KR102899410B1 - 가교형 뉴클레오시드 중간체의 결정 및 그의 제조 방법, 그리고 가교형 뉴클레오시드 아미다이트의 제조 방법 - Google Patents

가교형 뉴클레오시드 중간체의 결정 및 그의 제조 방법, 그리고 가교형 뉴클레오시드 아미다이트의 제조 방법

Info

Publication number
KR102899410B1
KR102899410B1 KR1020227000752A KR20227000752A KR102899410B1 KR 102899410 B1 KR102899410 B1 KR 102899410B1 KR 1020227000752 A KR1020227000752 A KR 1020227000752A KR 20227000752 A KR20227000752 A KR 20227000752A KR 102899410 B1 KR102899410 B1 KR 102899410B1
Authority
KR
South Korea
Prior art keywords
formula
group
compound represented
compound
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020227000752A
Other languages
English (en)
Korean (ko)
Other versions
KR20220024461A (ko
Inventor
사토루 고고
Original Assignee
야마사 쇼유 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 야마사 쇼유 가부시키가이샤 filed Critical 야마사 쇼유 가부시키가이샤
Publication of KR20220024461A publication Critical patent/KR20220024461A/ko
Application granted granted Critical
Publication of KR102899410B1 publication Critical patent/KR102899410B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227000752A 2019-06-19 2020-06-18 가교형 뉴클레오시드 중간체의 결정 및 그의 제조 방법, 그리고 가교형 뉴클레오시드 아미다이트의 제조 방법 Active KR102899410B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2019-113372 2019-06-19
JP2019113372 2019-06-19
PCT/JP2020/024037 WO2020256084A1 (ja) 2019-06-19 2020-06-18 架橋型ヌクレオシド中間体の結晶及びその製造方法、並びに架橋型ヌクレオシドアミダイトの製造方法

Publications (2)

Publication Number Publication Date
KR20220024461A KR20220024461A (ko) 2022-03-03
KR102899410B1 true KR102899410B1 (ko) 2025-12-12

Family

ID=74040857

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227000752A Active KR102899410B1 (ko) 2019-06-19 2020-06-18 가교형 뉴클레오시드 중간체의 결정 및 그의 제조 방법, 그리고 가교형 뉴클레오시드 아미다이트의 제조 방법

Country Status (7)

Country Link
US (1) US12173023B2 (enExample)
EP (1) EP3988558A4 (enExample)
JP (2) JPWO2020256084A1 (enExample)
KR (1) KR102899410B1 (enExample)
CN (1) CN113924308B (enExample)
CA (1) CA3142593C (enExample)
WO (1) WO2020256084A1 (enExample)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
DE69829760T3 (de) 1997-09-12 2016-04-14 Exiqon A/S Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
TR200102328T2 (tr) 1999-02-12 2002-01-21 Sankyo Company Limited Yeni nükleosid ve oligonükleotid analogları
JP6048982B2 (ja) * 2012-09-21 2016-12-21 国立大学法人大阪大学 グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド
EP2970968B1 (en) * 2013-03-15 2018-01-10 Miragen Therapeutics, Inc. Bridged bicyclic nucleosides
CN107428793A (zh) * 2015-04-02 2017-12-01 株式会社博纳克 配糖体化合物的制造方法

Also Published As

Publication number Publication date
CA3142593A1 (en) 2020-12-24
JP2024169733A (ja) 2024-12-05
CN113924308A (zh) 2022-01-11
US20220315617A1 (en) 2022-10-06
JPWO2020256084A1 (enExample) 2020-12-24
EP3988558A1 (en) 2022-04-27
KR20220024461A (ko) 2022-03-03
CA3142593C (en) 2025-05-20
US12173023B2 (en) 2024-12-24
EP3988558A4 (en) 2022-09-28
CN113924308B (zh) 2024-09-13
WO2020256084A1 (ja) 2020-12-24

Similar Documents

Publication Publication Date Title
JP4476802B2 (ja) ロックト核酸誘導体の製造
JP4768132B2 (ja) ［２．２．１］ビシクロヌクレオシドの改良された製法
EP1594882B1 (en) Process for preparing branched ribonucleosides from 1, 2-anhydroribofuranose intermediates
NZ540913A (en) Process for the production of 3'-nucleoside prodrugs
US5672698A (en) Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
WO2020032152A1 (ja) ４'－置換ヌクレオシド誘導体の立体選択的合成法
KR102899410B1 (ko) 가교형 뉴클레오시드 중간체의 결정 및 그의 제조 방법, 그리고 가교형 뉴클레오시드 아미다이트의 제조 방법
JP7478660B2 (ja) 修飾ヌクレオシドホスホロアミダイト
JP2023517735A (ja) オキシム中間体及び関連化合物を介した３’ｎヌクレオシドの合成
CN109503689B (zh) 一种制备瓜德希他滨及其中间体的方法
JP2022532875A (ja) Ｃｒａｃチャネル阻害剤の合成
CN119161348B (zh) 一种依鲁替尼及其合成方法
JP2004175791A (ja) ３’，５’−ｏ−スルフィニルキシロシチジン誘導体、その製造方法及びシチジン化合物の製造方法
US20030236397A1 (en) Process for preparing beta-L-2'deoxy-thymidine
EP1258489B1 (en) Method for purifying 5'-protected thymidines
JP4174895B2 (ja) ヌクレオシド誘導体とその製法
CN102020658B (zh) 2-氯-6，8-二氢-5H-咪唑[2，1-c]-[1，4]噁嗪及其制备方法
JPWO2010079813A1 (ja) イノシン誘導体の製造方法
JP4424900B2 (ja) ５’−ｏ−置換チミジンの精製法
CN118852301A (zh) 一种3′-o-甲酰基核苷衍生物的制备方法
CN120418261A (zh) 制造中间体的制造方法、该制造中间体及使用其的桥连型人工核酸中间体的制造方法
CN119431334A (zh) 2’OMe修饰的假尿苷和N1甲基假尿苷的制备方法
CN101220031A (zh) 无环嘌呤核苷衍生物及其制备方法
JP2004175792A (ja) ３’，５’−Ｏ−スルフィニルキシロウリジン誘導体、その製造方法及び２，２’−アンヒドロ−１−（β−Ｄ−アラビノフラノシル）ウラシル化合物の製造方法
CN110511258A (zh) 一种胞嘧啶核苷的制备方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D22-EXM-PE0701 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

F11 Ip right granted following substantive examination

Free format text: ST27 STATUS EVENT CODE: A-2-4-F10-F11-EXM-PR0701 (AS PROVIDED BY THE NATIONAL OFFICE)

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

U12 Designation fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U12-OTH-PR1002 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

Q13 Ip right document published

Free format text: ST27 STATUS EVENT CODE: A-4-4-Q10-Q13-NAP-PG1601 (AS PROVIDED BY THE NATIONAL OFFICE)