SG11201908322WA - Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors - Google Patents
Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitorsInfo
- Publication number
- SG11201908322WA SG11201908322WA SG11201908322WA SG11201908322WA SG 11201908322W A SG11201908322W A SG 11201908322WA SG 11201908322W A SG11201908322W A SG 11201908322WA SG 11201908322W A SG11201908322W A SG 11201908322WA
- Authority
- SG
- Singapore
- Prior art keywords
- connecticut
- massachusetts
- international
- street
- road
- Prior art date
Links
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical class C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 title abstract 3
- 229940124786 LRRK2 inhibitor Drugs 0.000 title abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000007173 Abies balsamea Nutrition 0.000 abstract 1
- 244000283070 Abies balsamea Species 0.000 abstract 1
- 244000046151 Acer negundo Species 0.000 abstract 1
- 235000004422 Acer negundo Nutrition 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 241000167854 Bourreria succulenta Species 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010024229 Leprosy Diseases 0.000 abstract 1
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 abstract 1
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 abstract 1
- 241001508691 Martes zibellina Species 0.000 abstract 1
- 238000006679 Martin dehydration reaction Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 241000220010 Rhode Species 0.000 abstract 1
- 241000220317 Rosa Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 235000019693 cherries Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762469756P | 2017-03-10 | 2017-03-10 | |
| US201862629152P | 2018-02-12 | 2018-02-12 | |
| PCT/IB2018/051439 WO2018163066A1 (en) | 2017-03-10 | 2018-03-06 | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908322WA true SG11201908322WA (en) | 2019-10-30 |
Family
ID=61683855
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908322W SG11201908322WA (en) | 2017-03-10 | 2018-03-06 | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
| SG10202110112T SG10202110112TA (en) | 2017-03-10 | 2018-03-06 | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202110112T SG10202110112TA (en) | 2017-03-10 | 2018-03-06 | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11312713B2 (https=) |
| EP (1) | EP3592741B1 (https=) |
| JP (1) | JP7219223B2 (https=) |
| KR (1) | KR102582626B1 (https=) |
| CN (1) | CN111051304B (https=) |
| AU (1) | AU2018230236B2 (https=) |
| BR (1) | BR112019018688A2 (https=) |
| CA (1) | CA3056030A1 (https=) |
| IL (1) | IL269214B (https=) |
| MX (1) | MX2019010756A (https=) |
| SG (2) | SG11201908322WA (https=) |
| TW (1) | TWI701246B (https=) |
| WO (1) | WO2018163066A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3182162A1 (en) | 2020-05-06 | 2021-11-11 | Les Laboratoires Servier | New macrocyclic lrrk2 kinase inhibitors |
| EP4236950A4 (en) | 2020-10-29 | 2024-10-23 | Merck Sharp & Dohme LLC | N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| TW202304935A (zh) | 2021-03-18 | 2023-02-01 | 法商施維雅藥廠 | 新穎的巨環lrrk2激酶抑制劑 |
| CN119546607A (zh) * | 2022-05-12 | 2025-02-28 | 因特来治疗公司 | Lrrk2抑制剂 |
| EP4522616A4 (en) * | 2022-05-12 | 2026-04-22 | Interline Therapeutics Inc | LRRK2 INHIBITORS |
| CN115728413A (zh) * | 2022-11-09 | 2023-03-03 | 内蒙古帕默康创医疗仪器有限公司 | 舍曲林血药浓度的定量分析方法 |
| CN116879450A (zh) * | 2023-07-25 | 2023-10-13 | 江苏汉邦科技股份有限公司 | 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法 |
| CN118440041B (zh) * | 2024-07-02 | 2024-09-27 | 苏州凯瑞医药科技有限公司 | 一种手性4-氨基-3-羟基四氢吡喃的制备方法 |
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| DE3438830A1 (de) | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
| CA1335996C (en) * | 1988-02-16 | 1995-06-20 | Susumu Takada | 2-substituted carbonylimidazo¬4,5-c|quinolines |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| KR0182801B1 (ko) | 1991-04-16 | 1999-05-01 | 아만 히데아키 | 고체 분산체의 제조방법 |
| US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| JP3265680B2 (ja) | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| EP0683234B2 (en) | 1993-01-25 | 2007-06-06 | Takeda Chemical Industries, Ltd. | Antibody against beta-amyloid or their derivative and use thereof |
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| EP2903989A1 (en) | 2012-10-04 | 2015-08-12 | Pfizer Limited | Pyrrolo[2,3-d]pyrimidine tropomyosin-related kinase inhibitors |
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| ITTO20130694A1 (it) * | 2013-08-14 | 2015-02-15 | Umbra Meccanotecnica | Giunto washpipe per un impianto di perforazione petrolifera |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
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| KR102161364B1 (ko) * | 2015-09-14 | 2020-09-29 | 화이자 인코포레이티드 | LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체 |
| JP2019517580A (ja) | 2016-06-01 | 2019-06-24 | ハロルド・リチャード・ヘルストロムＨａｒｏｌｄ Ｒｉｃｈａｒｄ ＨＥＬＬＳＴＲＯＭ | 副交感神経薬および抗交感神経薬でのドライアイ疾患の処置 |
| EP3592740B1 (en) * | 2017-03-10 | 2022-02-09 | Pfizer Inc. | Cyclic substituted imidazo[4,5-c]quinoline derivatives |
-
2018
- 2018-03-06 WO PCT/IB2018/051439 patent/WO2018163066A1/en not_active Ceased
- 2018-03-06 CN CN201880029989.5A patent/CN111051304B/zh active Active
- 2018-03-06 EP EP18711703.1A patent/EP3592741B1/en active Active
- 2018-03-06 KR KR1020197029735A patent/KR102582626B1/ko active Active
- 2018-03-06 US US16/492,558 patent/US11312713B2/en active Active
- 2018-03-06 AU AU2018230236A patent/AU2018230236B2/en active Active
- 2018-03-06 SG SG11201908322W patent/SG11201908322WA/en unknown
- 2018-03-06 CA CA3056030A patent/CA3056030A1/en active Pending
- 2018-03-06 JP JP2019549462A patent/JP7219223B2/ja active Active
- 2018-03-06 MX MX2019010756A patent/MX2019010756A/es unknown
- 2018-03-06 SG SG10202110112T patent/SG10202110112TA/en unknown
- 2018-03-06 BR BR112019018688A patent/BR112019018688A2/pt not_active Application Discontinuation
- 2018-03-07 TW TW107107734A patent/TWI701246B/zh active
-
2019
- 2019-09-09 IL IL269214A patent/IL269214B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20210355117A1 (en) | 2021-11-18 |
| EP3592741A1 (en) | 2020-01-15 |
| TW201900642A (zh) | 2019-01-01 |
| CN111051304B (zh) | 2022-12-27 |
| NZ757971A (en) | 2024-12-20 |
| AU2018230236B2 (en) | 2022-05-19 |
| KR102582626B1 (ko) | 2023-09-22 |
| IL269214A (en) | 2019-11-28 |
| CA3056030A1 (en) | 2018-09-13 |
| KR20190138793A (ko) | 2019-12-16 |
| BR112019018688A2 (pt) | 2020-04-07 |
| IL269214B (en) | 2022-03-01 |
| CN111051304A (zh) | 2020-04-21 |
| US11312713B2 (en) | 2022-04-26 |
| TWI701246B (zh) | 2020-08-11 |
| EP3592741B1 (en) | 2023-02-15 |
| WO2018163066A1 (en) | 2018-09-13 |
| MX2019010756A (es) | 2020-01-20 |
| AU2018230236A1 (en) | 2019-10-31 |
| RU2019131727A3 (https=) | 2021-04-26 |
| JP7219223B2 (ja) | 2023-02-07 |
| SG10202110112TA (en) | 2021-10-28 |
| JP2020510046A (ja) | 2020-04-02 |
| RU2019131727A (ru) | 2021-04-12 |
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