CN110407898B - 具有提高的治疗指数的两性霉素b衍生物 - Google Patents
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- CN110407898B CN110407898B CN201910693627.2A CN201910693627A CN110407898B CN 110407898 B CN110407898 B CN 110407898B CN 201910693627 A CN201910693627 A CN 201910693627A CN 110407898 B CN110407898 B CN 110407898B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
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| CN201910693627.2A CN110407898B (zh) | 2013-10-07 | 2014-10-06 | 具有提高的治疗指数的两性霉素b衍生物 |
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| US62/045956 | 2014-09-04 | ||
| CN201910693627.2A CN110407898B (zh) | 2013-10-07 | 2014-10-06 | 具有提高的治疗指数的两性霉素b衍生物 |
| CN201480065533.6A CN105848721B (zh) | 2013-10-07 | 2014-10-06 | 具有提高的治疗指数的两性霉素b衍生物 |
| PCT/US2014/059334 WO2015054148A1 (en) | 2013-10-07 | 2014-10-06 | Amphotericin b derivatives with improved therapeutic index |
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| CN110407898A CN110407898A (zh) | 2019-11-05 |
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| CN201480065533.6A Active CN105848721B (zh) | 2013-10-07 | 2014-10-06 | 具有提高的治疗指数的两性霉素b衍生物 |
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| EP (1) | EP3055030B1 (https=) |
| JP (2) | JP6600303B2 (https=) |
| KR (2) | KR102548341B1 (https=) |
| CN (2) | CN110407898B (https=) |
| AU (2) | AU2014332214B2 (https=) |
| CA (1) | CA2925904C (https=) |
| DK (1) | DK3055030T3 (https=) |
| ES (1) | ES2682328T3 (https=) |
| SG (1) | SG11201602570WA (https=) |
| WO (1) | WO2015054148A1 (https=) |
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| KR102548341B1 (ko) | 2013-10-07 | 2023-06-26 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| MA39568A1 (fr) | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016112260A1 (en) | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin b |
| JP7240811B2 (ja) * | 2015-04-15 | 2023-03-16 | スファンガ セラピューティクス インコーポレイテッド | アムホテリシンｂの誘導体 |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| EP3439668B1 (en) | 2016-04-08 | 2024-06-19 | The Board of Trustees of the University of Illinois | Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| CA3111565A1 (en) * | 2018-09-07 | 2020-03-12 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| KR20220058547A (ko) * | 2019-08-08 | 2022-05-09 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체 |
| CN111909226A (zh) * | 2020-08-11 | 2020-11-10 | 深圳市儿童医院 | 一种葡萄糖酸修饰的两性霉素b衍生物及其用途 |
| IL315719A (en) | 2022-03-21 | 2024-11-01 | Univ Illinois | Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals |
| WO2024010968A2 (en) * | 2022-07-08 | 2024-01-11 | The Board Of Trustees Of The University Of Illinois | Transfer of c2'-epimerized sugars to the amphotericin b aglycone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204330A (en) * | 1989-12-08 | 1993-04-20 | Beecham Group P.L.C. | Antifungal compounds |
| WO1993016090A1 (en) * | 1992-02-12 | 1993-08-19 | Smithkline Beecham Plc | Amphotericin b derivative |
| WO2009004322A2 (en) * | 2007-07-03 | 2009-01-08 | Biosergen As | Derivatives of nystatin and their use as antifungal agents |
Family Cites Families (9)
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| US8053418B2 (en) | 2005-01-24 | 2011-11-08 | Microbial Chemistry Research Foundation | Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative |
| KR20070116254A (ko) | 2005-03-23 | 2007-12-07 | 콘세호수페리오르데인베스티가시오네스시엔티피카스 | 폴리엔 항생물질, 이 항생물질을 함유하는 조성물, 이것을얻는데 사용되는 방법 및 미생물, 그리고 그 적용 |
| WO2007096137A1 (en) * | 2006-02-23 | 2007-08-30 | Eth Zurich | Amphotericin derivatives |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| DE102006060008A1 (de) | 2006-12-19 | 2008-06-26 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Lampe mit verbesserter Quetschungsgeometrie |
| MX365184B (es) | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| KR102548341B1 (ko) | 2013-10-07 | 2023-06-26 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| JP7240811B2 (ja) | 2015-04-15 | 2023-03-16 | スファンガ セラピューティクス インコーポレイテッド | アムホテリシンｂの誘導体 |
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