CA2925904C - Amphotericin b derivatives with improved therapeutic index - Google Patents

Amphotericin b derivatives with improved therapeutic index Download PDF

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Publication number
CA2925904C
CA2925904C CA2925904A CA2925904A CA2925904C CA 2925904 C CA2925904 C CA 2925904C CA 2925904 A CA2925904 A CA 2925904A CA 2925904 A CA2925904 A CA 2925904A CA 2925904 C CA2925904 C CA 2925904C
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CA
Canada
Prior art keywords
amb
compound
synthesis
derivatives
scheme
Prior art date
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Application number
CA2925904A
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English (en)
French (fr)
Other versions
CA2925904A1 (en
Inventor
Martin D. Burke
Stephen Davis
Brice E. Uno
Justin Struble
Ian DAILEY
Kaitlyn C. Gray
David M. Knapp
Pulin Wang
Nagarjuna PALYAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
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University of Illinois System
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Publication date
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Publication of CA2925904A1 publication Critical patent/CA2925904A1/en
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Publication of CA2925904C publication Critical patent/CA2925904C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2925904A 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index Active CA2925904C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

Publications (2)

Publication Number Publication Date
CA2925904A1 CA2925904A1 (en) 2015-04-16
CA2925904C true CA2925904C (en) 2021-11-23

Family

ID=52813555

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2925904A Active CA2925904C (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

Country Status (11)

Country Link
US (4) US10323057B2 (https=)
EP (1) EP3055030B1 (https=)
JP (2) JP6600303B2 (https=)
KR (2) KR102548341B1 (https=)
CN (2) CN110407898B (https=)
AU (2) AU2014332214B2 (https=)
CA (1) CA2925904C (https=)
DK (1) DK3055030T3 (https=)
ES (1) ES2682328T3 (https=)
SG (1) SG11201602570WA (https=)
WO (1) WO2015054148A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
MA39568A1 (fr) 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016112260A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
EP3439668B1 (en) 2016-04-08 2024-06-19 The Board of Trustees of the University of Illinois Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
CA3111565A1 (en) * 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
KR20220058547A (ko) * 2019-08-08 2022-05-09 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
IL315719A (en) 2022-03-21 2024-11-01 Univ Illinois Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals
WO2024010968A2 (en) * 2022-07-08 2024-01-11 The Board Of Trustees Of The University Of Illinois Transfer of c2'-epimerized sugars to the amphotericin b aglycone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
US8053418B2 (en) 2005-01-24 2011-11-08 Microbial Chemistry Research Foundation Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative
KR20070116254A (ko) 2005-03-23 2007-12-07 콘세호수페리오르데인베스티가시오네스시엔티피카스 폴리엔 항생물질, 이 항생물질을 함유하는 조성물, 이것을얻는데 사용되는 방법 및 미생물, 그리고 그 적용
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives
US20070238746A1 (en) * 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
JP7240811B2 (ja) 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体

Also Published As

Publication number Publication date
JP7469862B2 (ja) 2024-04-17
KR20210132248A (ko) 2021-11-03
CN110407898B (zh) 2023-12-01
CA2925904A1 (en) 2015-04-16
EP3055030A4 (en) 2017-03-15
KR102548341B1 (ko) 2023-06-26
US11117920B2 (en) 2021-09-14
US11970512B2 (en) 2024-04-30
AU2019279928B2 (en) 2020-07-23
US11028114B2 (en) 2021-06-08
CN110407898A (zh) 2019-11-05
JP2016531894A (ja) 2016-10-13
AU2014332214B2 (en) 2019-10-03
US20220056066A1 (en) 2022-02-24
ES2682328T3 (es) 2018-09-20
CN105848721A (zh) 2016-08-10
CN105848721B (zh) 2019-08-23
NZ757647A (en) 2021-06-25
US20190345187A1 (en) 2019-11-14
US20200002368A1 (en) 2020-01-02
US10323057B2 (en) 2019-06-18
WO2015054148A1 (en) 2015-04-16
DK3055030T3 (en) 2018-08-13
AU2019279928A1 (en) 2020-01-16
JP6600303B2 (ja) 2019-10-30
EP3055030A1 (en) 2016-08-17
EP3055030B1 (en) 2018-05-02
JP2020019804A (ja) 2020-02-06
SG11201602570WA (en) 2016-04-28
US20160215012A1 (en) 2016-07-28
KR20160068861A (ko) 2016-06-15
KR102321482B1 (ko) 2021-11-02
AU2014332214A1 (en) 2016-05-19
NZ719529A (en) 2021-06-25

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