CN113924308B - 交联型核苷中间体的结晶及其制造方法以及交联型核苷亚磷酰胺的制造方法 - Google Patents

交联型核苷中间体的结晶及其制造方法以及交联型核苷亚磷酰胺的制造方法 Download PDF

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CN113924308B
CN113924308B CN202080040731.2A CN202080040731A CN113924308B CN 113924308 B CN113924308 B CN 113924308B CN 202080040731 A CN202080040731 A CN 202080040731A CN 113924308 B CN113924308 B CN 113924308B
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CN113924308A (zh
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向后悟
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Yamasa Corp
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Yamasa Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202080040731.2A 2019-06-19 2020-06-18 交联型核苷中间体的结晶及其制造方法以及交联型核苷亚磷酰胺的制造方法 Active CN113924308B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-113372 2019-06-19
JP2019113372 2019-06-19
PCT/JP2020/024037 WO2020256084A1 (ja) 2019-06-19 2020-06-18 架橋型ヌクレオシド中間体の結晶及びその製造方法、並びに架橋型ヌクレオシドアミダイトの製造方法

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CN113924308A CN113924308A (zh) 2022-01-11
CN113924308B true CN113924308B (zh) 2024-09-13

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CN202080040731.2A Active CN113924308B (zh) 2019-06-19 2020-06-18 交联型核苷中间体的结晶及其制造方法以及交联型核苷亚磷酰胺的制造方法

Country Status (7)

Country Link
US (1) US12173023B2 (enExample)
EP (1) EP3988558A4 (enExample)
JP (2) JPWO2020256084A1 (enExample)
KR (1) KR102899410B1 (enExample)
CN (1) CN113924308B (enExample)
CA (1) CA3142593C (enExample)
WO (1) WO2020256084A1 (enExample)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
DE69829760T3 (de) 1997-09-12 2016-04-14 Exiqon A/S Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
TR200102328T2 (tr) 1999-02-12 2002-01-21 Sankyo Company Limited Yeni nükleosid ve oligonükleotid analogları
JP6048982B2 (ja) * 2012-09-21 2016-12-21 国立大学法人大阪大学 グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド
EP2970968B1 (en) * 2013-03-15 2018-01-10 Miragen Therapeutics, Inc. Bridged bicyclic nucleosides
CN107428793A (zh) * 2015-04-02 2017-12-01 株式会社博纳克 配糖体化合物的制造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Fukuyama,KEI.Development of Efficient Synthetic Methods for C4-Tetrasubstrituted Nucleoside Derivatives with Pharmacological Activites.《Tohoku University Doctoral Dissertation》.2016,第1-102页. *

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Publication number Publication date
CA3142593A1 (en) 2020-12-24
JP2024169733A (ja) 2024-12-05
CN113924308A (zh) 2022-01-11
US20220315617A1 (en) 2022-10-06
JPWO2020256084A1 (enExample) 2020-12-24
EP3988558A1 (en) 2022-04-27
KR20220024461A (ko) 2022-03-03
CA3142593C (en) 2025-05-20
US12173023B2 (en) 2024-12-24
EP3988558A4 (en) 2022-09-28
KR102899410B1 (ko) 2025-12-12
WO2020256084A1 (ja) 2020-12-24

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