KR102548341B1 - 개선된 치료 지수를 갖는 암포테리신 b 유도체 - Google Patents

개선된 치료 지수를 갖는 암포테리신 b 유도체 Download PDF

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KR102548341B1
KR102548341B1 KR1020217035284A KR20217035284A KR102548341B1 KR 102548341 B1 KR102548341 B1 KR 102548341B1 KR 1020217035284 A KR1020217035284 A KR 1020217035284A KR 20217035284 A KR20217035284 A KR 20217035284A KR 102548341 B1 KR102548341 B1 KR 102548341B1
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synthesis
compound
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KR20210132248A (ko
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마틴 디. 버크
스티븐 데이비스
브리스 이. 우노
저스틴 스트루블
이안 데일리
케이틀린 씨. 그레이
데이비드 엠. 냅
푸린 왕
나가르주나 팔리암
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더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020217035284A 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체 Active KR102548341B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
KR1020167011985A KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

Related Parent Applications (1)

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KR1020167011985A Division KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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KR20210132248A KR20210132248A (ko) 2021-11-03
KR102548341B1 true KR102548341B1 (ko) 2023-06-26

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KR1020217035284A Active KR102548341B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체
KR1020167011985A Active KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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US (4) US10323057B2 (https=)
EP (1) EP3055030B1 (https=)
JP (2) JP6600303B2 (https=)
KR (2) KR102548341B1 (https=)
CN (2) CN110407898B (https=)
AU (2) AU2014332214B2 (https=)
CA (1) CA2925904C (https=)
DK (1) DK3055030T3 (https=)
ES (1) ES2682328T3 (https=)
SG (1) SG11201602570WA (https=)
WO (1) WO2015054148A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
MA39568A1 (fr) 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016112260A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
EP3439668B1 (en) 2016-04-08 2024-06-19 The Board of Trustees of the University of Illinois Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
CA3111565A1 (en) * 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
KR20220058547A (ko) * 2019-08-08 2022-05-09 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
IL315719A (en) 2022-03-21 2024-11-01 Univ Illinois Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals
WO2024010968A2 (en) * 2022-07-08 2024-01-11 The Board Of Trustees Of The University Of Illinois Transfer of c2'-epimerized sugars to the amphotericin b aglycone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

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EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
US8053418B2 (en) 2005-01-24 2011-11-08 Microbial Chemistry Research Foundation Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative
KR20070116254A (ko) 2005-03-23 2007-12-07 콘세호수페리오르데인베스티가시오네스시엔티피카스 폴리엔 항생물질, 이 항생물질을 함유하는 조성물, 이것을얻는데 사용되는 방법 및 미생물, 그리고 그 적용
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
JP7240811B2 (ja) 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体

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Publication number Priority date Publication date Assignee Title
US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

Non-Patent Citations (4)

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A.N.Tevyashova et al., Antimicrobial Agents and Chemotherapy, 2013, Vol.57, No.8, 3815-3822쪽
B. Byrne et al., 'Biosynthesis of Deoxyamphotericins and Deoxyamphoteronolides by Engineered Strains of Streptomyces nodosus', Chemistry & Biology, 2003, Vol. 10, 1215-1224쪽*
D.M.GEISER, "Antifungal design: The toxicity-resistance yin-yang", NATURE CHEMICAL BIOLOGY, 2015, vol.11, no.7, pp.453-454
S.A.DAVIS et al., "C3-OH of Amphotericin B Plays an Important Role in Ion Conductance", J. of the American Chem. Soc., 2015, vol.137, no.48, pp.15102-15104

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JP7469862B2 (ja) 2024-04-17
KR20210132248A (ko) 2021-11-03
CN110407898B (zh) 2023-12-01
CA2925904A1 (en) 2015-04-16
EP3055030A4 (en) 2017-03-15
US11117920B2 (en) 2021-09-14
US11970512B2 (en) 2024-04-30
AU2019279928B2 (en) 2020-07-23
US11028114B2 (en) 2021-06-08
CN110407898A (zh) 2019-11-05
JP2016531894A (ja) 2016-10-13
AU2014332214B2 (en) 2019-10-03
US20220056066A1 (en) 2022-02-24
ES2682328T3 (es) 2018-09-20
CN105848721A (zh) 2016-08-10
CN105848721B (zh) 2019-08-23
NZ757647A (en) 2021-06-25
US20190345187A1 (en) 2019-11-14
US20200002368A1 (en) 2020-01-02
US10323057B2 (en) 2019-06-18
WO2015054148A1 (en) 2015-04-16
DK3055030T3 (en) 2018-08-13
AU2019279928A1 (en) 2020-01-16
JP6600303B2 (ja) 2019-10-30
EP3055030A1 (en) 2016-08-17
EP3055030B1 (en) 2018-05-02
JP2020019804A (ja) 2020-02-06
SG11201602570WA (en) 2016-04-28
US20160215012A1 (en) 2016-07-28
KR20160068861A (ko) 2016-06-15
KR102321482B1 (ko) 2021-11-02
AU2014332214A1 (en) 2016-05-19
CA2925904C (en) 2021-11-23
NZ719529A (en) 2021-06-25

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