KR102699408B1 - 인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 - Google Patents

인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 Download PDF

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KR102699408B1
KR102699408B1 KR1020187009490A KR20187009490A KR102699408B1 KR 102699408 B1 KR102699408 B1 KR 102699408B1 KR 1020187009490 A KR1020187009490 A KR 1020187009490A KR 20187009490 A KR20187009490 A KR 20187009490A KR 102699408 B1 KR102699408 B1 KR 102699408B1
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KR20180080190A (ko
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마제라 마주르
로버츠 코랄렙스키
바르틀로미어 보레크
실비아 올리에니차크
보이치에흐 제이. 체스트코프스키
미갈 씨. 피에트로비츠
야체크 피. 오자크
아담 에이. 골비아우스키
아그니에시카 바르토세비쵸
엘즈비에타 풀루타
미갈 엘. 코왈스키
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몰큐어 에스.에이.
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KR1020187009490A 2015-09-04 2016-09-02 인간 키티나제 저해제로서 유용한 치환된 아미노트라이아졸 Active KR102699408B1 (ko)

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Application Number Priority Date Filing Date Title
US201562214299P 2015-09-04 2015-09-04
US62/214,299 2015-09-04
PL415078A PL415078A1 (pl) 2015-09-04 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
PL415078 2015-12-04
PCT/IB2016/055269 WO2017037670A1 (en) 2015-09-04 2016-09-02 Substituted amino triazoles useful as human chitinase inhibitors

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KR20180080190A KR20180080190A (ko) 2018-07-11
KR102699408B1 true KR102699408B1 (ko) 2024-08-28

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IN2014DN09346A (https=) 2012-06-13 2015-07-17 Hoffmann La Roche
KR102179599B1 (ko) 2012-09-25 2020-11-19 에프. 호프만-라 로슈 아게 이환형 유도체
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN105764905B (zh) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 新的八氢-环丁二烯并[1,2-c;3,4-c’]二吡咯-2基
WO2015144609A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
CN106103446B (zh) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
PL415078A1 (pl) 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
AU2016328365B2 (en) 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
KR20180054830A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서의 이환형 화합물
RU2018112230A (ru) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов atx
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
SG11201908560SA (en) 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
CN109503449A (zh) * 2018-12-17 2019-03-22 天津药明康德新药开发有限公司 一种3-硝基吖丁啶-1-甲酸叔丁酯的合成方法
AU2020313312A1 (en) 2019-07-15 2022-03-03 Oncoarendi Therapeutics S.A. Substituted amino triazoles useful as chitinase inhibitors
IL291569B2 (en) * 2019-09-25 2025-04-01 Oncoarendi Therapeutics Sa Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-4,2,1-triazol-3-amine
EP3854789A1 (en) 2020-01-22 2021-07-28 Cygnet Biosciences B.V. Macrocyclic compounds useful as chitinase inhibitors
CN114057714B (zh) * 2021-11-22 2023-07-14 苏州健雄职业技术学院 杂环基取代的氨基三唑的衍生物及其应用
US12325701B2 (en) * 2022-03-04 2025-06-10 Molecure S.A. YKL-40 inhibitors and their therapeutic
CN116924985B (zh) * 2022-03-29 2026-03-17 山东新时代药业有限公司 一种法舒地尔的制备方法
EP4269400B1 (en) * 2022-04-29 2025-07-09 Molecure SA Ykl-40 inhibitors and their therapeutic applications
CN114957098B (zh) * 2022-06-02 2024-03-29 和鼎(南京)医药技术有限公司 一种制备喷他佐辛中间体的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095701A1 (en) 2013-12-20 2015-06-25 The Institute For Drug Delivery Substituted amino triazoles, and methods using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US9440953B2 (en) * 2014-12-19 2016-09-13 OncoArendi Therapeutics Sp. z o.o. Substituted amino triazoles useful as acidic mammalian chitinase inhibitors
PL415078A1 (pl) 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095701A1 (en) 2013-12-20 2015-06-25 The Institute For Drug Delivery Substituted amino triazoles, and methods using same

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