BR9807703A - Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina - Google Patents

Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina

Info

Publication number
BR9807703A
BR9807703A BR9807703-1A BR9807703A BR9807703A BR 9807703 A BR9807703 A BR 9807703A BR 9807703 A BR9807703 A BR 9807703A BR 9807703 A BR9807703 A BR 9807703A
Authority
BR
Brazil
Prior art keywords
preparations
hydrogen
receptor agonists
derivatives
dopamine
Prior art date
Application number
BR9807703-1A
Other languages
English (en)
Inventor
Richard Eric Mewshaw
James Albert Nelson
Uresh Shantilal Shah
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9807703A publication Critical patent/BR9807703A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE 4-AMINOALCóXI-1,3-DIIDROBENZOIMIDAZOL-2-ONA, SUAS PREPARAçõES E SEUS USOS COMO AGONISTAS (D2) AUTO-RECEPTORES DA DOPAMINA"<D>. São revelados compostos de fórmula (I), em que R^ 1^ é hidrogênio ou C1-C~ 6~ alquila; R^ 2^ é selecionado a partir de hidrogênio, C1-C~ 10~alquila de cadeia linear e ramificada, cicloexilmetila ou -(CH~ 2~)~ m~Ar, onde Ar é fenila, naftila, tienila, furanila ou piridinila, cada um opcionalmente substituído por um ou dois substituintes selecionados independentemente a partir de C1-C6 alquila, halogênio, C1-C6 alcóxi; e trifluorometila; ou N R^ 1^ R^ 2^ é 1,2,3,4-tetraidroquinolin-1-ila ou 1,2,3,4-tetraidroisoquinolin-2-ila m é 1-5; n é 1 ou 2; R^ 3^ é hidrogênio ou C1-C6alquila; Y é halogênio, C1-C6alquila e C1-C6alcóxi; ou um seu sal farmaceuticamente aceitável, que são agonistas auto-receptores da dopamina e como tal são úteis no tratamento da esquizofrenia, doença de PARKINSON, SìNDROME DE Tourette e vício a álcool e a drogas.
BR9807703-1A 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina BR9807703A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80187097A 1997-02-18 1997-02-18
PCT/US1998/000623 WO1998035946A1 (en) 1997-02-18 1998-01-13 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists

Publications (1)

Publication Number Publication Date
BR9807703A true BR9807703A (pt) 2000-05-02

Family

ID=25182225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807703-1A BR9807703A (pt) 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina

Country Status (14)

Country Link
EP (1) EP0964853A1 (pt)
JP (1) JP2001511804A (pt)
KR (1) KR20000071160A (pt)
CN (1) CN1138761C (pt)
AR (1) AR011138A1 (pt)
AU (1) AU744443B2 (pt)
BR (1) BR9807703A (pt)
CA (1) CA2278747A1 (pt)
HU (1) HUP0001262A3 (pt)
IL (1) IL131156A0 (pt)
NZ (1) NZ337271A (pt)
TW (1) TW383303B (pt)
WO (1) WO1998035946A1 (pt)
ZA (1) ZA981310B (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
AR004523A1 (es) * 1995-11-06 1998-12-16 American Home Prod 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
AU4091797A (en) * 1996-08-27 1998-03-19 American Home Products Corporation 4-aminoethoxy-indolone derivatives as dopamine d2 agonists
EP0923551B1 (en) * 1996-08-27 2002-06-05 American Home Products Corporation 4-aminoethoxy indolone derivatives

Also Published As

Publication number Publication date
ZA981310B (en) 1999-08-17
JP2001511804A (ja) 2001-08-14
NZ337271A (en) 2001-01-26
CN1252060A (zh) 2000-05-03
TW383303B (en) 2000-03-01
AR011138A1 (es) 2000-08-02
HUP0001262A3 (en) 2002-04-29
CA2278747A1 (en) 1998-08-20
EP0964853A1 (en) 1999-12-22
WO1998035946A1 (en) 1998-08-20
AU6023498A (en) 1998-09-08
AU744443B2 (en) 2002-02-21
HUP0001262A2 (hu) 2001-04-28
IL131156A0 (en) 2001-01-28
KR20000071160A (ko) 2000-11-25
CN1138761C (zh) 2004-02-18

Similar Documents

Publication Publication Date Title
DE60010076D1 (de) Chinolinderivate als antibakterielle mittel
NO20061657L (no) Pyrolderivater med antibakteriell aktivitet
EP1259487B8 (en) 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors
TW200502230A (en) Dual nk1/nk3 derivatives
MXPA05007352A (es) Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.
BRPI0515488A (pt) derivados de heterocìclicos e seu uso como agentes terapêuticos
NO20060981L (no) Pyridazinderivater og deres anvendelse som terapeutiske midler
EP1566379A4 (en) QUINOLINE AND QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FLT3 AND MEDICAL COMPOSITIONS CONTAINING SAME
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
UA94901C2 (ru) Антибактериальные производные пиперидина
GEP20156267B (en) 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES
DE60206911D1 (de) Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren
DE602005022764D1 (de) Piperidin- und azetidinderivate als glyt1-inhibitoren
TW200716650A (en) Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-met autophosphorylation inhibiting potency
BRPI0418074A (pt) derivado de amida e medicamento
NO324219B1 (no) Fenylpyridazin-forbindelser, medisiner og farmasoytiske preparater inneholdende disse samt anvendelse av disse for fremstilling av medikamenter for behandling av sykdom
MY140630A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
NO20072089L (no) Benzimidazolderivater, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav
SE0301701D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DK0992509T3 (da) Nye makrolid-derivater
NO20063619L (no) Diarylmetylpiperazinderivater, fremstilling og anvendelse derav
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DE69916066D1 (de) Neue benzoxazole mit pde-hemmender wirkung
NO20055997L (no) Diarylmetylidenpiperidinderivater og deres anvendelse som opiodreseptoragonister

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007.