KR102713354B1 - 선택적 p2x3 조정제 - Google Patents

선택적 p2x3 조정제 Download PDF

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Publication number
KR102713354B1
KR102713354B1 KR1020207010982A KR20207010982A KR102713354B1 KR 102713354 B1 KR102713354 B1 KR 102713354B1 KR 1020207010982 A KR1020207010982 A KR 1020207010982A KR 20207010982 A KR20207010982 A KR 20207010982A KR 102713354 B1 KR102713354 B1 KR 102713354B1
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selective
antagonist
patient
receptor antagonism
compound
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Korean (ko)
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KR20200092938A (ko
Inventor
데니스 게르소
안토니오스 마트조우라니스
로베르토 벨리니
케말 페이자
나탈리 차우렛
수잔 이. 브라운
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 3) 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Amplifiers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
KR1020207010982A 2017-09-18 2018-09-14 선택적 p2x3 조정제 Active KR102713354B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762560077P 2017-09-18 2017-09-18
US62/560,077 2017-09-18
US15/936,316 US10111883B1 (en) 2017-09-18 2018-03-26 Selective P2X3 modulators
US15/936,316 2018-03-26
PCT/IB2018/001513 WO2019064079A2 (en) 2017-09-18 2018-09-14 SELECTIVE MODULATORS OF P2X3

Publications (2)

Publication Number Publication Date
KR20200092938A KR20200092938A (ko) 2020-08-04
KR102713354B1 true KR102713354B1 (ko) 2024-10-02

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ID=63894683

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Application Number Title Priority Date Filing Date
KR1020207010982A Active KR102713354B1 (ko) 2017-09-18 2018-09-14 선택적 p2x3 조정제

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Country Link
US (6) US10111883B1 (https=)
EP (2) EP3684368B8 (https=)
JP (1) JP7242681B2 (https=)
KR (1) KR102713354B1 (https=)
CN (1) CN111601601A (https=)
AU (1) AU2018342751B2 (https=)
CA (1) CA3076150C (https=)
ES (1) ES2969868T3 (https=)
IL (2) IL303257A (https=)
MX (1) MX2020002968A (https=)
SG (1) SG11202002460QA (https=)
WO (1) WO2019064079A2 (https=)

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CN113559104A (zh) * 2018-10-05 2021-10-29 盐野义制药株式会社 慢性咳嗽治疗用药物
CA3115939A1 (en) * 2018-10-10 2020-04-16 Bellus Health Cough Inc. Treatment of pruritus with p2x3 antagonists
MX2021005424A (es) * 2018-11-13 2021-06-15 Bellus Health Cough Inc Formas cristalinas de un compuesto de imidazopiridina sustituida y uso del mismo como modulador del receptor p2x3.
WO2020135771A1 (zh) * 2018-12-29 2020-07-02 武汉朗来科技发展有限公司 杂环类化合物、中间体、其制备方法及应用
AU2020228760A1 (en) * 2019-02-25 2021-09-23 Glaxosmithkline Intellectual Property (No. 3) Limited Treatment with P2X3 modulators
CN112409331B (zh) * 2019-08-21 2024-02-20 上海翰森生物医药科技有限公司 杂环类衍生物抑制剂、其制备方法和应用
EP4103572A4 (en) 2020-02-14 2024-03-06 Bellus Health Cough Inc. MAKING A P2X3 ANTAGONIST
JP2023513373A (ja) * 2020-02-14 2023-03-30 べルス・ヘルス・コフ・インコーポレーテッド Ｐ２ｘ３修飾薬
MX2022013499A (es) 2020-04-27 2023-01-16 Twist Bioscience Corp Bibliotecas de ácidos nucleicos variantes para coronavirus.
WO2021244634A1 (zh) * 2020-06-05 2021-12-09 武汉人福创新药物研发中心有限公司 咪唑并吡啶类化合物及其用途
CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
AU2021302056B2 (en) * 2020-06-29 2023-12-14 Wuhan Ll Science And Technology Development Co., Ltd. Crystalline form of heterocyclic compound, preparation method therefor and application thereof
US20230218661A1 (en) * 2022-01-10 2023-07-13 Sensory Cloud, Inc. Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx
US20240408131A1 (en) * 2020-07-06 2024-12-12 Sensory Cloud, Inc. Isotonic or hypertonic salt-based compositions
CN113912601B (zh) * 2020-07-10 2023-06-06 上海拓界生物医药科技有限公司 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途
EP4198034A4 (en) * 2020-08-13 2024-01-17 Tuojie Biotech (Shanghai) Co., Ltd. BENZIMIDAZOLE DERIVATIVES, PRODUCTION PROCESS THEREOF AND MEDICAL USE THEREOF
CN116635389A (zh) * 2021-01-29 2023-08-22 上海海雁医药科技有限公司 吗啉衍生物及其药物组合物和用途
WO2022258059A1 (zh) * 2021-06-10 2022-12-15 武汉朗来科技发展有限公司 一种药物组合物、制剂及其制备方法和应用
CN115043836B (zh) * 2021-08-20 2023-07-18 苏州璞正医药有限公司 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途
CN120917022A (zh) 2023-03-23 2025-11-07 葛兰素史密斯克莱知识产权(第3号)有限公司 氘代p2x3调节剂
WO2026022326A1 (en) 2024-07-25 2026-01-29 Glaxosmithkline Intellectual Property (No.3) Limited P2x3 antagonist formulation

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KR102120513B1 (ko) 2013-01-31 2020-06-08 네오메드 인스티튜트 이미다조피리딘 화합물 및 이의 용도

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BR112012011518B8 (pt) * 2009-11-18 2023-01-10 Astrazeneca Ab Compostos, composição farmacêutica, kit e usos de um composto
WO2011116392A2 (en) * 2010-03-19 2011-09-22 University Of Miami Use of p2x purinergic receptor agonists to enhance insulin secretion in pancreatic beta cells
RU2650118C2 (ru) * 2013-08-23 2018-04-09 Афферент Фармасьютикалз Инк. Способ лечения острого, хронического и подострого кашля и непреодолимого желания откашляться
HUE058009T2 (hu) * 2014-12-09 2022-06-28 Bayer Ag 1,3-Tiazol-2-il szubsztituált benzamid-származékok
KR20180054843A (ko) * 2015-09-29 2018-05-24 애퍼런트 파마슈티컬스 인크. 기침 치료에 사용하기 위한 디아미노피리미딘 p2x3 및 p2x2/3 수용체 조정제
US9907795B2 (en) * 2016-01-08 2018-03-06 Nerre Therapeutics Limited Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents
CN109996546B (zh) * 2016-09-30 2023-06-27 阿沙纳生物科学公司 P2x3和/或p2x2/3化合物及方法

Patent Citations (1)

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KR102120513B1 (ko) 2013-01-31 2020-06-08 네오메드 인스티튜트 이미다조피리딘 화합물 및 이의 용도

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ES2969868T3 (es) 2024-05-23
CA3076150A1 (en) 2019-04-04
MX2020002968A (es) 2020-08-17
CA3076150C (en) 2024-01-02
EP3684368A2 (en) 2020-07-29
EP3684368B1 (en) 2024-01-03
EP3684368A4 (en) 2021-05-26
EP3684368B8 (en) 2024-02-14
US20230248736A1 (en) 2023-08-10
JP2020534355A (ja) 2020-11-26
IL273348B2 (en) 2023-11-01
IL273348A (en) 2020-05-31
SG11202002460QA (en) 2020-04-29
IL303257A (en) 2023-07-01
KR20200092938A (ko) 2020-08-04
US10111883B1 (en) 2018-10-30
EP4331669A3 (en) 2024-05-01
US20200230148A1 (en) 2020-07-23
IL273348B1 (en) 2023-07-01
US20210322432A1 (en) 2021-10-21
AU2018342751B2 (en) 2023-06-15
EP4331669A2 (en) 2024-03-06
US20210069201A1 (en) 2021-03-11
WO2019064079A3 (en) 2019-05-16
CN111601601A (zh) 2020-08-28
AU2018342751A1 (en) 2020-04-23
US20220160724A1 (en) 2022-05-26
WO2019064079A2 (en) 2019-04-04
JP7242681B2 (ja) 2023-03-20

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