KR102604877B1 - 감염성 질환의 예방 및/또는 치료와 종양학적 질환의 치료를 위한 약독화된 인플루엔자 벡터 - Google Patents

감염성 질환의 예방 및/또는 치료와 종양학적 질환의 치료를 위한 약독화된 인플루엔자 벡터 Download PDF

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KR102604877B1
KR102604877B1 KR1020177036573A KR20177036573A KR102604877B1 KR 102604877 B1 KR102604877 B1 KR 102604877B1 KR 1020177036573 A KR1020177036573 A KR 1020177036573A KR 20177036573 A KR20177036573 A KR 20177036573A KR 102604877 B1 KR102604877 B1 KR 102604877B1
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influenza
virus
protein
attenuated
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KR20180067464A (ko
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안드레이 유리예비치 이고로프
보리스 페르코
아르템 알렉산드로비치 크로킨
율리아 로마노브나 로마노바
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≪파름엔터프라이지즈 바이오테크≫ 리미티드 라이어빌리티 컴퍼니
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KR1020177036573A 2015-11-06 2016-11-03 감염성 질환의 예방 및/또는 치료와 종양학적 질환의 치료를 위한 약독화된 인플루엔자 벡터 Active KR102604877B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2015147703A RU2628690C2 (ru) 2015-11-06 2015-11-06 Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний
RU2015147703 2015-11-06
PCT/RU2016/050066 WO2017078577A2 (ru) 2015-11-06 2016-11-03 Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний

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KR20180067464A KR20180067464A (ko) 2018-06-20
KR102604877B1 true KR102604877B1 (ko) 2023-11-23

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Families Citing this family (10)

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EP3632433B1 (en) * 2017-05-26 2025-12-24 Vladimir Evgenievich Nebolsin Novel glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases
CN111511397A (zh) * 2017-12-22 2020-08-07 科达金尼克斯有限公司 具有密码子对去优化区域的重组病毒及其用于治疗癌症的用途
CN112040977A (zh) 2018-03-08 2020-12-04 科达金尼克斯有限公司 减毒黄病毒
CN111315407B (zh) 2018-09-11 2023-05-02 上海市公共卫生临床中心 一种广谱抗流感疫苗免疫原及其应用
KR102370100B1 (ko) * 2019-02-15 2022-03-07 아이디바이오 주식회사 이종 인플루엔자 a 바이러스에 대한 면역/치료반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 유전자 전달체 및 치료백신
RU2726106C1 (ru) * 2019-07-18 2020-07-09 федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа им. А.А. Смородинцева" Минздрава России) Рекомбинантный штамм вируса гриппа A/PR8-NS124-TB10.4-2A-HspX и способ специфической профилактики туберкулеза легких с использованием вакцины мукозального применения на его основе
WO2022056398A1 (en) * 2020-09-11 2022-03-17 University Of Georgia Research Foundation, Inc. Compositions and methods of use thereof for prevention and treatment of influenza infections
CN117098553A (zh) * 2020-11-11 2023-11-21 加州理工学院 多价载体和相关疫苗组合物
CN113430178B (zh) * 2021-06-21 2022-10-11 武汉大学 一种表达ii型单纯疱疹病毒蛋白的重组流感病毒株及其制备方法与应用
WO2025041889A1 (ko) * 2023-08-24 2025-02-27 성신여자대학교 연구산학협력단 외래 항원을 발현하는 재조합 인플루엔자 바이러스 벡터 및 이를 포함하는 백신 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007244A2 (en) 2007-06-27 2009-01-15 Avir Green Hills Biotechnology Research Development Trade Ag Replication deficient influenza virus for the expression of heterologous sequences
WO2011014504A1 (en) 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
WO2014041082A1 (en) 2012-09-12 2014-03-20 Medizinische Universität Wien Influenza virus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2400445T3 (es) * 1998-06-12 2013-04-09 Mount Sinai School Of Medicine Virus atenuados con cadena de polaridad negativa con actividad antagonista de interferón alterada para uso como vacunas y productos farmacéuticos
DK1098961T3 (da) * 1998-06-12 2008-05-26 Andrej Y Dr Egorov Gensplejsede svækkede vira, der inducerer interferon
AU2001250352B2 (en) * 2000-03-02 2006-01-12 Polymun Scientific Immunbiologische Forschung Gmbh Recombinant influenza a viruses
US7037707B2 (en) * 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
US7709190B2 (en) * 2005-12-02 2010-05-04 Board Of Regents, The University Of Texas System Influenza A virus vaccines and inhibitors
EP2072058A1 (en) * 2007-12-21 2009-06-24 Avir Green Hills Biotechnology Research Development Trade Ag Modified influenza virus
EP2459585B1 (en) * 2009-07-30 2024-09-04 Icahn School of Medicine at Mount Sinai Influenza viruses and uses thereof
WO2011130652A2 (en) * 2010-04-15 2011-10-20 George Baer Compositions and methods for vaccinating humans and animals against enveloped viruses
EP2576581A4 (en) * 2010-06-06 2015-04-15 Sinai School Medicine RECOMBINANT RNA VIRUSES AND USES THEREOF
EA025152B1 (ru) * 2010-12-02 2016-11-30 Бионор Иммуно Ас Конструкция пептидного каркаса

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007244A2 (en) 2007-06-27 2009-01-15 Avir Green Hills Biotechnology Research Development Trade Ag Replication deficient influenza virus for the expression of heterologous sequences
WO2011014504A1 (en) 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
WO2014041082A1 (en) 2012-09-12 2014-03-20 Medizinische Universität Wien Influenza virus

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