IL269214B - Novel imidazo[5,4-c]quinoline derivatives as lrrk2 inhibitors - Google Patents

Novel imidazo[5,4-c]quinoline derivatives as lrrk2 inhibitors

Info

Publication number
IL269214B
IL269214B IL269214A IL26921419A IL269214B IL 269214 B IL269214 B IL 269214B IL 269214 A IL269214 A IL 269214A IL 26921419 A IL26921419 A IL 26921419A IL 269214 B IL269214 B IL 269214B
Authority
IL
Israel
Prior art keywords
quinoline derivatives
lrrk2 inhibitors
novel imidazo
imidazo
novel
Prior art date
Application number
IL269214A
Other languages
English (en)
Hebrew (he)
Other versions
IL269214A (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL269214A publication Critical patent/IL269214A/en
Publication of IL269214B publication Critical patent/IL269214B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL269214A 2017-03-10 2019-09-09 Novel imidazo[5,4-c]quinoline derivatives as lrrk2 inhibitors IL269214B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469756P 2017-03-10 2017-03-10
US201862629152P 2018-02-12 2018-02-12
PCT/IB2018/051439 WO2018163066A1 (en) 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors

Publications (2)

Publication Number Publication Date
IL269214A IL269214A (en) 2019-11-28
IL269214B true IL269214B (en) 2022-03-01

Family

ID=61683855

Family Applications (1)

Application Number Title Priority Date Filing Date
IL269214A IL269214B (en) 2017-03-10 2019-09-09 Novel imidazo[5,4-c]quinoline derivatives as lrrk2 inhibitors

Country Status (13)

Country Link
US (1) US11312713B2 (https=)
EP (1) EP3592741B1 (https=)
JP (1) JP7219223B2 (https=)
KR (1) KR102582626B1 (https=)
CN (1) CN111051304B (https=)
AU (1) AU2018230236B2 (https=)
BR (1) BR112019018688A2 (https=)
CA (1) CA3056030A1 (https=)
IL (1) IL269214B (https=)
MX (1) MX2019010756A (https=)
SG (2) SG11201908322WA (https=)
TW (1) TWI701246B (https=)
WO (1) WO2018163066A1 (https=)

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* Cited by examiner, † Cited by third party
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BR112022022511A2 (pt) 2020-05-06 2022-12-13 Servier Lab Inibidores macrocíclicos de lrrk2 quinase
EP4236950A4 (en) 2020-10-29 2024-10-23 Merck Sharp & Dohme LLC N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
BR112023017834A2 (pt) 2021-03-18 2023-10-03 Servier Lab Inibidores de lrrk2 cinase macrocíclicos
WO2023220238A1 (en) * 2022-05-12 2023-11-16 Interline Therapeutics, Inc. Lrrk2 inhibitors
CN119403801A (zh) * 2022-05-12 2025-02-07 因特来治疗公司 Lrrk2抑制剂
CN115728413A (zh) * 2022-11-09 2023-03-03 内蒙古帕默康创医疗仪器有限公司 舍曲林血药浓度的定量分析方法
CN116879450A (zh) * 2023-07-25 2023-10-13 江苏汉邦科技股份有限公司 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法
CN118440041B (zh) * 2024-07-02 2024-09-27 苏州凯瑞医药科技有限公司 一种手性4-氨基-3-羟基四氢吡喃的制备方法

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Also Published As

Publication number Publication date
JP2020510046A (ja) 2020-04-02
AU2018230236A1 (en) 2019-10-31
JP7219223B2 (ja) 2023-02-07
CN111051304A (zh) 2020-04-21
EP3592741B1 (en) 2023-02-15
SG11201908322WA (en) 2019-10-30
US20210355117A1 (en) 2021-11-18
BR112019018688A2 (pt) 2020-04-07
NZ757971A (en) 2024-12-20
WO2018163066A1 (en) 2018-09-13
RU2019131727A3 (https=) 2021-04-26
US11312713B2 (en) 2022-04-26
TWI701246B (zh) 2020-08-11
TW201900642A (zh) 2019-01-01
MX2019010756A (es) 2020-01-20
EP3592741A1 (en) 2020-01-15
AU2018230236B2 (en) 2022-05-19
SG10202110112TA (en) 2021-10-28
RU2019131727A (ru) 2021-04-12
IL269214A (en) 2019-11-28
CA3056030A1 (en) 2018-09-13
CN111051304B (zh) 2022-12-27
KR102582626B1 (ko) 2023-09-22
KR20190138793A (ko) 2019-12-16

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