-15
AU775413B2 (en) 2004-07-29
DE60003169D1 (de) 2003-07-10
US20020137937A1 (en) 2002-09-26
EP1165543A1 (en) 2002-01-02
UA67832C2 (uk) 2004-07-15
WO2000056730A1 (en) 2000-09-28
MXPA01009615A (es) 2003-07-21
PT1165543E (pt) 2003-10-31
EP1165543B1 (en) 2003-06-04
YU74601A (sh) 2004-05-12
US6515130B1 (en) 2003-02-04
HU0201262D0 (enExample) 2002-05-29
HK1046272A1 (zh) 2003-01-03
ES2199805T3 (es) 2004-03-01
AU3766100A (en) 2000-10-09
HUP0201262A2 (en) 2002-08-28
CZ20013431A3 (cs) 2003-04-16

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