KR102699408B1 - 인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 - Google Patents
인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 Download PDFInfo
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- KR102699408B1 KR102699408B1 KR1020187009490A KR20187009490A KR102699408B1 KR 102699408 B1 KR102699408 B1 KR 102699408B1 KR 1020187009490 A KR1020187009490 A KR 1020187009490A KR 20187009490 A KR20187009490 A KR 20187009490A KR 102699408 B1 KR102699408 B1 KR 102699408B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Neurology (AREA)
- Oncology (AREA)
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- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214299P | 2015-09-04 | 2015-09-04 | |
| US62/214,299 | 2015-09-04 | ||
| PL415078A PL415078A1 (pl) | 2015-09-04 | 2015-12-04 | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
| PL415078 | 2015-12-04 | ||
| PCT/IB2016/055269 WO2017037670A1 (en) | 2015-09-04 | 2016-09-02 | Substituted amino triazoles useful as human chitinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180080190A KR20180080190A (ko) | 2018-07-11 |
| KR102699408B1 true KR102699408B1 (ko) | 2024-08-28 |
Family
ID=58190067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187009490A Active KR102699408B1 (ko) | 2015-09-04 | 2016-09-02 | 인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US9944624B2 (https=) |
| EP (1) | EP3344616B1 (https=) |
| JP (2) | JP6859325B2 (https=) |
| KR (1) | KR102699408B1 (https=) |
| CN (1) | CN108290863B (https=) |
| AU (1) | AU2016314345B2 (https=) |
| CA (1) | CA2997382C (https=) |
| CL (1) | CL2018000564A1 (https=) |
| CO (1) | CO2018003484A2 (https=) |
| CY (1) | CY1121432T1 (https=) |
| DK (1) | DK3344616T3 (https=) |
| ES (1) | ES2717181T3 (https=) |
| HK (1) | HK1249510B (https=) |
| HR (1) | HRP20190223T1 (https=) |
| HU (1) | HUE042726T2 (https=) |
| IL (1) | IL257545B (https=) |
| LT (1) | LT3344616T (https=) |
| ME (1) | ME03308B (https=) |
| MX (1) | MX368674B (https=) |
| PE (1) | PE20181048A1 (https=) |
| PH (1) | PH12018500286A1 (https=) |
| PL (2) | PL415078A1 (https=) |
| PT (1) | PT3344616T (https=) |
| SA (1) | SA518391033B1 (https=) |
| SI (1) | SI3344616T1 (https=) |
| SM (1) | SMT201900172T1 (https=) |
| TR (1) | TR201903826T4 (https=) |
| WO (1) | WO2017037670A1 (https=) |
| ZA (1) | ZA201801978B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN09346A (https=) | 2012-06-13 | 2015-07-17 | Hoffmann La Roche | |
| KR102179599B1 (ko) | 2012-09-25 | 2020-11-19 | 에프. 호프만-라 로슈 아게 | 이환형 유도체 |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| CN105764905B (zh) | 2013-11-26 | 2019-06-07 | 豪夫迈·罗氏有限公司 | 新的八氢-环丁二烯并[1,2-c;3,4-c’]二吡咯-2基 |
| WO2015144609A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| CN106103446B (zh) | 2014-03-26 | 2019-07-30 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
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| SG11201908560SA (en) | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| CN109503449A (zh) * | 2018-12-17 | 2019-03-22 | 天津药明康德新药开发有限公司 | 一种3-硝基吖丁啶-1-甲酸叔丁酯的合成方法 |
| AU2020313312A1 (en) | 2019-07-15 | 2022-03-03 | Oncoarendi Therapeutics S.A. | Substituted amino triazoles useful as chitinase inhibitors |
| IL291569B2 (en) * | 2019-09-25 | 2025-04-01 | Oncoarendi Therapeutics Sa | Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-4,2,1-triazol-3-amine |
| EP3854789A1 (en) | 2020-01-22 | 2021-07-28 | Cygnet Biosciences B.V. | Macrocyclic compounds useful as chitinase inhibitors |
| CN114057714B (zh) * | 2021-11-22 | 2023-07-14 | 苏州健雄职业技术学院 | 杂环基取代的氨基三唑的衍生物及其应用 |
| US12325701B2 (en) * | 2022-03-04 | 2025-06-10 | Molecure S.A. | YKL-40 inhibitors and their therapeutic |
| CN116924985B (zh) * | 2022-03-29 | 2026-03-17 | 山东新时代药业有限公司 | 一种法舒地尔的制备方法 |
| EP4269400B1 (en) * | 2022-04-29 | 2025-07-09 | Molecure SA | Ykl-40 inhibitors and their therapeutic applications |
| CN114957098B (zh) * | 2022-06-02 | 2024-03-29 | 和鼎(南京)医药技术有限公司 | 一种制备喷他佐辛中间体的方法 |
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| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US9440953B2 (en) * | 2014-12-19 | 2016-09-13 | OncoArendi Therapeutics Sp. z o.o. | Substituted amino triazoles useful as acidic mammalian chitinase inhibitors |
| PL415078A1 (pl) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
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