KR102918597B1 - 항-인자 XI/XIa 항체를 사용한 치료 방법 - Google Patents

항-인자 XI/XIa 항체를 사용한 치료 방법

Info

Publication number
KR102918597B1
KR102918597B1 KR1020247029148A KR20247029148A KR102918597B1 KR 102918597 B1 KR102918597 B1 KR 102918597B1 KR 1020247029148 A KR1020247029148 A KR 1020247029148A KR 20247029148 A KR20247029148 A KR 20247029148A KR 102918597 B1 KR102918597 B1 KR 102918597B1
Authority
KR
South Korea
Prior art keywords
antibody
seq
chain variable
variable region
fxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020247029148A
Other languages
English (en)
Korean (ko)
Other versions
KR20240134248A (ko
Inventor
캐롤라 프리드먼
위아서 크더
마틴 레프코위즈
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Priority to KR1020267002235A priority Critical patent/KR20260023597A/ko
Publication of KR20240134248A publication Critical patent/KR20240134248A/ko
Application granted granted Critical
Publication of KR102918597B1 publication Critical patent/KR102918597B1/ko
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Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020247029148A 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법 Active KR102918597B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267002235A KR20260023597A (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662438654P 2016-12-23 2016-12-23
US62/438,654 2016-12-23
US201762589851P 2017-11-22 2017-11-22
US62/589,851 2017-11-22
KR1020197021024A KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
PCT/IB2017/058345 WO2018116267A2 (en) 2016-12-23 2017-12-22 Methods of treatment with anti-factor xi/xia antibodies

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197021024A Division KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267002235A Division KR20260023597A (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Publications (2)

Publication Number Publication Date
KR20240134248A KR20240134248A (ko) 2024-09-06
KR102918597B1 true KR102918597B1 (ko) 2026-01-28

Family

ID=61022382

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020247029148A Active KR102918597B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
KR1020197021024A Active KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
KR1020267002235A Pending KR20260023597A (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020197021024A Active KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
KR1020267002235A Pending KR20260023597A (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Country Status (9)

Country Link
US (3) US20200231701A1 (enExample)
EP (1) EP3558370A2 (enExample)
JP (2) JP7110199B2 (enExample)
KR (3) KR102918597B1 (enExample)
CN (2) CN118320078A (enExample)
AU (2) AU2017383537B2 (enExample)
CA (1) CA3048157A1 (enExample)
IL (2) IL267519B2 (enExample)
WO (1) WO2018116267A2 (enExample)

Families Citing this family (12)

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CA2963166C (en) 2014-10-01 2023-10-03 Medimmune Limited Antibodies to ticagrelor and methods of use
UY36751A (es) 2015-06-26 2017-01-31 Novartis Ag Anticuerpos de factor xi y métodos de uso
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
US20200231701A1 (en) * 2016-12-23 2020-07-23 Novartis Ag Methods of treatment with anti-factor xi/xia antibodies
BR112019012667A2 (pt) 2016-12-23 2020-02-11 Novartis Ag Anticorpos do fator xi e métodos de uso
FI3852617T3 (fi) * 2018-09-20 2025-10-21 Sfj Pharma X Inc Vasta-ainefragmenttien käyttö tikagrelorin aktiivisuuden kääntämiseen
WO2020211674A1 (zh) * 2019-04-16 2020-10-22 四川科伦博泰生物医药股份有限公司 抗FXI/FXIa抗体及其用途
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
CN115003325A (zh) * 2019-12-20 2022-09-02 安托斯治疗股份有限公司 因子xi/xia抗体的药物制剂和剂量方案
KR20230034361A (ko) * 2020-07-02 2023-03-09 베이징 투오 지에 바이오파마수티컬 컴퍼니 리미티드 항-fxi/fxia 항체, 이의 항원-결합 단편, 및 이의 약제학적 용도
TW202405022A (zh) * 2022-06-24 2024-02-01 美商安瑟斯治療公司 與抗因子ｘｉ／因子ｘｉａ抗體之組合療法
WO2025201156A1 (zh) * 2024-03-28 2025-10-02 施能康生物医药（苏州）有限公司 靶向凝血因子xi的核酸及其用途

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Also Published As

Publication number Publication date
IL267519B1 (en) 2024-12-01
JP2022141831A (ja) 2022-09-29
JP7500662B2 (ja) 2024-06-17
CN110325211A (zh) 2019-10-11
KR20260023597A (ko) 2026-02-20
KR102702288B1 (ko) 2024-09-05
CA3048157A1 (en) 2018-06-28
KR20240134248A (ko) 2024-09-06
JP2024116221A (ja) 2024-08-27
WO2018116267A3 (en) 2018-08-02
IL267519B2 (en) 2025-04-01
US20230002507A1 (en) 2023-01-05
US20250197522A1 (en) 2025-06-19
CN118320078A (zh) 2024-07-12
EP3558370A2 (en) 2019-10-30
AU2024287181A1 (en) 2025-03-06
IL316673A (en) 2024-12-01
IL267519A (en) 2019-08-29
JP7110199B2 (ja) 2022-08-01
KR20190099256A (ko) 2019-08-26
WO2018116267A2 (en) 2018-06-28
US20200231701A1 (en) 2020-07-23
AU2017383537B2 (en) 2024-10-03
AU2017383537A1 (en) 2019-06-27
JP2020504110A (ja) 2020-02-06

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