KR102582021B1 - Gpr139의 모듈레이터로서의 4-옥소-3,4-디히드로-1,2,3-벤조트리아진 - Google Patents

Gpr139의 모듈레이터로서의 4-옥소-3,4-디히드로-1,2,3-벤조트리아진 Download PDF

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KR102582021B1
KR102582021B1 KR1020177016973A KR20177016973A KR102582021B1 KR 102582021 B1 KR102582021 B1 KR 102582021B1 KR 1020177016973 A KR1020177016973 A KR 1020177016973A KR 20177016973 A KR20177016973 A KR 20177016973A KR 102582021 B1 KR102582021 B1 KR 102582021B1
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oxobenzo
acetamide
triazin
ethyl
methoxy
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스티븐 히치콕
베티 램
홀저 모넨쉐인
홀리 리차드
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다케다 야쿠힌 고교 가부시키가이샤
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020177016973A 2014-11-20 2015-11-19 Gpr139의 모듈레이터로서의 4-옥소-3,4-디히드로-1,2,3-벤조트리아진 Active KR102582021B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462082539P 2014-11-20 2014-11-20
US62/082,539 2014-11-20
US201562184729P 2015-06-25 2015-06-25
US62/184,729 2015-06-25
PCT/US2015/061607 WO2016081736A1 (en) 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139

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Publication Number Publication Date
KR20170084324A KR20170084324A (ko) 2017-07-19
KR102582021B1 true KR102582021B1 (ko) 2023-09-22

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
US12042496B2 (en) 2018-10-16 2024-07-23 The University Of Florida Research Foundation, Incorporated Methods related to opioid therapeutics
WO2020097609A1 (en) * 2018-11-09 2020-05-14 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
CR20220160A (es) * 2019-09-16 2022-06-16 Takeda Pharmaceuticals Co Derivados de piridazin-3(2h)-ona fusionados con azol
WO2021127459A1 (en) * 2019-12-20 2021-06-24 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
JP7697974B2 (ja) * 2020-05-08 2025-06-24 武田薬品工業株式会社 Ｇｐｒ１３９アゴニストの置換ベンゾトリアジノン代謝物
JP2023541485A (ja) * 2020-09-21 2023-10-02 武田薬品工業株式会社 統合失調症のための処置
US11760788B2 (en) 2021-03-02 2023-09-19 Pathways Neuro Pharma, Inc. Neuroreceptor compositions and methods of use
CN116693545A (zh) * 2022-03-01 2023-09-05 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
WO2023165263A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用
CN117986183A (zh) * 2022-10-28 2024-05-07 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂、其制备方法及其应用
WO2024102802A1 (en) * 2022-11-11 2024-05-16 Takeda Pharmaceutical Company Limited Zelatriazin for the treatment of depression
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
WO2025162441A1 (zh) * 2024-02-02 2025-08-07 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794726A (en) * 1972-08-21 1974-02-26 Uniroyal Inc Inhibiting aggressive behavior with 1,2,3-benzotriazin-(3h)-one
WO1987004928A1 (fr) 1986-02-24 1987-08-27 Mitsui Petrochemical Industries, Ltd. Agents therapeutiques de la neuropathie
ATE108791T1 (de) 1987-11-04 1994-08-15 Beecham Group Plc Neue 4-oxobenzotriazine und 4-oxochinazoline.
PE20050630A1 (es) 2003-06-09 2005-09-22 Boehringer Ingelheim Int Compuestos heterociclicos como inhibidores del papiloma virus
CA2533824A1 (en) 2003-07-31 2005-02-10 Irm, Llc Bicyclic compounds and compositions as pdf inhibitors
FR2875805B1 (fr) 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
UY30048A1 (es) 2005-12-23 2007-07-31 Astrazeneca Ab Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
MX2009010218A (es) * 2007-03-23 2009-10-19 Hoffmann La Roche Derivados de aza-piridopirimidinona.
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011138265A2 (en) 2010-05-03 2011-11-10 Evotec Ag Indole and indazole derivatives as orexin receptor antagonists
JP2016515138A (ja) * 2013-03-14 2016-05-26 ヤンセン ファーマシューティカ エヌ．ベー． Ｇｐｒ１３９の生理的リガンド
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACS Medical Chemistry Letters, (2011) Vol. 2, pp. 303-306

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JP6918088B2 (ja) 2021-08-11
TW201625566A (zh) 2016-07-16
JP2020063285A (ja) 2020-04-23
ES2734735T3 (es) 2019-12-11
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BR112017010311A2 (pt) 2017-12-26
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PT3221298T (pt) 2019-06-28
SI3221298T1 (sl) 2019-10-30
SG11201704002UA (en) 2017-06-29
CN112062730A (zh) 2020-12-11
US20190070187A1 (en) 2019-03-07
CA2968242A1 (en) 2016-05-26
US11173161B2 (en) 2021-11-16
KR20170084324A (ko) 2017-07-19
US20170095480A1 (en) 2017-04-06
TWI684590B (zh) 2020-02-11
HUE057451T2 (hu) 2022-05-28
JP2017535559A (ja) 2017-11-30
CR20170275A (es) 2017-10-30
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PE20170899A1 (es) 2017-07-12
PL3536324T3 (pl) 2022-02-07
HUE044145T2 (hu) 2019-09-30
CO2017005959A2 (es) 2017-10-20
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ECSP17038999A (es) 2017-10-31
MX378158B (es) 2025-03-10
DK3221298T3 (da) 2019-06-24
GEP20196961B (en) 2019-03-25
PT3536324T (pt) 2021-11-10
IL252311B (en) 2020-07-30
EA033728B1 (ru) 2019-11-20
SMT202200142T1 (it) 2022-05-12
NZ732208A (en) 2023-02-24
US20160145218A1 (en) 2016-05-26
CN107108531A (zh) 2017-08-29
US20200129518A1 (en) 2020-04-30
AU2015349866B2 (en) 2020-12-03
EP3221298B1 (en) 2019-04-03
CN107108531B (zh) 2020-10-20
ES2897545T3 (es) 2022-03-01
UA120375C2 (uk) 2019-11-25
EP3536324B1 (en) 2021-10-06
JP6637501B2 (ja) 2020-01-29
CY1124929T1 (el) 2023-01-05
US9556130B2 (en) 2017-01-31
EA201791096A1 (ru) 2017-11-30
US9770450B2 (en) 2017-09-26
DK3536324T3 (da) 2021-10-25
SI3536324T1 (sl) 2021-12-31
PL3221298T3 (pl) 2019-10-31
CL2017001292A1 (es) 2018-02-16
IL252311A0 (en) 2017-07-31
MA40993A (fr) 2017-09-27
MA40993B1 (fr) 2019-07-31
HRP20212009T1 (hr) 2022-04-01
MX2017006448A (es) 2017-09-12
DOP2017000120A (es) 2017-06-15
MY187423A (en) 2021-09-22
CY1122613T1 (el) 2021-05-05
MD3221298T2 (ro) 2019-10-31
LT3221298T (lt) 2019-08-12
WO2016081736A1 (en) 2016-05-26
RS59078B1 (sr) 2019-09-30
US10159677B2 (en) 2018-12-25
EP3536324A1 (en) 2019-09-11
UY36406A (es) 2016-06-30
US20170348319A1 (en) 2017-12-07
SMT201900355T1 (it) 2019-07-11

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