KR102581296B1 - 막 지질 코팅된 나노입자 및 사용 방법 - Google Patents

막 지질 코팅된 나노입자 및 사용 방법 Download PDF

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KR102581296B1
KR102581296B1 KR1020197034265A KR20197034265A KR102581296B1 KR 102581296 B1 KR102581296 B1 KR 102581296B1 KR 1020197034265 A KR1020197034265 A KR 1020197034265A KR 20197034265 A KR20197034265 A KR 20197034265A KR 102581296 B1 KR102581296 B1 KR 102581296B1
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virus
nanoparticles
membrane
cell
cells
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KR20190137906A (ko
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에디 요콘 청
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코스타 쎄라퓨틱스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020197034265A 2017-04-21 2018-04-21 막 지질 코팅된 나노입자 및 사용 방법 Active KR102581296B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762488685P 2017-04-21 2017-04-21
US62/488,685 2017-04-21
PCT/US2018/028752 WO2018195526A1 (en) 2017-04-21 2018-04-21 Membrane lipid coated nanoparticles and method of use

Publications (2)

Publication Number Publication Date
KR20190137906A KR20190137906A (ko) 2019-12-11
KR102581296B1 true KR102581296B1 (ko) 2023-09-22

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Country Status (6)

Country Link
US (1) US11413252B2 (https=)
EP (1) EP3612169A4 (https=)
JP (1) JP7329839B2 (https=)
KR (1) KR102581296B1 (https=)
CN (2) CN110621306A (https=)
WO (1) WO2018195526A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018316166A1 (en) 2017-08-07 2020-02-06 The Regents Of The University Of California Platform for generating safe cell therapeutics
AU2020315645A1 (en) 2019-07-16 2022-02-17 Coastar Therapeutics Inc. Process of making membrane lipid coated nanoparticles
CN110638784A (zh) * 2019-09-27 2020-01-03 兆科（广州）肿瘤药物有限公司 一种载有溶瘤病毒的载药微球及其制备方法
WO2021150460A1 (en) * 2020-01-20 2021-07-29 Arytha Biosciences Llc Devices containing cellular membrane and uses thereof
WO2023113550A1 (ko) * 2021-12-16 2023-06-22 주식회사 포투가바이오 수지상세포 모방 기능성 나노구조체 및 이의 제조방법
CN117379389B (zh) * 2022-07-12 2026-03-06 四川大学 血小板-溶瘤病毒复合物、其制备方法及其应用
CN115252582B (zh) * 2022-08-19 2024-01-02 复旦大学 红细胞膜杂合pH脂质体包被溶瘤病毒制剂的制备及应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005525992A (ja) 2001-06-25 2005-09-02 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム 生物学的物質を充填した小胞の調製法およびそれらの様々な使用
WO2006090816A1 (ja) 2005-02-25 2006-08-31 Mie University リポソームワクチンの作製法
US20100203024A1 (en) 2006-05-30 2010-08-12 Terman David S Sickled Erythrocytes, Nucleated Precursors & Erythroleukemia Cells for Targeted Delivery of Oncolytic Viruses, Anti-tumor Proteins, Plasmids, Toxins, Hemolysins & Chemotherapy
WO2013052167A2 (en) * 2011-06-02 2013-04-11 The Regents Of The University Of California Membrane encapsulated nanoparticles and method of use
WO2014172685A1 (en) * 2013-04-18 2014-10-23 The Regents Of The University Of California Nanoscale coatings for encapsulation of biological entities
US20150284691A1 (en) 2012-10-29 2015-10-08 The Regents Of The University Of California Composition of viral vectors in lecithin liposomes, preparation method and treatment methods
US20160317591A1 (en) 2013-03-13 2016-11-03 Karen S. Aboody Tropic cell based virotherapy for the treatment of cancer
WO2016192451A1 (zh) 2015-05-29 2016-12-08 湖北盛齐安生物科技有限公司 一种溶瘤病毒制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69517683T2 (de) * 1994-03-15 2001-06-07 Medical College Of Pennsylvania And Hahnemann University, Philadelphia Alpha-galactosyl-epitope enthaltende zusammensetzungen und verfahren für impfstoffe
US20140350087A9 (en) * 2012-03-22 2014-11-27 Halozyme, Inc. Oncovector Nucleic Acid Molecules and Methods of Use
US20140335115A1 (en) * 2013-05-07 2014-11-13 Oregon Health & Science University Suppressors of mature t cells
EP3169309B1 (en) * 2014-07-16 2023-05-10 Novartis AG Method of encapsulating a nucleic acid in a lipid nanoparticle host
US11224577B2 (en) * 2015-06-19 2022-01-18 The Regents Of The University Of California Treating infection by a platelet-targeting microbe using nanoparticles

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005525992A (ja) 2001-06-25 2005-09-02 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム 生物学的物質を充填した小胞の調製法およびそれらの様々な使用
WO2006090816A1 (ja) 2005-02-25 2006-08-31 Mie University リポソームワクチンの作製法
US20100203024A1 (en) 2006-05-30 2010-08-12 Terman David S Sickled Erythrocytes, Nucleated Precursors & Erythroleukemia Cells for Targeted Delivery of Oncolytic Viruses, Anti-tumor Proteins, Plasmids, Toxins, Hemolysins & Chemotherapy
WO2013052167A2 (en) * 2011-06-02 2013-04-11 The Regents Of The University Of California Membrane encapsulated nanoparticles and method of use
US20150284691A1 (en) 2012-10-29 2015-10-08 The Regents Of The University Of California Composition of viral vectors in lecithin liposomes, preparation method and treatment methods
US20160317591A1 (en) 2013-03-13 2016-11-03 Karen S. Aboody Tropic cell based virotherapy for the treatment of cancer
WO2014172685A1 (en) * 2013-04-18 2014-10-23 The Regents Of The University Of California Nanoscale coatings for encapsulation of biological entities
US20160067191A1 (en) 2013-04-18 2016-03-10 The Regents Of The University Of California Nanoscale coatings for encapsulation of biological entities
WO2016192451A1 (zh) 2015-05-29 2016-12-08 湖北盛齐安生物科技有限公司 一种溶瘤病毒制剂及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of the National Cancer Institute 106(6):1-9(2014.05.16.)
Molecular Cancer Therapeutics 5(3):755-766(2006.03.01.)

Also Published As

Publication number Publication date
CN110621306A (zh) 2019-12-27
EP3612169A4 (en) 2020-09-09
JP2020519241A (ja) 2020-07-02
KR20190137906A (ko) 2019-12-11
US20200060979A1 (en) 2020-02-27
EP3612169A1 (en) 2020-02-26
WO2018195526A1 (en) 2018-10-25
JP7329839B2 (ja) 2023-08-21
US11413252B2 (en) 2022-08-16
CN121154578A (zh) 2025-12-19

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