KR20010022828A - 유착 억제제로서의 시클로펩티드 유도체 - Google Patents

유착 억제제로서의 시클로펩티드 유도체 Download PDF

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Publication number
KR20010022828A
KR20010022828A KR1020007001430A KR20007001430A KR20010022828A KR 20010022828 A KR20010022828 A KR 20010022828A KR 1020007001430 A KR1020007001430 A KR 1020007001430A KR 20007001430 A KR20007001430 A KR 20007001430A KR 20010022828 A KR20010022828 A KR 20010022828A
Authority
KR
South Korea
Prior art keywords
formula
compound
acid
salts
independently
Prior art date
Application number
KR1020007001430A
Other languages
English (en)
Korean (ko)
Inventor
홀쩨만귄터
굿맨시몬
Original Assignee
플레믹 크리스티안
메르크 파텐트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 플레믹 크리스티안, 메르크 파텐트 게엠베하 filed Critical 플레믹 크리스티안
Publication of KR20010022828A publication Critical patent/KR20010022828A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020007001430A 1997-08-23 1998-08-14 유착 억제제로서의 시클로펩티드 유도체 KR20010022828A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19736772A DE19736772A1 (de) 1997-08-23 1997-08-23 Cyclopeptidderivate
DE19736772.0 1997-08-23
PCT/EP1998/005161 WO1999010371A2 (fr) 1997-08-23 1998-08-14 Derives de cyclopeptide utilises comme inhibiteurs d'adherence

Publications (1)

Publication Number Publication Date
KR20010022828A true KR20010022828A (ko) 2001-03-26

Family

ID=7839977

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007001430A KR20010022828A (ko) 1997-08-23 1998-08-14 유착 억제제로서의 시클로펩티드 유도체

Country Status (18)

Country Link
EP (1) EP1007545A2 (fr)
JP (1) JP2001514186A (fr)
KR (1) KR20010022828A (fr)
CN (1) CN1267306A (fr)
AR (1) AR013650A1 (fr)
AU (1) AU734829B2 (fr)
BR (1) BR9811992A (fr)
CA (1) CA2301182A1 (fr)
DE (1) DE19736772A1 (fr)
HU (1) HUP0003500A3 (fr)
ID (1) ID23952A (fr)
NO (1) NO20000860L (fr)
PL (1) PL341090A1 (fr)
RU (1) RU2200166C2 (fr)
SK (1) SK2132000A3 (fr)
TW (1) TW477793B (fr)
WO (1) WO1999010371A2 (fr)
ZA (1) ZA987558B (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE4415310A1 (de) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
JPH07316193A (ja) * 1994-05-24 1995-12-05 Asahi Glass Co Ltd ペプチド誘導体およびその用途

Also Published As

Publication number Publication date
EP1007545A2 (fr) 2000-06-14
WO1999010371A3 (fr) 1999-05-27
JP2001514186A (ja) 2001-09-11
NO20000860D0 (no) 2000-02-22
WO1999010371A2 (fr) 1999-03-04
BR9811992A (pt) 2000-09-05
AU734829B2 (en) 2001-06-21
DE19736772A1 (de) 1999-02-25
SK2132000A3 (en) 2000-09-12
AU9531998A (en) 1999-03-16
PL341090A1 (en) 2001-03-26
RU2200166C2 (ru) 2003-03-10
TW477793B (en) 2002-03-01
ZA987558B (en) 1999-02-23
HUP0003500A3 (en) 2001-12-28
CN1267306A (zh) 2000-09-20
AR013650A1 (es) 2001-01-10
HUP0003500A2 (hu) 2001-02-28
CA2301182A1 (fr) 1999-03-04
NO20000860L (no) 2000-02-22
ID23952A (id) 2000-06-08

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