KR20000071160A - 4-아미노알콕시-1,3-디하이드로벤조이미다졸-2-온 유도체, 이의 제조방법 및 도파민 자가수용체(ｄ2) 효능제로서의 용도 - Google Patents
4-아미노알콕시-1,3-디하이드로벤조이미다졸-2-온 유도체, 이의 제조방법 및 도파민 자가수용체(ｄ2) 효능제로서의 용도 Download PDFInfo
- Publication number
- KR20000071160A KR20000071160A KR1019997007450A KR19997007450A KR20000071160A KR 20000071160 A KR20000071160 A KR 20000071160A KR 1019997007450 A KR1019997007450 A KR 1019997007450A KR 19997007450 A KR19997007450 A KR 19997007450A KR 20000071160 A KR20000071160 A KR 20000071160A
- Authority
- KR
- South Korea
- Prior art keywords
- dihydro
- ethoxy
- alkyl
- benzoimidazol
- compound
- Prior art date
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract description 36
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- 150000003839 salts Chemical class 0.000 claims abstract description 20
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 10
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract description 5
- 206010013663 drug dependence Diseases 0.000 claims abstract description 5
- 125000002541 furyl group Chemical group 0.000 claims abstract description 5
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 5
- 208000011117 substance-related disease Diseases 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 5
- 125000001544 thienyl group Chemical group 0.000 claims abstract description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- MUGIIZXLOBYZRQ-UHFFFAOYSA-N 4-[2-(benzylamino)ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C=12NC(=O)NC2=CC=CC=1OCCNCC1=CC=CC=C1 MUGIIZXLOBYZRQ-UHFFFAOYSA-N 0.000 claims description 3
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- MBJXHVIXQALVPG-UHFFFAOYSA-N 4-[2-(3,4-dihydro-1h-isoquinolin-2-yl)ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C1CC2=CC=CC=C2CN1CCOC1=C(NC(=O)N2)C2=CC=C1 MBJXHVIXQALVPG-UHFFFAOYSA-N 0.000 claims description 2
- YKNNRQLCQGQFRB-UHFFFAOYSA-N 4-[2-(benzylamino)ethoxy]-6-chloro-1,3-dihydrobenzimidazol-2-one Chemical compound C=12NC(=O)NC2=CC(Cl)=CC=1OCCNCC1=CC=CC=C1 YKNNRQLCQGQFRB-UHFFFAOYSA-N 0.000 claims description 2
- IGXRMBYELXTTHC-UHFFFAOYSA-N 4-[2-(naphthalen-1-ylmethylamino)ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C1=CC=C2C(CNCCOC=3C=CC=C4NC(NC4=3)=O)=CC=CC2=C1 IGXRMBYELXTTHC-UHFFFAOYSA-N 0.000 claims description 2
- LABNUEBHKOIKCA-UHFFFAOYSA-N 4-[2-(thiophen-2-ylmethylamino)ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C=12NC(=O)NC2=CC=CC=1OCCNCC1=CC=CS1 LABNUEBHKOIKCA-UHFFFAOYSA-N 0.000 claims description 2
- REGHGAYSMQIHPM-UHFFFAOYSA-N 4-[2-[(4-chlorophenyl)methylamino]ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C1=CC(Cl)=CC=C1CNCCOC1=CC=CC2=C1NC(=O)N2 REGHGAYSMQIHPM-UHFFFAOYSA-N 0.000 claims description 2
- ZNLZWRCKANRAHW-UHFFFAOYSA-N 4-[2-[(4-methylphenyl)methylamino]ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C1=CC(C)=CC=C1CNCCOC1=CC=CC2=C1NC(=O)N2 ZNLZWRCKANRAHW-UHFFFAOYSA-N 0.000 claims description 2
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- WGVXBIYOGAUGSS-UHFFFAOYSA-N 4-[3-(benzylamino)propoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C=12NC(=O)NC2=CC=CC=1OCCCNCC1=CC=CC=C1 WGVXBIYOGAUGSS-UHFFFAOYSA-N 0.000 claims description 2
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- LZXRHUAIKBCBCN-UHFFFAOYSA-N 6-chloro-4-[2-(thiophen-3-ylmethylamino)ethoxy]-1,3-dihydrobenzimidazol-2-one Chemical compound C=12NC(=O)NC2=CC(Cl)=CC=1OCCNCC=1C=CSC=1 LZXRHUAIKBCBCN-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80187097A | 1997-02-18 | 1997-02-18 | |
| US8/801,870 | 1997-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20000071160A true KR20000071160A (ko) | 2000-11-25 |
Family
ID=25182225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997007450A KR20000071160A (ko) | 1997-02-18 | 1998-01-13 | 4-아미노알콕시-1,3-디하이드로벤조이미다졸-2-온 유도체, 이의 제조방법 및 도파민 자가수용체(ｄ2) 효능제로서의 용도 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0964853A1 (pt) |
| JP (1) | JP2001511804A (pt) |
| KR (1) | KR20000071160A (pt) |
| CN (1) | CN1138761C (pt) |
| AR (1) | AR011138A1 (pt) |
| AU (1) | AU744443B2 (pt) |
| BR (1) | BR9807703A (pt) |
| CA (1) | CA2278747A1 (pt) |
| HU (1) | HUP0001262A3 (pt) |
| IL (1) | IL131156A0 (pt) |
| NZ (1) | NZ337271A (pt) |
| TW (1) | TW383303B (pt) |
| WO (1) | WO1998035946A1 (pt) |
| ZA (1) | ZA981310B (pt) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
| GB9210632D0 (en) * | 1992-05-19 | 1992-07-01 | Fisons Plc | Compounds |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| AR004523A1 (es) * | 1995-11-06 | 1998-12-16 | American Home Prod | 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| AU4091797A (en) * | 1996-08-27 | 1998-03-19 | American Home Products Corporation | 4-aminoethoxy-indolone derivatives as dopamine d2 agonists |
| EP0923551B1 (en) * | 1996-08-27 | 2002-06-05 | American Home Products Corporation | 4-aminoethoxy indolone derivatives |
-
1998
- 1998-01-13 HU HU0001262A patent/HUP0001262A3/hu unknown
- 1998-01-13 EP EP98903469A patent/EP0964853A1/en not_active Withdrawn
- 1998-01-13 AU AU60234/98A patent/AU744443B2/en not_active Ceased
- 1998-01-13 IL IL13115698A patent/IL131156A0/xx unknown
- 1998-01-13 NZ NZ337271A patent/NZ337271A/xx unknown
- 1998-01-13 WO PCT/US1998/000623 patent/WO1998035946A1/en not_active Application Discontinuation
- 1998-01-13 BR BR9807703-1A patent/BR9807703A/pt not_active IP Right Cessation
- 1998-01-13 CN CNB988041197A patent/CN1138761C/zh not_active Expired - Fee Related
- 1998-01-13 KR KR1019997007450A patent/KR20000071160A/ko not_active Application Discontinuation
- 1998-01-13 JP JP53572998A patent/JP2001511804A/ja active Pending
- 1998-01-13 CA CA002278747A patent/CA2278747A1/en not_active Abandoned
- 1998-02-05 TW TW087101495A patent/TW383303B/zh not_active IP Right Cessation
- 1998-02-11 AR ARP980100620A patent/AR011138A1/es not_active Application Discontinuation
- 1998-02-17 ZA ZA9801310A patent/ZA981310B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA981310B (en) | 1999-08-17 |
| JP2001511804A (ja) | 2001-08-14 |
| NZ337271A (en) | 2001-01-26 |
| CN1252060A (zh) | 2000-05-03 |
| TW383303B (en) | 2000-03-01 |
| AR011138A1 (es) | 2000-08-02 |
| HUP0001262A3 (en) | 2002-04-29 |
| CA2278747A1 (en) | 1998-08-20 |
| EP0964853A1 (en) | 1999-12-22 |
| BR9807703A (pt) | 2000-05-02 |
| WO1998035946A1 (en) | 1998-08-20 |
| AU6023498A (en) | 1998-09-08 |
| AU744443B2 (en) | 2002-02-21 |
| HUP0001262A2 (hu) | 2001-04-28 |
| IL131156A0 (en) | 2001-01-28 |
| CN1138761C (zh) | 2004-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |