CA3142593C - Cross-linked nucleoside intermediate crystal and its manufacturing method, and manufacturing method of cross-linked nucleoside amidite - Google Patents

Cross-linked nucleoside intermediate crystal and its manufacturing method, and manufacturing method of cross-linked nucleoside amidite

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Publication number
CA3142593C
CA3142593C CA3142593A CA3142593A CA3142593C CA 3142593 C CA3142593 C CA 3142593C CA 3142593 A CA3142593 A CA 3142593A CA 3142593 A CA3142593 A CA 3142593A CA 3142593 C CA3142593 C CA 3142593C
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Canada
Prior art keywords
formula
compound represented
compound
group
crystal
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Application number
CA3142593A
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English (en)
French (fr)
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CA3142593A1 (en
Inventor
Satoru Kohgo
Original Assignee
Yamasa Corp
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Publication of CA3142593A1 publication Critical patent/CA3142593A1/en
Application granted granted Critical
Publication of CA3142593C publication Critical patent/CA3142593C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3142593A 2019-06-19 2020-06-18 Cross-linked nucleoside intermediate crystal and its manufacturing method, and manufacturing method of cross-linked nucleoside amidite Active CA3142593C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-113372 2019-06-19
JP2019113372 2019-06-19
PCT/JP2020/024037 WO2020256084A1 (ja) 2019-06-19 2020-06-18 架橋型ヌクレオシド中間体の結晶及びその製造方法、並びに架橋型ヌクレオシドアミダイトの製造方法

Publications (2)

Publication Number Publication Date
CA3142593A1 CA3142593A1 (en) 2020-12-24
CA3142593C true CA3142593C (en) 2025-05-20

Family

ID=74040857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3142593A Active CA3142593C (en) 2019-06-19 2020-06-18 Cross-linked nucleoside intermediate crystal and its manufacturing method, and manufacturing method of cross-linked nucleoside amidite

Country Status (7)

Country Link
US (1) US12173023B2 (enExample)
EP (1) EP3988558A4 (enExample)
JP (2) JPWO2020256084A1 (enExample)
KR (1) KR102899410B1 (enExample)
CN (1) CN113924308B (enExample)
CA (1) CA3142593C (enExample)
WO (1) WO2020256084A1 (enExample)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
DE69829760T3 (de) 1997-09-12 2016-04-14 Exiqon A/S Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
TR200102328T2 (tr) 1999-02-12 2002-01-21 Sankyo Company Limited Yeni nükleosid ve oligonükleotid analogları
JP6048982B2 (ja) * 2012-09-21 2016-12-21 国立大学法人大阪大学 グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド
EP2970968B1 (en) * 2013-03-15 2018-01-10 Miragen Therapeutics, Inc. Bridged bicyclic nucleosides
CN107428793A (zh) * 2015-04-02 2017-12-01 株式会社博纳克 配糖体化合物的制造方法

Also Published As

Publication number Publication date
CA3142593A1 (en) 2020-12-24
JP2024169733A (ja) 2024-12-05
CN113924308A (zh) 2022-01-11
US20220315617A1 (en) 2022-10-06
JPWO2020256084A1 (enExample) 2020-12-24
EP3988558A1 (en) 2022-04-27
KR20220024461A (ko) 2022-03-03
US12173023B2 (en) 2024-12-24
EP3988558A4 (en) 2022-09-28
CN113924308B (zh) 2024-09-13
KR102899410B1 (ko) 2025-12-12
WO2020256084A1 (ja) 2020-12-24

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