IL303257A - Selective p2x3 modulators - Google Patents
Selective p2x3 modulatorsInfo
- Publication number
- IL303257A IL303257A IL303257A IL30325723A IL303257A IL 303257 A IL303257 A IL 303257A IL 303257 A IL303257 A IL 303257A IL 30325723 A IL30325723 A IL 30325723A IL 303257 A IL303257 A IL 303257A
- Authority
- IL
- Israel
- Prior art keywords
- selective
- antagonist
- receptor antagonism
- patient
- compound
- Prior art date
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Amplifiers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
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| PCT/IB2018/001513 WO2019064079A2 (en) | 2017-09-18 | 2018-09-14 | SELECTIVE MODULATORS OF P2X3 |
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| CA3115939A1 (en) * | 2018-10-10 | 2020-04-16 | Bellus Health Cough Inc. | Treatment of pruritus with p2x3 antagonists |
| MX2021005424A (es) * | 2018-11-13 | 2021-06-15 | Bellus Health Cough Inc | Formas cristalinas de un compuesto de imidazopiridina sustituida y uso del mismo como modulador del receptor p2x3. |
| WO2020135771A1 (zh) * | 2018-12-29 | 2020-07-02 | 武汉朗来科技发展有限公司 | 杂环类化合物、中间体、其制备方法及应用 |
| AU2020228760A1 (en) * | 2019-02-25 | 2021-09-23 | Glaxosmithkline Intellectual Property (No. 3) Limited | Treatment with P2X3 modulators |
| CN112409331B (zh) * | 2019-08-21 | 2024-02-20 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| EP4103572A4 (en) | 2020-02-14 | 2024-03-06 | Bellus Health Cough Inc. | MAKING A P2X3 ANTAGONIST |
| JP2023513373A (ja) * | 2020-02-14 | 2023-03-30 | べルス・ヘルス・コフ・インコーポレーテッド | Ｐ２ｘ３修飾薬 |
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| WO2021244634A1 (zh) * | 2020-06-05 | 2021-12-09 | 武汉人福创新药物研发中心有限公司 | 咪唑并吡啶类化合物及其用途 |
| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
| AU2021302056B2 (en) * | 2020-06-29 | 2023-12-14 | Wuhan Ll Science And Technology Development Co., Ltd. | Crystalline form of heterocyclic compound, preparation method therefor and application thereof |
| US20230218661A1 (en) * | 2022-01-10 | 2023-07-13 | Sensory Cloud, Inc. | Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx |
| US20240408131A1 (en) * | 2020-07-06 | 2024-12-12 | Sensory Cloud, Inc. | Isotonic or hypertonic salt-based compositions |
| CN113912601B (zh) * | 2020-07-10 | 2023-06-06 | 上海拓界生物医药科技有限公司 | 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途 |
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| CN116635389A (zh) * | 2021-01-29 | 2023-08-22 | 上海海雁医药科技有限公司 | 吗啉衍生物及其药物组合物和用途 |
| WO2022258059A1 (zh) * | 2021-06-10 | 2022-12-15 | 武汉朗来科技发展有限公司 | 一种药物组合物、制剂及其制备方法和应用 |
| CN115043836B (zh) * | 2021-08-20 | 2023-07-18 | 苏州璞正医药有限公司 | 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途 |
| CN120917022A (zh) | 2023-03-23 | 2025-11-07 | 葛兰素史密斯克莱知识产权(第3号)有限公司 | 氘代p2x3调节剂 |
| WO2026022326A1 (en) | 2024-07-25 | 2026-01-29 | Glaxosmithkline Intellectual Property (No.3) Limited | P2x3 antagonist formulation |
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| WO2011116392A2 (en) * | 2010-03-19 | 2011-09-22 | University Of Miami | Use of p2x purinergic receptor agonists to enhance insulin secretion in pancreatic beta cells |
| US9598409B2 (en) * | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| RU2650118C2 (ru) * | 2013-08-23 | 2018-04-09 | Афферент Фармасьютикалз Инк. | Способ лечения острого, хронического и подострого кашля и непреодолимого желания откашляться |
| HUE058009T2 (hu) * | 2014-12-09 | 2022-06-28 | Bayer Ag | 1,3-Tiazol-2-il szubsztituált benzamid-származékok |
| KR20180054843A (ko) * | 2015-09-29 | 2018-05-24 | 애퍼런트 파마슈티컬스 인크. | 기침 치료에 사용하기 위한 디아미노피리미딘 p2x3 및 p2x2/3 수용체 조정제 |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| CN109996546B (zh) * | 2016-09-30 | 2023-06-27 | 阿沙纳生物科学公司 | P2x3和/或p2x2/3化合物及方法 |
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2018
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- 2018-09-14 JP JP2020537064A patent/JP7242681B2/ja active Active
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- 2018-09-14 AU AU2018342751A patent/AU2018342751B2/en active Active
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- 2018-09-14 IL IL303257A patent/IL303257A/en unknown
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- 2018-09-14 MX MX2020002968A patent/MX2020002968A/es unknown
- 2018-09-14 EP EP18860273.4A patent/EP3684368B8/en active Active
- 2018-09-14 EP EP23219770.7A patent/EP4331669A3/en active Pending
- 2018-09-14 ES ES18860273T patent/ES2969868T3/es active Active
- 2018-09-14 WO PCT/IB2018/001513 patent/WO2019064079A2/en not_active Ceased
- 2018-09-14 IL IL273348A patent/IL273348B2/en unknown
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2021
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| ES2969868T3 (es) | 2024-05-23 |
| CA3076150A1 (en) | 2019-04-04 |
| MX2020002968A (es) | 2020-08-17 |
| KR102713354B1 (ko) | 2024-10-02 |
| CA3076150C (en) | 2024-01-02 |
| EP3684368A2 (en) | 2020-07-29 |
| EP3684368B1 (en) | 2024-01-03 |
| EP3684368A4 (en) | 2021-05-26 |
| EP3684368B8 (en) | 2024-02-14 |
| US20230248736A1 (en) | 2023-08-10 |
| JP2020534355A (ja) | 2020-11-26 |
| IL273348B2 (en) | 2023-11-01 |
| IL273348A (en) | 2020-05-31 |
| SG11202002460QA (en) | 2020-04-29 |
| KR20200092938A (ko) | 2020-08-04 |
| US10111883B1 (en) | 2018-10-30 |
| EP4331669A3 (en) | 2024-05-01 |
| US20200230148A1 (en) | 2020-07-23 |
| IL273348B1 (en) | 2023-07-01 |
| US20210322432A1 (en) | 2021-10-21 |
| AU2018342751B2 (en) | 2023-06-15 |
| EP4331669A2 (en) | 2024-03-06 |
| US20210069201A1 (en) | 2021-03-11 |
| WO2019064079A3 (en) | 2019-05-16 |
| CN111601601A (zh) | 2020-08-28 |
| AU2018342751A1 (en) | 2020-04-23 |
| US20220160724A1 (en) | 2022-05-26 |
| WO2019064079A2 (en) | 2019-04-04 |
| JP7242681B2 (ja) | 2023-03-20 |
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