KR102628323B1 - 심장질환 예방 및 치료 방법 - Google Patents

심장질환 예방 및 치료 방법 Download PDF

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Publication number
KR102628323B1
KR102628323B1 KR1020197031562A KR20197031562A KR102628323B1 KR 102628323 B1 KR102628323 B1 KR 102628323B1 KR 1020197031562 A KR1020197031562 A KR 1020197031562A KR 20197031562 A KR20197031562 A KR 20197031562A KR 102628323 B1 KR102628323 B1 KR 102628323B1
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seq
antibody
variable region
delete delete
light chain
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KR20190131096A (ko
Inventor
앤소니 로센즈웨이그
제이슨 디. 로
데이비드 제이. 글라스
Original Assignee
노바르티스 아게
베쓰 이스라엘 디코니스 메디칼 센터 인크
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Priority to KR1020247002064A priority Critical patent/KR20240014600A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197031562A 2017-03-24 2018-03-20 심장질환 예방 및 치료 방법 Active KR102628323B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247002064A KR20240014600A (ko) 2017-03-24 2018-03-20 심장질환 예방 및 치료 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762476054P 2017-03-24 2017-03-24
US62/476,054 2017-03-24
PCT/US2018/023390 WO2018175460A1 (en) 2017-03-24 2018-03-20 Methods for preventing and treating heart disease

Related Child Applications (1)

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KR1020247002064A Division KR20240014600A (ko) 2017-03-24 2018-03-20 심장질환 예방 및 치료 방법

Publications (2)

Publication Number Publication Date
KR20190131096A KR20190131096A (ko) 2019-11-25
KR102628323B1 true KR102628323B1 (ko) 2024-01-22

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KR1020197031562A Active KR102628323B1 (ko) 2017-03-24 2018-03-20 심장질환 예방 및 치료 방법
KR1020247002064A Pending KR20240014600A (ko) 2017-03-24 2018-03-20 심장질환 예방 및 치료 방법

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Country Link
US (3) US10982000B2 (https=)
EP (2) EP4678660A3 (https=)
JP (2) JP7339159B2 (https=)
KR (2) KR102628323B1 (https=)
CN (2) CN119971025A (https=)
AU (1) AU2018240117B2 (https=)
CA (1) CA3054837A1 (https=)
DK (1) DK3600415T3 (https=)
ES (1) ES3054462T3 (https=)
FI (1) FI3600415T3 (https=)
HR (1) HRP20251505T1 (https=)
IL (1) IL269083B2 (https=)
LT (1) LT3600415T (https=)
PL (1) PL3600415T3 (https=)
PT (1) PT3600415T (https=)
RS (1) RS67504B1 (https=)
SI (1) SI3600415T1 (https=)
WO (1) WO2018175460A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3600415T3 (fi) 2017-03-24 2025-12-05 Novartis Ag Aktiviinireseptorin tyypin ii reseptorin vastainen vasta-aine käytettäväksi sydämen vajaatoiminnan hoidossa
AU2020284038A1 (en) * 2019-05-30 2021-12-02 Acceleron Pharma Inc. ActRII-binding proteins and uses thereof
EP4142769A4 (en) * 2020-04-28 2024-05-15 Acceleron Pharma Inc. ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
IL300362A (en) * 2020-08-20 2023-04-01 Regeneron Pharma Methods to prevent and treat poor cardiac function and covid-19 with activin A antagonists
TW202417505A (zh) * 2022-08-26 2024-05-01 美商維紗妮絲生物公司 Actrii抗體固定單位劑量治療
WO2025026353A1 (en) * 2023-08-01 2025-02-06 Laekna Therapeutics Shanghai Co., Ltd. Anti-acvr2b antibodies and uses thereof
WO2025183966A1 (en) 2024-02-28 2025-09-04 Versanis Bio, Inc. Actrii antibodies with extended half life

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JP7339159B2 (ja) 2023-09-05
EP4678660A2 (en) 2026-01-14
IL269083A (en) 2019-11-28
AU2018240117B2 (en) 2024-12-05
CN119971025A (zh) 2025-05-13
FI3600415T3 (fi) 2025-12-05
ES3054462T3 (en) 2026-02-03
PL3600415T3 (pl) 2026-02-16
IL269083B1 (en) 2024-08-01
CA3054837A1 (en) 2018-09-27
PT3600415T (pt) 2025-11-24
US20240158514A1 (en) 2024-05-16
US20200031940A1 (en) 2020-01-30
US20210309749A1 (en) 2021-10-07
IL269083B2 (en) 2024-12-01
HRP20251505T1 (hr) 2026-01-02
JP2023100919A (ja) 2023-07-19
RU2019129858A (ru) 2021-03-23
DK3600415T3 (da) 2025-12-01
CN110461359B (zh) 2025-01-21
AU2018240117A1 (en) 2019-09-19
EP3600415B1 (en) 2025-09-17
WO2018175460A1 (en) 2018-09-27
SI3600415T1 (sl) 2026-01-30
US10982000B2 (en) 2021-04-20
US11834508B2 (en) 2023-12-05
EP4678660A3 (en) 2026-04-01
EP3600415A1 (en) 2020-02-05
JP2020511502A (ja) 2020-04-16
RS67504B1 (sr) 2025-12-31
KR20190131096A (ko) 2019-11-25
CN110461359A (zh) 2019-11-15
KR20240014600A (ko) 2024-02-01
RU2019129858A3 (https=) 2022-03-24
LT3600415T (lt) 2025-12-29

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