KR102894596B1 - Snca 발현을 감소시키기 위한 화합물 및 방법 - Google Patents

Snca 발현을 감소시키기 위한 화합물 및 방법

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KR102894596B1
KR102894596B1 KR1020207016043A KR20207016043A KR102894596B1 KR 102894596 B1 KR102894596 B1 KR 102894596B1 KR 1020207016043 A KR1020207016043 A KR 1020207016043A KR 20207016043 A KR20207016043 A KR 20207016043A KR 102894596 B1 KR102894596 B1 KR 102894596B1
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modified
seq
certain embodiments
delete delete
nucleobase
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KR20200079304A (ko
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홀리 코르다지에빅츠
프리얌 싱
수잔 엠. 프레이어
트레이시 에이. 콜
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아이오니스 파마수티컬즈, 인코포레이티드
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    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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KR1020207016043A 2017-11-09 2018-11-09 Snca 발현을 감소시키기 위한 화합물 및 방법 Active KR102894596B1 (ko)

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KR1020257039904A KR20250174996A (ko) 2017-11-09 2018-11-09 Snca 발현을 감소시키기 위한 화합물 및 방법

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US201762584009P 2017-11-09 2017-11-09
US62/584,009 2017-11-09
PCT/US2018/060097 WO2019164562A2 (en) 2017-11-09 2018-11-09 Compounds and methods for reducing snca expression

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KR102894596B1 true KR102894596B1 (ko) 2025-12-04

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KR1020257039904A Pending KR20250174996A (ko) 2017-11-09 2018-11-09 Snca 발현을 감소시키기 위한 화합물 및 방법

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EP (2) EP4434585B1 (https=)
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KR (2) KR102894596B1 (https=)
CN (2) CN111373043B (https=)
AR (1) AR113870A1 (https=)
AU (2) AU2018409843B2 (https=)
BR (1) BR112020007240A2 (https=)
CA (1) CA3078788A1 (https=)
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PH (1) PH12020550586A1 (https=)
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CA2817960C (en) 2010-11-17 2020-06-09 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
CA3056563C (en) 2017-03-17 2023-03-14 Meiji Seika Pharma Co., Ltd. Plant disease control agent
IL269517B2 (en) 2017-04-05 2025-01-01 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of a target gene in a cell, conjugates thereof, compositions containing them, and medical uses thereof
TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
SG11202006528XA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CN120310791A (zh) 2018-01-12 2025-07-15 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
CN120505310A (zh) * 2020-02-28 2025-08-19 Ionis制药公司 用于调节smn2的化合物和方法
WO2022189363A1 (en) * 2021-03-08 2022-09-15 Les Laboratoires Servier Antisense oligonucleotides for inhibiting alpha-synuclein expression
EP4342988A1 (en) * 2022-09-20 2024-03-27 Eberhard Karls Universität Tübingen, Medizinische Fakultät Compositions and methods for modification of the expression of a snca gene
JP2025532127A (ja) * 2022-09-23 2025-09-29 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｍｅｃｐ２発現を低減する化合物及び方法
WO2024166019A1 (en) * 2023-02-08 2024-08-15 Biorchestra Co., Ltd. Sirna targeting alpha-synuclein and uses thereof
WO2025063185A1 (ja) * 2023-09-19 2025-03-27 国立大学法人東海国立大学機構 １本鎖ポリヌクレオチド
TW202528540A (zh) * 2023-09-20 2025-07-16 日商第一三共股份有限公司 抑制α-突觸核蛋白之表現的siRNA

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TWI809004B (zh) 2023-07-21
JP2023011725A (ja) 2023-01-24
UY37967A (es) 2019-05-31
US20220315923A1 (en) 2022-10-06
BR112020007240A2 (pt) 2020-10-13
AR113870A1 (es) 2020-06-24
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