BR9807703A - Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina - Google Patents

Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina

Info

Publication number
BR9807703A
BR9807703A BR9807703-1A BR9807703A BR9807703A BR 9807703 A BR9807703 A BR 9807703A BR 9807703 A BR9807703 A BR 9807703A BR 9807703 A BR9807703 A BR 9807703A
Authority
BR
Brazil
Prior art keywords
preparations
hydrogen
receptor agonists
derivatives
dopamine
Prior art date
Application number
BR9807703-1A
Other languages
English (en)
Inventor
Richard Eric Mewshaw
James Albert Nelson
Uresh Shantilal Shah
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9807703A publication Critical patent/BR9807703A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE 4-AMINOALCóXI-1,3-DIIDROBENZOIMIDAZOL-2-ONA, SUAS PREPARAçõES E SEUS USOS COMO AGONISTAS (D2) AUTO-RECEPTORES DA DOPAMINA"<D>. São revelados compostos de fórmula (I), em que R^ 1^ é hidrogênio ou C1-C~ 6~ alquila; R^ 2^ é selecionado a partir de hidrogênio, C1-C~ 10~alquila de cadeia linear e ramificada, cicloexilmetila ou -(CH~ 2~)~ m~Ar, onde Ar é fenila, naftila, tienila, furanila ou piridinila, cada um opcionalmente substituído por um ou dois substituintes selecionados independentemente a partir de C1-C6 alquila, halogênio, C1-C6 alcóxi; e trifluorometila; ou N R^ 1^ R^ 2^ é 1,2,3,4-tetraidroquinolin-1-ila ou 1,2,3,4-tetraidroisoquinolin-2-ila m é 1-5; n é 1 ou 2; R^ 3^ é hidrogênio ou C1-C6alquila; Y é halogênio, C1-C6alquila e C1-C6alcóxi; ou um seu sal farmaceuticamente aceitável, que são agonistas auto-receptores da dopamina e como tal são úteis no tratamento da esquizofrenia, doença de PARKINSON, SìNDROME DE Tourette e vício a álcool e a drogas.
BR9807703-1A 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina BR9807703A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80187097A 1997-02-18 1997-02-18
PCT/US1998/000623 WO1998035946A1 (en) 1997-02-18 1998-01-13 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists

Publications (1)

Publication Number Publication Date
BR9807703A true BR9807703A (pt) 2000-05-02

Family

ID=25182225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807703-1A BR9807703A (pt) 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina

Country Status (14)

Country Link
EP (1) EP0964853A1 (pt)
JP (1) JP2001511804A (pt)
KR (1) KR20000071160A (pt)
CN (1) CN1138761C (pt)
AR (1) AR011138A1 (pt)
AU (1) AU744443B2 (pt)
BR (1) BR9807703A (pt)
CA (1) CA2278747A1 (pt)
HU (1) HUP0001262A3 (pt)
IL (1) IL131156A0 (pt)
NZ (1) NZ337271A (pt)
TW (1) TW383303B (pt)
WO (1) WO1998035946A1 (pt)
ZA (1) ZA981310B (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
AR004523A1 (es) * 1995-11-06 1998-12-16 American Home Prod 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
JP2000516959A (ja) * 1996-08-27 2000-12-19 アメリカン・ホーム・プロダクツ・コーポレイション ４―アミノエトキシインドロン誘導体
CA2264072A1 (en) * 1996-08-27 1998-03-05 American Home Products Corporation 4-aminoethoxy-indolone derivatives as dopamine d2 agonists

Also Published As

Publication number Publication date
AU6023498A (en) 1998-09-08
KR20000071160A (ko) 2000-11-25
WO1998035946A1 (en) 1998-08-20
EP0964853A1 (en) 1999-12-22
NZ337271A (en) 2001-01-26
HUP0001262A3 (en) 2002-04-29
TW383303B (en) 2000-03-01
CA2278747A1 (en) 1998-08-20
AR011138A1 (es) 2000-08-02
JP2001511804A (ja) 2001-08-14
HUP0001262A2 (hu) 2001-04-28
CN1252060A (zh) 2000-05-03
ZA981310B (en) 1999-08-17
IL131156A0 (en) 2001-01-28
AU744443B2 (en) 2002-02-21
CN1138761C (zh) 2004-02-18

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007.