JP7110199B2 - 抗第ＸＩ／ＸＩａ因子抗体による処置法 - Google Patents

抗第ＸＩ／ＸＩａ因子抗体による処置法 Download PDF

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JP7110199B2
JP7110199B2 JP2019533396A JP2019533396A JP7110199B2 JP 7110199 B2 JP7110199 B2 JP 7110199B2 JP 2019533396 A JP2019533396 A JP 2019533396A JP 2019533396 A JP2019533396 A JP 2019533396A JP 7110199 B2 JP7110199 B2 JP 7110199B2
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antibody
fxi
seq
amino acid
fxia
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JP2020504110A5 (enExample
JP2020504110A (ja
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フリードマン，カローラ
キーダー，ヤセル
レフコウィッツ，マーティン
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019533396A 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法 Active JP7110199B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022115212A JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A JP7864156B2 (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438654P 2016-12-23 2016-12-23
US62/438,654 2016-12-23
US201762589851P 2017-11-22 2017-11-22
US62/589,851 2017-11-22
PCT/IB2017/058345 WO2018116267A2 (en) 2016-12-23 2017-12-22 Methods of treatment with anti-factor xi/xia antibodies

Related Child Applications (1)

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JP2022115212A Division JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2020504110A JP2020504110A (ja) 2020-02-06
JP2020504110A5 JP2020504110A5 (enExample) 2021-04-30
JP7110199B2 true JP7110199B2 (ja) 2022-08-01

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JP2019533396A Active JP7110199B2 (ja) 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Active JP7864156B2 (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Active JP7864156B2 (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Country Status (9)

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US (3) US20200231701A1 (enExample)
EP (2) EP4759361A2 (enExample)
JP (3) JP7110199B2 (enExample)
KR (3) KR102918597B1 (enExample)
CN (2) CN118320078A (enExample)
AU (2) AU2017383537B2 (enExample)
CA (1) CA3048157A1 (enExample)
IL (2) IL267519B2 (enExample)
WO (1) WO2018116267A2 (enExample)

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RU2021125449A (ru) 2014-10-01 2021-09-16 Медиммьюн Лимитед Антитела к тикагрелору и способы применения
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TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
KR102616666B1 (ko) 2016-12-23 2023-12-27 노파르티스 아게 인자 xi 항체 및 사용 방법
CN118320078A (zh) * 2016-12-23 2024-07-12 诺华股份有限公司 采用抗因子XI/XIa抗体治疗的方法
EP3852617B1 (en) * 2018-09-20 2025-09-10 SFJ Pharma X, Inc. Use of antibody fragments for reversing ticagrelor activity
US12703762B2 (en) 2018-12-18 2026-08-11 Novartis Ag Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof
EP3957652A4 (en) * 2019-04-16 2023-06-21 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Anti-fxi/fxia antibody and use thereof
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
JP2023507795A (ja) * 2019-12-20 2023-02-27 アントス セラピューティクス， インコーポレイテッド 第ＸＩ／ＸＩａ因子抗体の医薬製剤および投薬レジメン
BR112022026533A2 (pt) * 2020-07-02 2023-01-17 Beijing Tuo Jie Biopharmaceutical Co Ltd Anticorpo anti-fxi/fxia, fragmento de ligação do mesmo, e antígenos e uso farmacêutico do mesmo
TW202405022A (zh) * 2022-06-24 2024-02-01 美商安瑟斯治療公司 與抗因子ｘｉ／因子ｘｉａ抗體之組合療法
CN120173947A (zh) * 2024-03-28 2025-06-20 施能康医药科技(苏州)有限公司 靶向凝血因子xi的核酸及其用途

Citations (2)

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JP2015517305A (ja) 2012-05-10 2015-06-22 バイエル ファーマ アクチエンゲゼルシャフト 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途
JP2018526976A (ja) 2015-06-26 2018-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法

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JP2018526976A (ja) 2015-06-26 2018-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法

Also Published As

Publication number Publication date
CA3048157A1 (en) 2018-06-28
KR20260023597A (ko) 2026-02-20
US20230002507A1 (en) 2023-01-05
CN110325211A (zh) 2019-10-11
US20200231701A1 (en) 2020-07-23
WO2018116267A3 (en) 2018-08-02
IL267519B2 (en) 2025-04-01
WO2018116267A2 (en) 2018-06-28
IL316673A (en) 2024-12-01
EP3558370A2 (en) 2019-10-30
JP2022141831A (ja) 2022-09-29
JP2024116221A (ja) 2024-08-27
AU2017383537A1 (en) 2019-06-27
KR102702288B1 (ko) 2024-09-05
IL267519B1 (en) 2024-12-01
JP7864156B2 (ja) 2026-05-22
AU2024287181A1 (en) 2025-03-06
US20250197522A1 (en) 2025-06-19
KR20190099256A (ko) 2019-08-26
JP2020504110A (ja) 2020-02-06
EP4759361A2 (en) 2026-06-17
KR102918597B1 (ko) 2026-01-28
KR20240134248A (ko) 2024-09-06
IL267519A (en) 2019-08-29
JP7500662B2 (ja) 2024-06-17
CN118320078A (zh) 2024-07-12
AU2017383537B2 (en) 2024-10-03

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