KR102582626B1 - Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체 - Google Patents

Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체 Download PDF

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KR102582626B1
KR102582626B1 KR1020197029735A KR20197029735A KR102582626B1 KR 102582626 B1 KR102582626 B1 KR 102582626B1 KR 1020197029735 A KR1020197029735 A KR 1020197029735A KR 20197029735 A KR20197029735 A KR 20197029735A KR 102582626 B1 KR102582626 B1 KR 102582626B1
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methyl
imidazo
quinoline
chloro
pyran
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KR20190138793A (ko
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마이클 아론 브로드니
토마스 앨런 채피
진산 마이클 첸
요담 워즈워스 코
카렌 진 코프먼
폴 갈라트시스
미셀 르네 간지
크리스토퍼 존 헬랄
재클린 루이스 헨더슨
베서니 린 코모스
라비 지. 쿠룸바일
루이스 앤젤 마티네즈-알시나
마틴 영진 페테르손
매튜 리처드 리즈
콜린 리처드 로즈
안토니아 프리데리케 스테판
파트리크 로베르트 페르회스트
트래비스 티. 웨이저
조셉 스콧 워머스
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020197029735A 2017-03-10 2018-03-06 Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체 Active KR102582626B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762469756P 2017-03-10 2017-03-10
US62/469,756 2017-03-10
US201862629152P 2018-02-12 2018-02-12
US62/629,152 2018-02-12
PCT/IB2018/051439 WO2018163066A1 (en) 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors

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KR20190138793A KR20190138793A (ko) 2019-12-16
KR102582626B1 true KR102582626B1 (ko) 2023-09-22

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US (1) US11312713B2 (https=)
EP (1) EP3592741B1 (https=)
JP (1) JP7219223B2 (https=)
KR (1) KR102582626B1 (https=)
CN (1) CN111051304B (https=)
AU (1) AU2018230236B2 (https=)
BR (1) BR112019018688A2 (https=)
CA (1) CA3056030A1 (https=)
IL (1) IL269214B (https=)
MX (1) MX2019010756A (https=)
SG (2) SG11201908322WA (https=)
TW (1) TWI701246B (https=)
WO (1) WO2018163066A1 (https=)

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BR112022022511A2 (pt) 2020-05-06 2022-12-13 Servier Lab Inibidores macrocíclicos de lrrk2 quinase
EP4236950A4 (en) 2020-10-29 2024-10-23 Merck Sharp & Dohme LLC N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
BR112023017834A2 (pt) 2021-03-18 2023-10-03 Servier Lab Inibidores de lrrk2 cinase macrocíclicos
WO2023220238A1 (en) * 2022-05-12 2023-11-16 Interline Therapeutics, Inc. Lrrk2 inhibitors
CN119403801A (zh) * 2022-05-12 2025-02-07 因特来治疗公司 Lrrk2抑制剂
CN115728413A (zh) * 2022-11-09 2023-03-03 内蒙古帕默康创医疗仪器有限公司 舍曲林血药浓度的定量分析方法
CN116879450A (zh) * 2023-07-25 2023-10-13 江苏汉邦科技股份有限公司 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法
CN118440041B (zh) * 2024-07-02 2024-09-27 苏州凯瑞医药科技有限公司 一种手性4-氨基-3-羟基四氢吡喃的制备方法

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JP2020510046A (ja) 2020-04-02
AU2018230236A1 (en) 2019-10-31
JP7219223B2 (ja) 2023-02-07
CN111051304A (zh) 2020-04-21
EP3592741B1 (en) 2023-02-15
SG11201908322WA (en) 2019-10-30
US20210355117A1 (en) 2021-11-18
BR112019018688A2 (pt) 2020-04-07
NZ757971A (en) 2024-12-20
WO2018163066A1 (en) 2018-09-13
RU2019131727A3 (https=) 2021-04-26
US11312713B2 (en) 2022-04-26
TWI701246B (zh) 2020-08-11
TW201900642A (zh) 2019-01-01
MX2019010756A (es) 2020-01-20
IL269214B (en) 2022-03-01
EP3592741A1 (en) 2020-01-15
AU2018230236B2 (en) 2022-05-19
SG10202110112TA (en) 2021-10-28
RU2019131727A (ru) 2021-04-12
IL269214A (en) 2019-11-28
CA3056030A1 (en) 2018-09-13
CN111051304B (zh) 2022-12-27
KR20190138793A (ko) 2019-12-16

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